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, n (%) 317 (44.7) Mean age, years ( s.d. ) ( n = 683) 47.0 (14.0) Mean IGF-I SDS ( s.d. ) ( n = 554) −1.16 (1.43) Mean BMI, kg/m 2 ( s.d. ) ( n = 608) 28.8 (6.2) Number of pituitary deficiencies, n
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genetic as well as biochemical approaches have independently confirmed that mTOR/S6K plays a novel and essential role in the regulation of cell autonomous insulin/IGF-I sensitivity through affecting IRS-1 function ( 35 ), we also analyzed the expression of
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-onset hypopituitarism, who have severe GHD and low insulin-like growth factor-I (IGF-I) levels, are likely to have permanent GHD. Testing should be undertaken after at least one month after discontinuation of GH therapy and patients with discordant tests or those at
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December 2022 at the Beijing Tiantan Hospital. The inclusion criteria were: (i) the defined diagnosis based on human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in serum and cerebrospinal fluid (CSF), histological features and patterns, and the
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and or radiotherapy at our institution. After treatment, patients who had suppressible GH OGTT (<1 ng/ml) were subjected to insulin-induced hypoglycemia (IIH). GHD was defined as peak GH level ≤3 ng/ml during IIH and insulin-like growth factor 1 (IGF1
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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TSHR induces cross-talk with insulin-like growth factor 1 receptor (IGF1R) ( 10 ), which results in elevated levels of hyaluronic acid, leading to the disruption of the extraocular muscles ( 11 ). T cells bind to CD40 on orbital fibroblasts and induce
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Endoscopic Skull Base Unit, Department of Neurosurgery, Hospital Universitario HM Puerta del Sur, Madrid, Spain
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were: (i) Confirmed acromegaly diagnosis (GH levels >1 ng/mL after oral glucose tolerance test (OGTT)) and fasting plasma IGF1 levels above reference ranges for age and sex ( 1 ), (ii) operated by the senior author and (iii) with a tumor size ≥10 mm
Universitat Oberta Catalunya (UOC), Barcelona, Spain
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Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain
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Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
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cause (43.7%). Male/female ratio stands at 3.9/1, tetraplegia (cervical lesions) accounts for 38.5% of the cases and complete injuries affect 56.7% of the patients ( 6 ). As known, GH mediates its action mainly on the liver acting through IGF1
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Koppeschaar HP. Growth hormone, insulin-like growth factor I and cognitive function in adults . Growth Hormone and IGF Research 2000 10 ( Supplement B ) S69 – S73 . ( https://doi.org/10.1016/S1096-6374(00)80013-1 ) 10.1016/S1096-6374(00)80013-1) 2
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Moriya H Nakabayashi I Nishiyama J Fukuda T . Angiotensin II and IGF-I may interact to regulate tubulointerstitial cell kinetics and phenotypic changes in hypertensive rats . Hypertension Research 2002 25 257 – 269 . ( https