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Elizabeth J de Koster Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Olga Husson Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands
Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
Division of Clinical Studies, Institute of Cancer Research, London, UK

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Eveline W C M van Dam Department of Internal Medicine, Division of Endocrinology, location VU University Medical Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands

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G Sophie Mijnhout Department of Internal Medicine, Isala Hospital, Zwolle, The Netherlands

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Romana T Netea-Maier Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, The Netherlands

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Wim J G Oyen Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands
Department of Biomedical Sciences and Humanitas Clinical and Research Centre, Department of Nuclear Medicine, Humanitas University, Milan, Italy

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Marieke Snel Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands

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Lioe-Fee de Geus-Oei Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands
Biomedical Photonic Imaging Group, University of Twente, Enschede, The Netherlands

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Dennis Vriens Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands

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for the EfFECTS trial study group
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3, 6, and 12 months relative to baseline. The ThyPRO composite QoL score showed worse HRQoL at 3 months as compared to baseline. Finally, an unexpected increase in hyperthyroid symptoms was observed at 12 months as compared to baseline in patients

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Jakub Supronik Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Małgorzata Szelachowska Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Adam Kretowski Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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autoimmune thyroid disease (ATD). It is mainly associated with Graves’ disease (GD) but may also be seen in patients with chronic lymphocytic thyroiditis. Most commonly, it accompanies hyperthyroidism, but it may also occur in euthyroid patients, preceding

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Lia Ferreira Department of Endocrinology, Centro Hospitalar do Porto, Porto, Portugal

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João Silva Department of Endocrinology, Hospital das Forças Armadas, Lisboa, Portugal

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Susana Garrido Department of Endocrinology, Centro Hospitalar Tâmega e Sousa, Porto, Portugal

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Carlos Bello Department of Endocrinology, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal

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Diana Oliveira Department of Endocrinology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

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Hélder Simões Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Isabel Paiva Department of Endocrinology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

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Joana Guimarães Department of Endocrinology, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal

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Marta Ferreira Department of Endocrinology, Centro Hospitalar de Leiria, Leiria, Portugal

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Teresa Pereira Department of Endocrinology, Centro Hospitalar de Leiria, Leiria, Portugal

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Rita Bettencourt-Silva Department of Endocrinology, Centro Hospitalar de São João, Porto, Portugal

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Ana Filipa Martins Department of Endocrinology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal

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Tiago Silva Department of Endocrinology, Hospital Garcia da Orta, Lisboa, Portugal

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Vera Fernandes Department of Endocrinology, Hospital de Braga, Braga, Portugal

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Maria Lopes Pereira Department of Endocrinology, Hospital de Braga, Braga, Portugal

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Adrenal Tumors Study Group of the Portuguese Society of Endocrinology Department of Endocrinology, Centro Hospitalar do Porto, Porto, Portugal

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characterized by two or more concurrent autoimmune endocrinopathies, such as AD, autoimmune hypo- or hyperthyroidism and type 1 diabetes mellitus (DM) ( 14 ). Isolated PAI and APS-2 share the same pattern of complex inheritance ( 7 ). To date, no data have

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Josephina G Kuiper PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands

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Aline C Fenneman Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Anne H van der Spek Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Elena Rampanelli Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Max Nieuwdorp Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Myrthe P P van Herk-Sukel Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands

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Valery E P P Lemmens Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands

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Ernst J Kuipers Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands

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Ron M C Herings PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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protection given by more than 10 years of use. However, the study did not report on cumulative dosage, tumour location, or staging. In this regard, a previous study by L’Heureux et al. found that both hypothyroidism and hyperthyroidism were inversely

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Maria Stelmachowska-Banaś Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Polska, Poland

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Izabella Czajka-Oraniec Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Polska, Poland

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(hyperthyroidism)  Any-grade 0.9% (Ipi) 3.01% (Niv) 10.16% (Ipi + Niv) Almutairi et al. (18) 3.34% (Pem) 11.11% (Ipi + Pem) 0.20% NA NA Xu et al. (20) 1.4% (Ipi) 2.3% (Ave) 9.4% (Ipi + Niv) de

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Huixing Liu Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Daoquan Peng Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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stimulate carnitine palmitoyltransferase Iα (CPT1A), a rate-limiting β-oxidation enzyme ( 40 ). Accordingly, CPT1A mRNA and enzyme activity in the hyperthyroidism animal livers increase significantly ( 41 ); CPT1A is inhibited in the hypothyroidism mice ( 42

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Peter Wolf Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Yvonne Winhofer Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Martin Krššák Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

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Michael Krebs Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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acutely decompensated heart failure, in which subclinical hypothyroidism, but not subclinical hyperthyroidism independently predicts adverse cardiovascular outcomes, including cardiac death and re-hospitalization for heart failure ( 49 ). Hemodynamic

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Clara Lundetoft Clausen Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, Denmark

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Trine Holm Johannsen Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark

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Linda Maria Hilsted Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark

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Niels Erik Skakkebæk Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark

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Pal Bela Szecsi Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark

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Lise Pedersen Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark

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Thomas Benfield Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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alterations in the hormonal secretion from the thyroid gland ( 2 , 3 , 4 ). Studies have shown varying degrees of thyroid dysfunction among patients with COVID-19 infection with 5–20% being hyperthyroid and up to 5% being hypothyroid ( 5 , 6 , 7 , 8 , 9

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Yun Cai Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Jieni Yan Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Yong Gu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Heng Chen Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Yang Chen Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Xinyu Xu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Mei Zhang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Liping Yu Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Xuqin Zheng Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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hyperthyroidism, while TGAb and TPOAb are more characteristic for HT, which is correlated with thyroidal damage and lymphocytic inflammation ( 1 , 2 ). Individuals with AITD may be associated with other autoimmune diseases, of which type 1 diabetes mellitus (T1

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Chenjia Tang Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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Yanting Dong Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Department of Endocrinology, Suichang County Hospital of Traditional Chinese Medicine, Lishui, China

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Lusi Lu Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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Nan Zhang Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

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uptake; (4) transient hyperthyroidism; and (5) hypoechoic areas with blurred margins on thyroid ultrasonography. For patients who did not meet the aforementioned criteria but were suspected of SAT, fine-needle aspiration and cytology of the thyroid were

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