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Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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the GnRH pulse generator during pregnancy and contributes in that way to the decrease in pituitary gonadotrophins causing a decrease in AMH. Fetal growth is dependent on adequate development of the placenta ( 52 ). Korevaar et al. showed that a
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= −3.74, P < 0.0002). (B) GO analysis showed that all upregulated genes in the in vivo 1-h Dex treatment group were highly associated with neural cell development and function. The fold change used for heatmaps was calculated based on FPKM +0.001. S
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regulates many fundamental processes during development and homeostasis of a wide range of tissues. As a consequence, deregulation of this pathway has been linked to multiple human disorders, from congenital syndromes to cancer ( 1 , 2 , 3 ). NOTCH
Center for International Health, University of Bergen, Bergen, Norway
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Department of Microbiology, Innlandet Hospital Trust, Lillehammer, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Research, Innlandet Hospital Trust, Lillehammer, Norway
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Background Optimal thyroid function during pregnancy is essential for both the mother and the developing fetus since thyroid hormones regulate the metabolism, growth, maintenance of pregnancy and development of the fetal CNS ( 1 ). During
Office for Rare Conditions, Royal Hospital for Children & Queen Elizabeth University Hospital, Glasgow, UK
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Department of Paediatric Endocrinology, Ghent University Hospital, Ghent, Belgium
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Department of Medicine & Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam, the Netherlands
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Office for Rare Conditions, Royal Hospital for Children & Queen Elizabeth University Hospital, Glasgow, UK
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
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(91%) 66 21 (2, 27) 0.1 (0, 1.3) 1.2 Growth and obesity 16 32 (12%) 225 (88%) 257 19 (5, 27) 0.4 (0, 5.6) 4.8 Pituitary 17 176 (51%) 168 (49%) 344 22 (4, 27) 0.4 (0, 8.7) 4.8 Sex development 20
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, nilutamide and bicalutamide) reduces the risk of PC death by 10–30% compared to castration alone ( 8 ). Through the development of the 2nd-generation AR antagonists such as enzalutamide and apalutamide and the steroidogenesis inhibitor abiraterone acetate
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diagnosed at a metastatic stage and not curable by surgery ( 5 , 6 , 7 , 8 ). In addition, over 40% of sporadic (non-familial) PNETs also show mutations in the MEN1 gene ( 8 , 9 ). Thus, MEN1 mutations are frequently associated with PNET development
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intracellular signaling. Mutations in the menin gene cause the development of multiple endocrine neoplasia type 1 (MEN1) syndrome. This autosomal dominant disease is characterized by the formation of multiple tumors, predominantly located in the endocrine glands
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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shown that HT development depends on an immune defect in an individual with genetic susceptibility together with environmental factors ( 2 ), such as iodine, selenium, smoking, and medications (e.g. amiodarone, alumtuzumab, iplimumab, interferon alpha
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Introduction The purpose of this review is to compile and discuss findings related to the role of thyroid hormones (THs) in the development, physiology, and pathology of the prostate gland. The study of the prostate is of interest in the field