Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Celine Corbisier de Meaultsart
Celine Corbisier de Meaultsart
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
Oregon Health and Science University, Portland, Oregon, USA
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Jim Scurry
Jim Scurry
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Nicole M Verrills
Nicole M Verrills
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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proliferation and migration in the normal endometrium, it has the potential, if overexpressed and/or activated, to promote abnormal cell growth and spread that is the hallmark of endometrial cancer ( Fig. 1 ). The prorenin receptor ((P)RR) is an integral
Joanna Klubo-Gwiezdzinska
Joanna Klubo-Gwiezdzinska
National Institute of Health, NIDDK, Office 10 Center Drive, Bethesda, Maryland, USA
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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John Costello Jr
John Costello Jr
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Kirk Jensen
Kirk Jensen
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Aneeta Patel
Aneeta Patel
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Rok Tkavc
Rok Tkavc
Department of Pathology, Uniformed Services University of the Health Sciences, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
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Douglas Van Nostrand
Douglas Van Nostrand
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Kenneth D Burman
Kenneth D Burman
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Leonard Wartofsky
Leonard Wartofsky
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Vasyl Vasko
Vasyl Vasko
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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in the damaged cells and tissues such as activation of DNA repair, activation of signal transduction, expression of radiation response genes and stimulation of proliferation ( 2 ). These pathways can be important for cell or tissue recovery after
Qinglei Yin
Qinglei Yin
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Zhou Jin
Zhou Jin
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yulin Zhou
Yulin Zhou
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Dalong Song
Dalong Song
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Chenyang Fu
Chenyang Fu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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FengJiao Huang
FengJiao Huang
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Shu Wang
Shu Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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of autoimmunity- and inflammation-related processes, including nuclear factor-κB and toll-like receptor signaling, cytokine expression, and immune cell proliferation and differentiation ( 15 , 16 , 17 , 18 , 19 ). It has also been demonstrated
María L Bacigalupo
María L Bacigalupo
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Verónica G Piazza
Verónica G Piazza
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Nadia S Cicconi
Nadia S Cicconi
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Pablo Carabias
Pablo Carabias
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Andrzej Bartke
Andrzej Bartke
Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA
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Yimin Fang
Yimin Fang
Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA
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Ana I Sotelo
Ana I Sotelo
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Gabriel A Rabinovich
Gabriel A Rabinovich
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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María F Troncoso
María F Troncoso
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Johanna G Miquet
Johanna G Miquet
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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upregulation of GAL1 promotes HepG2 cell proliferation and epithelial-mesenchymal transition in vitro , and tumor growth and metastasis in vivo ( 24 , 28 , 29 ). We first evaluated GAL1 protein expression in HepG2 cells treated with GH for different times
Małgorzata Fuksiewicz
Małgorzata Fuksiewicz
Department of Pathology and Laboratory Diagnostics, Laboratory of Tumor Markers, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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Maria Kowalska
Maria Kowalska
Department of Pathology and Laboratory Diagnostics, Laboratory of Tumor Markers, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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Agnieszka Kolasińska-Ćwikła
Agnieszka Kolasińska-Ćwikła
Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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Jarosław B Ćwikła
Jarosław B Ćwikła
The Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland
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Łukasz Sawicki
Łukasz Sawicki
Department of Clinical Surgery, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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Katarzyna Roszkowska-Purska
Katarzyna Roszkowska-Purska
Department of Pathology, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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Joanna Drygiel
Joanna Drygiel
Department of Nutrition, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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Beata Kotowicz
Beata Kotowicz
Department of Pathology and Laboratory Diagnostics, Laboratory of Tumor Markers, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
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) G3 5/59 (9) 1/48 (2) Indeks proliferation (Ki67) =3 33/59 (56) 32/48 (67) 3–20 21/59 (35) 15/48 (31) >20 5/59 (8) 1/48 (2) Baseline liver involvement Yes 21/59 (35) 22/48 (46
Xi Cao
Xi Cao
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Ming Lu
Ming Lu
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Rong-Rong Xie
Rong-Rong Xie
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Li-Ni Song
Li-Ni Song
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Wei-Li Yang
Wei-Li Yang
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Zhong Xin
Zhong Xin
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Guang-Ran Yang
Guang-Ran Yang
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Jin-Kui Yang
Jin-Kui Yang
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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( 40 ), and thyroid eye disease orbital fibroblast proliferation ( 41 ). Similarly, TSH might promote vascular or other layer proliferation in the retina. Moreover, there might be other possible mechanisms underlying the regulation of DME by TSH, which
Rong Xu
Rong Xu
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Difei Lian
Difei Lian
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yan Xie
Yan Xie
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Lin Mu
Lin Mu
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yali Wu
Yali Wu
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Zhilei Chen
Zhilei Chen
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Baoyu Zhang
Baoyu Zhang
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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proliferation of osteoblasts through inhibiting the expression of Runx2 and Osterix (Runx2 and Osterix are key transcriptional regulators of osteoblast differentiation) but also negatively affect their activity, viability, and apoptosis, resulting in a decrease
Cecília Cristelo
Cecília Cristelo
i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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Alexandra Machado
Alexandra Machado
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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Bruno Sarmento
Bruno Sarmento
i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal
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CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal
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Francisco Miguel Gama
Francisco Miguel Gama
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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tolerance therapies, the protection of β cells and selective stimulation of their proliferation or reprograming of non-β cells into functional β cells ( 19 ). Although islets have limited regenerative capacity it has been found that, within islets, α cells
Maria Mizamtsidi
Maria Mizamtsidi
Department of Endocrinology, Diabetes and Metabolism, Hellenic Red Cross Hospital, Athens, Greece
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Constantinos Nastos
Constantinos Nastos
Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece
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George Mastorakos
George Mastorakos
Unit of Endocrinology, Diabetes and Metabolism, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece
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Roberto Dina
Roberto Dina
Department of Pathology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
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Ioannis Vassiliou
Ioannis Vassiliou
Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece
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Maria Gazouli
Maria Gazouli
Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Fausto Palazzo
Fausto Palazzo
Department of Thyroid and Endocrine Surgery, Imperial College London, London, UK
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proliferation of parenchymal cells, with little or no extracellular fat or nodular development consisting mainly by chief cells, although foci of oncocytes and clear cells may be admixed ( 37 ). There are two major types of histological hyperplastic
Vita Birzniece
Vita Birzniece
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Teresa Lam
Teresa Lam
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Mark McLean
Mark McLean
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Navneeta Reddy
Navneeta Reddy
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Haleh Shahidipour
Haleh Shahidipour
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Amy Hayden
Amy Hayden
School of Medicine, Western Sydney University, New South Wales, Australia
Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Howard Gurney
Howard Gurney
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Glenn Stone
Glenn Stone
School of Computing, Engineering and Mathematics, Western Sydney University, New South Wales, Australia
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Rikke Hjortebjerg
Rikke Hjortebjerg
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Jan Frystyk
Jan Frystyk
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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pathway ( 13 , 14 , 15 , 16 ). There is increasing evidence that metformin, by modulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs), may inhibit cancer proliferation and spread. Recent studies show that metformin inhibits
