Riccardo Pofi
Riccardo Pofi
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK
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Ilaria Bonaventura
Ilaria Bonaventura
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy
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Joanne Duffy
Joanne Duffy
Department of Clinical Chemistry and Immunology, Heartlands Hospital, Birmingham, UK
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Zoe Maunsell
Zoe Maunsell
Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
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Brian Shine
Brian Shine
Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
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Andrea M Isidori
Andrea M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy
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Jeremy W Tomlinson
Jeremy W Tomlinson
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK
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( 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ). In contrast, there has been comparatively little attention on MC replacement ( 12 , 22 , 23 ). Currently, the Endocrine Society’s guidelines recommend monitoring MC replacement through clinical
Clara Lundetoft Clausen
Clara Lundetoft Clausen
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Trine Holm Johannsen
Trine Holm Johannsen
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Niels Erik Skakkebæk
Niels Erik Skakkebæk
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Hanne Frederiksen
Hanne Frederiksen
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Camilla Koch Ryrsø
Camilla Koch Ryrsø
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Arnold Matovu Dungu
Arnold Matovu Dungu
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
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Maria Hein Hegelund
Maria Hein Hegelund
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
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Daniel Faurholt-Jepsen
Daniel Faurholt-Jepsen
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Rikke Krogh-Madsen
Rikke Krogh-Madsen
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Birgitte Lindegaard
Birgitte Lindegaard
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Allan Linneberg
Allan Linneberg
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Line Lund Kårhus
Line Lund Kårhus
Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Thomas Benfield
Thomas Benfield
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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and etiology. Statistics The study population was characterized using descriptive statistics where categorical variables were reported as counts (%), parametric continuous variables were summarized using means with s.d. , and non
Iben Katinka Greiber
Iben Katinka Greiber
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Casper P Hagen
Casper P Hagen
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Alexander Siegfried Busch
Alexander Siegfried Busch
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Mikkel Grunnet Mieritz
Mikkel Grunnet Mieritz
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Lise Aksglæde
Lise Aksglæde
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Katharina Main
Katharina Main
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Kristian Almstrup
Kristian Almstrup
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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10407022 T>G (TT 684, TG 263, GG 24, minor allele frequency (MAF) 16%) and AMHR2 rs11170547 C>T (CC 777, CT 188, TT 12, MAF 11%). Distributions were consistent with Hardy–Weinberg equilibrium (Pearson’s χ 2 = 0.05, P = 0.830 and χ 2 = 0.03, P
Neil R Chappell
Neil R Chappell
Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA
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Beth Zhou
Beth Zhou
Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA
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Amy K Schutt
Amy K Schutt
Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA
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William E Gibbons
William E Gibbons
Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA
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Chellakkan S Blesson
Chellakkan S Blesson
Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA
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16 weeks using the A1cNow+ test kit (PTS Diagnostics, Indianapolis, IN, USA) following the manufacturer’s instructions. Due to the sub-fertile nature of the animal model, in order to study the oocyte, it was necessary to perform superovulation to
M P Schuijt
M P Schuijt
Department of Laboratory Medicine, Slingeland Hospital, Doetinchem, The Netherlands
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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C G J Sweep
C G J Sweep
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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R van der Steen
R van der Steen
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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A J Olthaar
A J Olthaar
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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N M M L Stikkelbroeck
N M M L Stikkelbroeck
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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H A Ross
H A Ross
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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A E van Herwaarden
A E van Herwaarden
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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calculated free testosterone in pregnant females with the formula of Ross et al. ( 21 ) was −0.01 ± 0.01 % (mean ± s.d. ), whereas with the formula of Vermeulen et al. ( 13 ) it was −1.7 ± 0.9% when a fixed albumin concentration of 43 g/L was used
Michael Ulm
Michael Ulm
University of Tennessee Health Science Center, Memphis, Tennessee, USA
West Cancer Center, Memphis, Tennessee, USA
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West Cancer Center, Memphis, Tennessee, USA
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Arvind V Ramesh
Arvind V Ramesh
White Station High School, Memphis, Tennessee, USA
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Keely M McNamara
Keely M McNamara
Tohoku University, Miyagi, Japan
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Suriyan Ponnusamy
Suriyan Ponnusamy
University of Tennessee Health Science Center, Memphis, Tennessee, USA
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Hironobu Sasano
Hironobu Sasano
Tohoku University, Miyagi, Japan
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Ramesh Narayanan
Ramesh Narayanan
University of Tennessee Health Science Center, Memphis, Tennessee, USA
West Cancer Center, Memphis, Tennessee, USA
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West Cancer Center, Memphis, Tennessee, USA
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respond to low levels of androgens. In addition, mutations in the AR LBD will cause the AR to be refractory to existing treatments. 3. Intra-tumoral androgen synthesis. Androgens such as androstenedione, and DHEA synthesized by the adrenals will be
Qiu-ming Yao
Qiu-ming Yao
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Bin Wang
Bin Wang
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Xiao-fei An
Xiao-fei An
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Jin-an Zhang
Jin-an Zhang
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Liumei Ding
Liumei Ding
Department of Clinical Laboratory, Jinshan Hospital of Fudan University, Shanghai, China
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the pooled RRs of T2DM associated with testosterone. The I 2 and the Cochran’s Q statistic were used to evaluate the heterogeneity ( 11 , 12 ). For the Q statistic, P < 0.10 suggested statistically significant heterogeneity. I 2 more than 50
Dafydd Aled Rees
Dafydd Aled Rees
Cardiff University, Cardiff, United Kingdom
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Deborah P Merke
Deborah P Merke
National Institutes of Health Clinical Center and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, USA
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Wiebke Arlt
Wiebke Arlt
MRC LMS, London, United Kingdom
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Aude Brac De La Perriere
Aude Brac De La Perriere
Hospices Civils de Lyon - GHE - Endocrinologie, Bron, France
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Angelica Linden Hirschberg
Angelica Linden Hirschberg
Karolinska Institute, Solna, Sweden
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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John Newell-Price
John Newell-Price
The University of Sheffield, Sheffield, United Kingdom
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Alessandro Prete
Alessandro Prete
University of Birmingham, Birmingham, United Kingdom
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Nicole Reisch
Nicole Reisch
Endokrinologie, Nephrologie und weitere Sektionen - Medizinische Klinik und Poliklinik IV - Campus Innenstadt, München, Germany
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Nike M Stikkelbroeck
Nike M Stikkelbroeck
Radboud University Nijmegen, Nijmegen, Netherlands
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Philippe A Touraine
Philippe A Touraine
University Hospitals Pitié Salpêtrière - Charles Foix, Paris, France
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Alex Lewis
Alex Lewis
Neurocrine Biosciences Inc, London, United Kingdom
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John Porter
John Porter
Neurocrine Biosciences Inc, London, United Kingdom
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Helen Coope
Helen Coope
Neurocrine Biosciences Inc, London, United Kingdom
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Richard J Ross
Richard J Ross
The University of Sheffield, Sheffield, United Kingdom
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recommended treatment guideline doses (25 mg/day) ( 4 ). Two thresholds of 17OHP control were analysed, based on whether patients’ 17OHP was above or below 36 nmol/L (3×ULN) and 12 nmol/L (ULN). Quadrant analysis was performed using the two-sided Fisher’s
Rohit Barnabas
Rohit Barnabas
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Swati Jadhav
Swati Jadhav
Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, India
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Anurag Ranjan Lila
Anurag Ranjan Lila
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Sirisha Kusuma Boddu
Sirisha Kusuma Boddu
Consultant Pediatric Endocrinology & Diabetes, Rainbow Children’s Hospital, Hyderabad, India
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Saba Samad Memon
Saba Samad Memon
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Sneha Arya
Sneha Arya
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Samiksha Chandrashekhar Hegishte
Samiksha Chandrashekhar Hegishte
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Manjiri Karlekar
Manjiri Karlekar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Virendra A Patil
Virendra A Patil
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Vijaya Sarathi
Vijaya Sarathi
Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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numbers and percentages, whereas continuous data were expressed as median and ranges as appropriate. Fisher’s exact or chi-square test was used to compare categorical variables, whereas the independent t -test or Mann–Whitney U- test was used to compare
Angela Köninger
Angela Köninger
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Philippos Edimiris
Philippos Edimiris
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Laura Koch
Laura Koch
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Antje Enekwe
Antje Enekwe
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Claudia Lamina
Claudia Lamina
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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Sabine Kasimir-Bauer
Sabine Kasimir-Bauer
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Rainer Kimmig
Rainer Kimmig
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Hans Dieplinger
Hans Dieplinger
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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range 0.5–2.6 nmol/l) and/or DHEAS (normal range 6–123 μg/dl) and/or androstenedione (normal range 0.3–3.3 ng/ml), and sonographically diagnosed polycystic ovaries (at least one ovary with at least 12 follicles with a diameter of 2–9 mm each or a volume
