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( 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ). In contrast, there has been comparatively little attention on MC replacement ( 12 , 22 , 23 ). Currently, the Endocrine Society’s guidelines recommend monitoring MC replacement through clinical
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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and etiology. Statistics The study population was characterized using descriptive statistics where categorical variables were reported as counts (%), parametric continuous variables were summarized using means with s.d. , and non
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10407022 T>G (TT 684, TG 263, GG 24, minor allele frequency (MAF) 16%) and AMHR2 rs11170547 C>T (CC 777, CT 188, TT 12, MAF 11%). Distributions were consistent with Hardy–Weinberg equilibrium (Pearson’s χ 2 = 0.05, P = 0.830 and χ 2 = 0.03, P
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16 weeks using the A1cNow+ test kit (PTS Diagnostics, Indianapolis, IN, USA) following the manufacturer’s instructions. Due to the sub-fertile nature of the animal model, in order to study the oocyte, it was necessary to perform superovulation to
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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calculated free testosterone in pregnant females with the formula of Ross et al. ( 21 ) was −0.01 ± 0.01 % (mean ± s.d. ), whereas with the formula of Vermeulen et al. ( 13 ) it was −1.7 ± 0.9% when a fixed albumin concentration of 43 g/L was used
West Cancer Center, Memphis, Tennessee, USA
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West Cancer Center, Memphis, Tennessee, USA
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respond to low levels of androgens. In addition, mutations in the AR LBD will cause the AR to be refractory to existing treatments. 3. Intra-tumoral androgen synthesis. Androgens such as androstenedione, and DHEA synthesized by the adrenals will be
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the pooled RRs of T2DM associated with testosterone. The I 2 and the Cochran’s Q statistic were used to evaluate the heterogeneity ( 11 , 12 ). For the Q statistic, P < 0.10 suggested statistically significant heterogeneity. I 2 more than 50
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recommended treatment guideline doses (25 mg/day) ( 4 ). Two thresholds of 17OHP control were analysed, based on whether patients’ 17OHP was above or below 36 nmol/L (3×ULN) and 12 nmol/L (ULN). Quadrant analysis was performed using the two-sided Fisher’s
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numbers and percentages, whereas continuous data were expressed as median and ranges as appropriate. Fisher’s exact or chi-square test was used to compare categorical variables, whereas the independent t -test or Mann–Whitney U- test was used to compare
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Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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range 0.5–2.6 nmol/l) and/or DHEAS (normal range 6–123 μg/dl) and/or androstenedione (normal range 0.3–3.3 ng/ml), and sonographically diagnosed polycystic ovaries (at least one ovary with at least 12 follicles with a diameter of 2–9 mm each or a volume