Monika Karczewska-Kupczewska
Monika Karczewska-Kupczewska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Agnieszka Nikołajuk
Agnieszka Nikołajuk
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Radosław Majewski
Radosław Majewski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Remigiusz Filarski
Remigiusz Filarski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Magdalena Stefanowicz
Magdalena Stefanowicz
Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Natalia Matulewicz
Natalia Matulewicz
Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Marek Strączkowski
Marek Strączkowski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Introduction Obesity predisposes to the development of type 2 diabetes, dyslipidemia, hypertension, atherosclerosis, several types of cancer and other disorders. Insulin resistance is a major pathophysiological link between obesity and its
Wenjun Long
Wenjun Long
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Tuo Zhou
Tuo Zhou
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xiuping Xuan
Xiuping Xuan
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Qiuli Cao
Qiuli Cao
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Zuojie Luo
Zuojie Luo
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Yingfen Qin
Yingfen Qin
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Qin Ning
Qin Ning
Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xiaoping Luo
Xiaoping Luo
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xuemei Xie
Xuemei Xie
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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growth (CG-IUGR) is much higher than that in normal people ( 10 , 11 ). Insulin resistance has been considered as an early manifestation as well as a crucial mechanism for metabolic disturbance in later life of individuals with CG-IUGR ( 12 , 13 , 14
Silan Zheng
Silan Zheng
School of Medicine, Xiamen University, Xiamen, China
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Meifeng Tong
Meifeng Tong
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Lianqin Dong
Lianqin Dong
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
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Chunmin Du
Chunmin Du
School of Medicine, Xiamen University, Xiamen, China
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Xin Zheng
Xin Zheng
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Liying Wang
Liying Wang
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Peiying Huang
Peiying Huang
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Wei Liu
Wei Liu
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Mingzhu Lin
Mingzhu Lin
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Changqin Liu
Changqin Liu
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
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The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
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accurately predict insulin resistance (IR), prediabetes, and type 2 diabetes mellitus (T2DM) ( 15 , 16 , 17 , 18 ). In the present study, we aimed to explore whether the new adiposity indices (LAP, VAI, and TyG) could predict the risk of HS quantified by
Tatsuya Kondo
Tatsuya Kondo
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Nobukazu Miyakawa
Nobukazu Miyakawa
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Sayaka Kitano
Sayaka Kitano
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Takuro Watanabe
Takuro Watanabe
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Rieko Goto
Rieko Goto
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Mary Ann Suico
Mary Ann Suico
Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Miki Sato
Miki Sato
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Yuki Takaki
Yuki Takaki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Masaji Sakaguchi
Masaji Sakaguchi
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Motoyuki Igata
Motoyuki Igata
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Junji Kawashima
Junji Kawashima
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Hiroyuki Motoshima
Hiroyuki Motoshima
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Takeshi Matsumura
Takeshi Matsumura
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Hirofumi Kai
Hirofumi Kai
Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Eiichi Araki
Eiichi Araki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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phenotype in metabolic diseases, such as metabolic syndrome and type 2 diabetes. These metabolic disturbances are closely associated with insulin resistance. Hepatic insulin resistance also causes dyslipidemia, oxidative stress, endoplasmic reticulum (ER
Hong Wang
Hong Wang
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Jie Cao
Jie Cao
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Jian-bin Su
Jian-bin Su
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Xue-qin Wang
Xue-qin Wang
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Dong-mei Zhang
Dong-mei Zhang
Medical Research Center, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China
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Xiao-hua Wang
Xiao-hua Wang
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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the formation of glycosylation end products (AGEs) collectively contribute to hypercoagulation in T2D ( 2 ). Insulin resistance, also termed 'reduced insulin sensitivity', is of central importance in the pathogenesis and progression of T2D and
Karim Gariani
Karim Gariani
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Geneviève Drifte
Geneviève Drifte
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Irène Dunn-Siegrist
Irène Dunn-Siegrist
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Jérôme Pugin
Jérôme Pugin
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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-activated receptor α (PPARα) and PPARγ respectively (1, 6) . FGF21 has emerged as a key regulator in the metabolism of glucose and lipids (6, 7, 8) . FGF21 may have a potential role as a therapeutic agent for conditions associated with insulin resistance as it has
Christian Trummer
Christian Trummer
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Stefan Pilz
Stefan Pilz
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Verena Schwetz
Verena Schwetz
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Barbara Obermayer-Pietsch
Barbara Obermayer-Pietsch
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Elisabeth Lerchbaum
Elisabeth Lerchbaum
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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, evidence is accumulating that vitamin D deficiency is also a risk marker for insulin resistance ( 3 ), cardiovascular disease ( 4 ), infectious and autoimmune diseases ( 1 ), cancer ( 5 ), increased mortality ( 2 ) as well as decreased fertility ( 6
Lars Peter Sørensen
Lars Peter Sørensen
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Tina Parkner
Tina Parkner
Department of Endocrinology and Internal Medicine, Department of Clinical Biochemistry, Department of Biostatistics, Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
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Esben Søndergaard
Esben Søndergaard
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Bo Martin Bibby
Bo Martin Bibby
Department of Endocrinology and Internal Medicine, Department of Clinical Biochemistry, Department of Biostatistics, Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
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Holger Jon Møller
Holger Jon Møller
Department of Endocrinology and Internal Medicine, Department of Clinical Biochemistry, Department of Biostatistics, Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
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Søren Nielsen
Søren Nielsen
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Introduction Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes mellitus (T2DM), but the adverse metabolic consequences of obesity vary between individuals (1) . The mechanisms underlying obesity
Ling Zhou
Ling Zhou
Cangzhou Central Hospital, Cangzhou, Hebei, China
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Ruixue Zhang
Ruixue Zhang
Cangzhou Central Hospital, Cangzhou, Hebei, China
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Shuangyan Yang
Shuangyan Yang
Cangzhou Central Hospital, Cangzhou, Hebei, China
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Yaguang Zhang
Yaguang Zhang
Cangzhou Central Hospital, Cangzhou, Hebei, China
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Dandan Shi
Dandan Shi
Cangzhou Central Hospital, Cangzhou, Hebei, China
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. 1A , B , C and D ), which was consistent with previous publication showing that non-pregnant C57BL/KsJ-Lep db/+ mice usually did not exhibit diabetic symptoms, such as hyperglycemia and insulin resistance ( 17 ). Nevertheless, AS-IV also had no
Xiuzhen Hou
Xiuzhen Hou
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Junfeng Zhang
Junfeng Zhang
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Hehong Ma
Hehong Ma
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Ming Li
Ming Li
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Pei Wang
Pei Wang
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Introduction Gestational diabetes mellitus (GDM) is primarily resulted from insulin resistance and glucose intolerance during pregnancy, affecting 7% of pregnant women globally ( 1 , 2 ). GDM causes higher risks of diabetes, obesity and
