Sidsel Mathiesen
Sidsel Mathiesen
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Kaspar Sørensen
Kaspar Sørensen
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Marianne Ifversen
Marianne Ifversen
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Casper P Hagen
Casper P Hagen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Jørgen Holm Petersen
Jørgen Holm Petersen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Klaus Müller
Klaus Müller
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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well as fatigue and depression ( 23 ) – conditions that are frequently reported in these patients ( 24 , 25 , 26 ). The gonadotropin levels remained within normal limits until the onset of puberty, as previously shown by others ( 4 , 5 , 7
Laura J Reid
Laura J Reid
Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
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Bala Muthukrishnan
Bala Muthukrishnan
Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
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Dilip Patel
Dilip Patel
Department of Radiology, Royal Infirmary of Edinburgh, Edinburgh, UK
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Mike S Crane
Mike S Crane
Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh, UK
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Murat Akyol
Murat Akyol
Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
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Andrew Thomson
Andrew Thomson
Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK
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Jonathan R Seckl
Jonathan R Seckl
Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
Centre for Cardiovascular Science, Queen’s Medical Research Unit, University of Edinburgh, Edinburgh, UK
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Centre for Cardiovascular Science, Queen’s Medical Research Unit, University of Edinburgh, Edinburgh, UK
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Fraser W Gibb
Fraser W Gibb
Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
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Fatigue at presentation 610 145/610 (23.8%) Weakness at presentation 610 29/610 (4.8%) Memory impairment at presentation 610 61/610 (10%) Depression at presentation 610 81/610 (13.4%) Polydipsia at
Lijuan Yuan
Lijuan Yuan
Department of Biochemistry and Molecular Biology, Center for DNA Typing, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Xihui Chen
Xihui Chen
Department of Biochemistry and Molecular Biology, Center for DNA Typing, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Ziyu Liu
Ziyu Liu
Department of Microbiology, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Dan Wu
Dan Wu
Department of Biochemistry and Molecular Biology, Center for DNA Typing, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Jianguo Lu
Jianguo Lu
Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Guoqiang Bao
Guoqiang Bao
Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Sijia Zhang
Sijia Zhang
Department of Biochemistry and Molecular Biology, Center for DNA Typing, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Lifeng Wang
Lifeng Wang
Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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Yuanming Wu
Yuanming Wu
Department of Biochemistry and Molecular Biology, Center for DNA Typing, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China
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levels was responsible for the gender difference of asthma ( 51 , 52 ), rhinitis ( 52 ) and depression ( 53 ) among other conditions. Estrogen has been shown to increase the risk of pulmonary hypertension ( 54 ) but promoted fat metabolism and protected
Jean-Benoît Corcuff
Jean-Benoît Corcuff
Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France
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Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France
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Laurence Chardon
Laurence Chardon
Department of Biochemistry, Edouard Herriot Hospital, Lyon, France
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Ines El Hajji Ridah
Ines El Hajji Ridah
Biomnis, Lyon, France
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Julie Brossaud
Julie Brossaud
Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France
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Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France
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: diazepam, phenobarbital, piperazine, methamphetamine… ( 44 , 45 , 46 , 47 ). In humans, desipramine and zimeldine mildly reduced 5-HIAA concentrations in the cerebrospinal fluid (CSF) ( 48 ). Isoniazid given for depression was also suspected of modifying
Dorte Glintborg
Dorte Glintborg
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Katrine Hass Rubin
Katrine Hass Rubin
Open Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
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Simon Bang Mohr Kristensen
Simon Bang Mohr Kristensen
Open Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
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Øjvind Lidegaard
Øjvind Lidegaard
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Guy T’Sjoen
Guy T’Sjoen
Department of Endocrinology and Center for Sexology and Gender, Ghent University Hospital, Gent, Belgium
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Aisa Burgwal
Aisa Burgwal
Department of Endocrinology and Center for Sexology and Gender, Ghent University Hospital, Gent, Belgium
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Malene Hilden
Malene Hilden
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Centre for Gender Identity, Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Centre for Gender Identity, Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Marianne Skovsager Andersen
Marianne Skovsager Andersen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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medicine support system in Denmark reimburses only a percentage of the price for gender-affirming hormonal treatment. Quality of life is impaired in many persons with incongruent gender identity ( 2 , 3 ) and the risk of depression ( 4 ) and suicide ( 5
Britt J van Keulen
Britt J van Keulen
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Conor V Dolan
Conor V Dolan
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Bibian van der Voorn
Bibian van der Voorn
Department of Pediatric Endocrinology, Sophia Kinderziekenhuis, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Ruth Andrew
Ruth Andrew
Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
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Brian R Walker
Brian R Walker
Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
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Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
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Hilleke Hulshoff Pol
Hilleke Hulshoff Pol
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
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Dorret I Boomsma
Dorret I Boomsma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Joost Rotteveel
Joost Rotteveel
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Martijn J J Finken
Martijn J J Finken
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Introduction Males and females differ in their susceptibility to develop specific diseases. While females are more likely to develop auto-immune diseases and neuropsychiatric disorders like anxiety and depression, males are more susceptible to
Rama Lakshman
Rama Lakshman
Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
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Charlotte Boughton
Charlotte Boughton
Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
Cambridge University Hospitals NHS Foundation Trust, Wolfson Diabetes and Endocrine Clinic, Cambridge, UK
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Cambridge University Hospitals NHS Foundation Trust, Wolfson Diabetes and Endocrine Clinic, Cambridge, UK
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Roman Hovorka
Roman Hovorka
Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
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glycaemic targets ( 4 ), and the high management burden associated with the condition can lead to reduced quality of life, burnout, diabetes distress, and depression ( 5 ). There have been rapid advancements in diabetes technology since the discovery of
Herjan J T Coelingh Bennink
Herjan J T Coelingh Bennink
Pantarhei Oncology, Zeist, The Netherlands
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Jan Krijgh
Jan Krijgh
Pantarhei Oncology, Zeist, The Netherlands
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Jan F M Egberts
Jan F M Egberts
Terminal 4 Communications, Hilversum, The Netherlands
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Maria Slootweg
Maria Slootweg
Independent Consultant, Zeist, The Netherlands
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Harm H E van Melick
Harm H E van Melick
Department of Urology, St. Antonius Hospital, Nieuwegein, The Netherlands
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Erik P M Roos
Erik P M Roos
Department of Urology, Antonius Hospital, Sneek, The Netherlands
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Diederik M Somford
Diederik M Somford
Department of Urology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
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Yvette Zimmerman
Yvette Zimmerman
Pantarhei Oncology, Zeist, The Netherlands
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Iman J Schultz
Iman J Schultz
Pantarhei Oncology, Zeist, The Netherlands
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Noel W Clarke
Noel W Clarke
The Christie and Salford Royal NHS Foundation Trusts, Manchester, UK
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R Jeroen A van Moorselaar
R Jeroen A van Moorselaar
Department of Urology, Amsterdam UMC, VU University, Amsterdam, The Netherlands
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Frans M J Debruyne
Frans M J Debruyne
Andros Clinics, Arnhem, The Netherlands
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important estrogen in men, ADT causes serious estrogen deficiency, which is heavily underestimated and results in subjective symptoms such as hot flushes and sweats, arthralgia, fatigue, mood changes and depression, sleep disturbances, cognition problems and
Ladan Younesi
Ladan Younesi
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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Zeinab Safarpour Lima
Zeinab Safarpour Lima
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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Azadeh Akbari Sene
Azadeh Akbari Sene
Department of Obstetrics and Gynecology, IVF Fellowship, Shahid Akbar-Abadi Hospital IVF Center, Iran University of Medical Sciences, Tehran, Iran
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Zahra Hosseini Jebelli
Zahra Hosseini Jebelli
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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Ghazaleh Amjad
Ghazaleh Amjad
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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, where they are more at risk for depression and anxiety ( 13 ). Determination of diagnostic criteria for PCOS plays a key role in early diagnosis and treatment of this condition. Since the polycystic ovary is an important component of the clinical
Emmanuel K Fai
Emmanuel K Fai
University of Maryland Medical Center Midtown Campus, Baltimore, Maryland, USA
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Cheryl Anderson
Cheryl Anderson
Walden University, Minneapolis, Minnesota, USA
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Victor Ferreros
Victor Ferreros
Walden University, Minneapolis, Minnesota, USA
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-taking behavior under volitional control ( 12 , 13 ), African Americans with type 2 diabetes and major psychiatric disorders such as major depression and schizophrenia were excluded from the study. Results Descriptive statistics Regarding the age
