Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands
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Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands
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Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands
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Introduction Testosterone therapy (TTh) is prescribed to hypogonadal men to correct testosterone levels and alleviate symptoms that result from its deficiency. Benefits include improved sexual function and quality of life ( 1 ), improvements
Tanaka Medical Clinic, Yoichi, Japan
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Institute for Clinical Research, NHO Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan
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Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo, Japan
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, since the FABP4 gene is a target of PPARγ. Patients with T1DM were defined as those diagnosed with T1DM by their attending physicians and those receiving at least insulin therapy. Patients with T2DM were defined as those having DM except for T1DM and DM
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be in CKD stages 1 and 2. The results of analysis of baseline characteristics by sex are summarized in Table 2 . There was a clear difference between men and women for smoking status: of the 2545 men, 1933 (76.0%) were smokers, while only 276 of 2343
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.441 BMI (kg/m 2 ) 0.998 (0.930–1.071) 0.963 FT4 (pmol/L) 1.004 (0.999–1.010) 0.141 24 h RAIU (%) 1.023 (1.007–1.039) 0.004 FT4, free thyroxine; M/F, men/female; RAIU, radioactive iodine uptake rate
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expression has been identified in the rat ( 11 ), mouse ( 14 ), and human prostate biopsies ( www.proteinatlas.org ). An inverse correlation between Dio1 or Dio2 and Dio3 gene expression was observed in the normal and cancerous prostate of euthyroid mice
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SRY and DMRT1 genes. Direct sequencing The search for DNA point mutations in SRY, DHH, NR5A1, SRD5A2, AR, AMH, CYP21A2, CYP11B1, RSPO1 , and WNT4 genes was carried out by PCR followed by direct sequencing. SRD5A2, CYP21A2 , AMH , and CYP11B1
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to men (45.5 years ( n = 10), ( P = 0.62)) or for the number of individuals with an SDHX variant (30 female, 29 male, P = 0.34) ( Table 1 ). Most patients were diagnosed with variants in the SDHB gene (51/59). Only two, four, and two
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. 2013 48 SI-NETs Exome sequencing 0.1 SNVs* per 10 6 nucleotides No recurrent mutations in cancer genes. 197 protein-altering SNVs affected multiple cancer genes, including FGFR2 , MEN1 , HOOK3 , EZH2 , MLF1 , CARD11 , VHL , NONO and
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men ( 5 ). The incidence of tumours within the brain and CNS has increased gradually during the last 30 years for both genders, but especially during the last 10–15 years ( Fig. 1 ). The most common type of primary brain tumour among adults is
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expression of Gli1 and its target genes in MEN1-depeleted cells ( 149 ). Thus, non-functional menin engenders Gas1 expression and thereby foments pro-proliferative and oncogenic Hh signalling, suggesting Menin/PRMT5/hedgehog signalling as a potential target