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Magaly Zappa Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France

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Olivia Hentic Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France

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Marie-Pierre Vullierme Department of Radiology, AP-HP, Clichy, France

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Matthieu Lagadec Department of Radiology, AP-HP, Clichy, France

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Maxime Ronot Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France

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Philippe Ruszniewski Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France

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Valérie Vilgrain Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France

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effect of octreotide LAR ( 4 , 6 , 9 ). In most of these studies, the liver tumour burden was evaluated by a visual semi-quantitative assessment of the total tumour volume in the liver on CT scan and/or MRI, categorised into three to five classes by

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Yiqiang Huang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Lin-ang Wang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Qiubo Xie Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Jian Pang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Luofu Wang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Yuting Yi Geneplus-Beijing Institute, Beijing, People’s Republic of China

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Jun Zhang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Yao Zhang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Rongrong Chen Geneplus-Beijing Institute, Beijing, People’s Republic of China

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Weihua Lan Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Dianzheng Zhang Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA

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Jun Jiang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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approximately two times of the normal level (72 µmol/24 h urine; normal level <35 µmol/24 h urine) ( Table 1 ). Although craniocerebral MRI revealed no abnormalities, ultrasonography results suggest thyroid nodules and hypertensive heart disease. Enhanced CT

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Tristan Avril Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France

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Quentin Hennocq Datascience platform, Imagine Institute, Université Paris Cité, Paris, France

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Anne-Sophie Lambert Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France

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Juliane Leger Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France
Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France

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Dominique Simon Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France

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Laetitia Martinerie Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France
Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France
Inserm UMR1185, Le Kremlin Bicetre, Paris, France

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Claire Bouvattier Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France
Inserm UMR1185, Le Kremlin Bicetre, Paris, France
Paris-Saclay University, Paris, France

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cerebral magnetic resonance imaging (MRI), and genetic analysis was performed for all the cases. Paper or digital files (Orbis software) were collected retrospectively. The closest clinical visit was used for the data collection. The clinical data

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Benedetta Zampetti Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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Erika Grossrubatscher Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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Paolo Dalino Ciaramella Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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Edoardo Boccardi Department of Neuroradiology, Ospedale Niguarda, Milano, Italy

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Paola Loli Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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-enhanced MRI of the pituitary with specific protocols (which represents the most accurate imaging modality) still has limited power in identifying subcentimeter ACTH-secreting microadenomas and, in addition, it identifies 10–20% of nonfunctioning pituitary

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C L Bodinham
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L Smith
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E L Thomas Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK

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J D Bell Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK

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J R Swann Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK

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A Costabile Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK

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D Russell-Jones
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A M Umpleby
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M D Robertson
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analysis using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to investigate changes in body fat depot distribution, and a meal tolerance test (MTT) combined with arterio-venous (A-V) sampling across muscle tissue, for the first

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Solène Castellnou Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France

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Alexandre Vasiljevic Université Lyon 1, Villeurbanne, France
Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Véronique Lapras Service de Radiologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France

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Véronique Raverot Laboratoire d’Hormonologie, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France

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Eudeline Alix Département de Cytogénétique, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France

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Françoise Borson-Chazot Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France

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Emmanuel Jouanneau Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
Service de Neurochirurgie, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France

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Gérald Raverot Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Hélène Lasolle Service d’Endocrinologie, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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, preoperative hormonal assessment and pituitary MRI, were collected. Five patients were pre-treated with anticortisolic drugs before their surgery, either by ketoconazole ( n  = 4) or mitotane ( n  = 1). Corticotroph tumors were reported as silent when no

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Maria Stelmachowska-Banaś Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Polska, Poland

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Izabella Czajka-Oraniec Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Polska, Poland

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-stimulating hormone; fT3, free triiodothyronine; fT4, free thyroxine; GCSs, glucocorticoids; HbA1c, hemoglobin A1c; K, potassium; LH, luteinizing hormone; MRI, magnetic resonance imaging; Na, sodium; P, phosphorus; PTH, parathyroid hormone; SST, short Synacthen test

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Dirk-Jan van Beek Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Rachel S van Leeuwaarde Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Carolina R C Pieterman Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Menno R Vriens Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Gerlof D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Parelsnoer Institute, Utrecht, The Netherlands

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the DutchMEN Study Group
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mutation. Biochemical a Imaging a Surgery a Pathology a Medication a pHPT Calcium (ionized/total) PTHAlbumin25-OH vitamin D Conventional imaging: Neck ultrasound/CT/MRI (number of abnormalities) Functional imaging

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Hélène Lasolle Fédération d’Endocrinologie, Centre de Référence Maladies Rares Hypophysaires HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
INSERM U1052; CNRS UMR5286; Cancer Research Centre of Lyon, Lyon, France

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Amandine Ferriere Service d’endocrinologie, diabète et nutrition, Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France
UFR Sciences médicales, Université de Bordeaux, Bordeaux, France

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Alexandre Vasiljevic Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
INSERM U1052; CNRS UMR5286; Cancer Research Centre of Lyon, Lyon, France
Centre de Pathologie et de Neuropathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France

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Sandrine Eimer UFR Sciences médicales, Université de Bordeaux, Bordeaux, France
Service d’anatomo-pathologie, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France

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Marie-Laure Nunes Service d’endocrinologie, diabète et nutrition, Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France

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Antoine Tabarin Service d’endocrinologie, diabète et nutrition, Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France
UFR Sciences médicales, Université de Bordeaux, Bordeaux, France

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evaluations of care: a clinical evaluation using a non-validated standardized 20-point score that is used in our department (4 points for asthenia, headache, sweating, arthralgia and swelling, respectively); a centralized IGF-1 assay; pituitary MRI (Coronal

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Aleksandra Gilis-Januszewska Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland

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Łukasz Kluczyński Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland

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Alicja Hubalewska-Dydejczyk Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland

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. confirmed MRI changes of the hypothalamus/pituitary area in 93% patients who suffered from post-traumatic pituitary dysfunction ( 30 ). Fatal TBI cases were associated with pituitary infarction in up to 43% of autopsies ( 20 ). The hypothalamus is not

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