Tatsuya Kondo
Tatsuya Kondo
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Nobukazu Miyakawa
Nobukazu Miyakawa
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Sayaka Kitano
Sayaka Kitano
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Takuro Watanabe
Takuro Watanabe
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Rieko Goto
Rieko Goto
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Mary Ann Suico
Mary Ann Suico
Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Miki Sato
Miki Sato
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Yuki Takaki
Yuki Takaki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Masaji Sakaguchi
Masaji Sakaguchi
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Motoyuki Igata
Motoyuki Igata
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Junji Kawashima
Junji Kawashima
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Hiroyuki Motoshima
Hiroyuki Motoshima
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Takeshi Matsumura
Takeshi Matsumura
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Hirofumi Kai
Hirofumi Kai
Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Eiichi Araki
Eiichi Araki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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phenotype in metabolic diseases, such as metabolic syndrome and type 2 diabetes. These metabolic disturbances are closely associated with insulin resistance. Hepatic insulin resistance also causes dyslipidemia, oxidative stress, endoplasmic reticulum (ER
Hong-Fa Yan
Hong-Fa Yan
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Zhao-Yu Liu
Zhao-Yu Liu
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Zhi-Ang Guan
Zhi-Ang Guan
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Chuang Guo
Chuang Guo
College of Life and Health Sciences, Northeastern University, Shenyang, China
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associated oxidative stress are linked to the development of obesity-associated metabolic disturbances, including T2DM ( 5 ), metabolic syndrome ( 6 ), central adiposity and cardiovascular disease ( 7 ). Iron has been shown to be accumulated in the liver and
Rebeca Esquivel-Zuniga
Rebeca Esquivel-Zuniga
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
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Alan D Rogol
Alan D Rogol
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
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disease, anorexia nervosa, excessive exercise, chronic kidney disease, sickle cell disease and thalassemia, severe obesity, opioids); chronic stress Female Turner syndrome Premature ovarian insufficiency Kallmann syndrome Combined pituitary
Arno Téblick
Arno Téblick
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Ilse Vanhorebeek
Ilse Vanhorebeek
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Inge Derese
Inge Derese
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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An Jacobs
An Jacobs
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Renata Haghedooren
Renata Haghedooren
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Sofie Maebe
Sofie Maebe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Gerdien A Zeilmaker-Roest
Gerdien A Zeilmaker-Roest
Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Rotterdam, the Netherlands
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Enno D Wildschut
Enno D Wildschut
Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Rotterdam, the Netherlands
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Lies Langouche
Lies Langouche
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Greet Van den Berghe
Greet Van den Berghe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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stress doses of hydrocortisone (1.2 mg/day, ~200–300 mg/day human equivalent ( 2 )) resulted in further suppression of plasma ACTH concentrations after 7 days of critical illness as compared with infusion of placebo ( 3 ), without affecting plasma POMC
Xi Zhang
Xi Zhang
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China
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Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China
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Xiurong Shen
Xiurong Shen
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China
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Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China
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Wan Zhou
Wan Zhou
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Mengyun Xu
Mengyun Xu
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Yan Xing
Yan Xing
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Jianping Weng
Jianping Weng
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Shandong Ye
Shandong Ye
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Suowen Xu
Suowen Xu
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Zhi Zhang
Zhi Zhang
Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Wei Wang
Wei Wang
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
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, increased morbidity, and huge economic burdens. A variety of factors related to the pathophysiological processes of T2D including hyperglycemia, the formation of intracellular advanced glycation end products, oxidative stress, mitochondrial dysfunction, and
Chun-feng Lu
Chun-feng Lu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Wang-shu Liu
Wang-shu Liu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Xiao-qin Ge
Xiao-qin Ge
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Feng Xu
Feng Xu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Jian-bin Su
Jian-bin Su
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Xue-qin Wang
Xue-qin Wang
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Yan Wang
Yan Wang
Department of Geriatrics, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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species (ROS) in peripheral tissues ( 23 ). A prospective study that enrolled 21 GD patients revealed that oxidative stress indexes were associated with thyroid function, and restoration of euthyroidism could significantly decreased oxidative stress
Jesper Krogh
Jesper Krogh
Department of Endocrinology & Metabolism, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Peter Plomgaard
Peter Plomgaard
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
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Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
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Ruth Frikke-Schmidt
Ruth Frikke-Schmidt
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
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Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
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Sten Velschow
Sten Velschow
Fluisense ApS, Lillerød, Denmark
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Jesper Johannesen
Jesper Johannesen
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Pediatrics, Copenhagen University Hospital - Herlev & Gentofte, Copenhagen, Denmark
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Department of Pediatrics, Copenhagen University Hospital - Herlev & Gentofte, Copenhagen, Denmark
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Linda Maria Hilsted
Linda Maria Hilsted
Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
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Malene Schrøder
Malene Schrøder
Fluisense ApS, Lillerød, Denmark
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Endocrinology & Metabolism, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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), which require repeated venous sampling. The pathology of several other conditions such as major depression, bipolar disease, stress related to night shifts, nocturia, hypertension, and sleep disorders have all been claimed to include disrupted circadian
Lisa Arnetz
Lisa Arnetz
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Neda Rajamand Ekberg
Neda Rajamand Ekberg
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Kerstin Brismar
Kerstin Brismar
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Michael Alvarsson
Michael Alvarsson
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
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, 9) . Younger, healthy women have increased adrenal response to physiological stress compared with men due to a stimulatory effect of estrogen on the HPA axis (10) . Increased glucocorticoid levels or HPA axis activity may furthermore suppress growth
Karim Gariani
Karim Gariani
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland
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Pedro Marques-Vidal
Pedro Marques-Vidal
Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
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Gérard Waeber
Gérard Waeber
Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
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Peter Vollenweider
Peter Vollenweider
Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland
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associated with IR and cardiovascular risk factors ( 13 ). Several studies have shown that individuals with glucose intolerance or T2DM exhibit a significantly higher level of chronic stress and hormonal stress responses ( 14 , 15 ). Salivary cortisol has
Susan M Webb
Susan M Webb
IIB-Sant Pau, Research Center for Pituitary Diseases, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain
Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain
Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Jette Kristensen
Jette Kristensen
ePAG & Chair of Danish Addison Patient Association, Aarhus, Denmark
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Anna Nordenström
Anna Nordenström
Pediatric Endocrinology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
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Diana Vitali
Diana Vitali
ePAG & Chair SOD ITALIA - Italian Patients Organization for Septo Optic Dysplasia and other Neuroendocrine Conditions, Rome, Italy
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Vincent Amodru
Vincent Amodru
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics, Institut MarMaRa, Marseille, France
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Lenja Katharina Wiehe
Lenja Katharina Wiehe
EURORDIS - Rare Diseases Europe, Paris, France
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Matt Bolz-Johnson
Matt Bolz-Johnson
EURORDIS - Rare Diseases Europe, Paris, France
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, fits of rage, irritability Less frequently described: ‘unexplained’ very large placenta. Laryngeal ventricular hernia, change in smile Two different scenarios: - No suspicion of disease, problems thought to be related to stress, ageing, weight gain or
