Bliss Anderson
Bliss Anderson
Department of Endocrinology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
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Introduction Immunotherapy with immune checkpoint inhibitors (CPI’s) has been revolutionising the management of advanced malignancies with their success in improving overall patient survival ( 1 , 2 ). CPI’s are antibodies that block T
Nikolaos Kyriakakis
Nikolaos Kyriakakis
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Marilena Giannoudi
Marilena Giannoudi
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Satish S Kumar
Satish S Kumar
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Khyatisha Seejore
Khyatisha Seejore
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Georgios K Dimitriadis
Georgios K Dimitriadis
Department of Endocrinology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
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Harpal Randeva
Harpal Randeva
Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
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Adam Glaser
Adam Glaser
Pediatric Oncology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute of Medical Research, University of Leeds, UK
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Leeds Institute of Medical Research, University of Leeds, UK
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Michelle Kwok-Williams
Michelle Kwok-Williams
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Georgina Gerrard
Georgina Gerrard
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Carmel Loughrey
Carmel Loughrey
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Ahmed Al-Qaissi
Ahmed Al-Qaissi
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Ramzi Ajjan
Ramzi Ajjan
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Julie Lynch
Julie Lynch
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Robert D Murray
Robert D Murray
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Introduction Malignant brain tumours affect both children and adults, although have markedly different long-term outcomes. Five-year survival rates of 73% have been reported following multi-modality treatment in children diagnosed with
G Giuffrida
G Giuffrida
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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F Ferraù
F Ferraù
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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R Laudicella
R Laudicella
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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O R Cotta
O R Cotta
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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E Messina
E Messina
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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F Granata
F Granata
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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F F Angileri
F F Angileri
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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A Vento
A Vento
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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A Alibrandi
A Alibrandi
Department of Economics, University of Messina, Messina, Sicily, Italy
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S Baldari
S Baldari
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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S Cannavò
S Cannavò
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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patients have been summarized in the study by Priola et al . ( 6 ). GBq, giga becquerel; NA, not available; PFS, progression-free survival (from PRRT); RT, radiotherapy; TMZ, temozolomide. Overall evaluation On the basis of our
Yukari Maki
Yukari Maki
Department of Pediatric Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan
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Kiyomi Horiuchi
Kiyomi Horiuchi
Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan
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Takahiro Okamoto
Takahiro Okamoto
Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan
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burden poses paramount importance for society and individuals. Most patients with PTC have a good prognosis, whereas a few may experience recurrence or even death ( 4 , 5 ). In addition to the oncologic events, subjective sequelae following diagnosis and
Marra Jai Aghajani
Marra Jai Aghajani
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Tara Laurine Roberts
Tara Laurine Roberts
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Tao Yang
Tao Yang
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Charles Eugenio McCafferty
Charles Eugenio McCafferty
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Nicole J Caixeiro
Nicole J Caixeiro
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia
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Paul DeSouza
Paul DeSouza
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Navin Niles
Navin Niles
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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/niceopdivoappraisal.pdf ) 14 Wang L Wang H Chen H Wang WD Chen XQ Geng QR Xia ZJ Lu Y . Serum levels of soluble programmed death ligand 1 predict treatment response and progression free survival in multiple myeloma . Oncotarget 2015 6 . ( https
Renea A Taylor
Renea A Taylor
Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia
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Jennifer Lo
Jennifer Lo
Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia
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Natasha Ascui
Natasha Ascui
Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia
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Matthew J Watt
Matthew J Watt
Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia
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, although the slow growing nature of prostate cancer means it often takes decades for this progression to become clinically relevant (3) . Being a slow growing cancer, the 5-year survival rate from prostate cancer is a very high (∼98.9% based on SEER 2005
Kunal Thakkar
Kunal Thakkar
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Swati Ramteke-Jadhav
Swati Ramteke-Jadhav
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Rajeev Kasaliwal
Rajeev Kasaliwal
Department of Endocrinology, Mahatma Gandhi Medical College & Hospital, Jaipur, India
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Saba Samad Memon
Saba Samad Memon
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Virendra Patil
Virendra Patil
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Puja Thadani
Puja Thadani
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Nilesh Lomte
Nilesh Lomte
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Shilpa Sankhe
Shilpa Sankhe
Department of Radiology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Atul Goel
Atul Goel
Department of Neurosurgery, Seth G S Medical College & KEM Hospital, Mumbai, India
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Sridhar Epari
Sridhar Epari
Department of Pathology, Tata Memorial Centre, Mumbai, India
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Naina Goel
Naina Goel
Department of Neuropathology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Anurag Lila
Anurag Lila
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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, was the most common complication seen in their series, while mean duration of disease free survival was 28 months on long-term follow-up. At 10 months of follow-up, our patient remains on hormone replacement therapy with no tumor residue. MPNST
Elizaveta Mamedova
Elizaveta Mamedova
Department of Neuroendocrinology and Bone Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Natalya Mokrysheva
Natalya Mokrysheva
Department of Parathyroid Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Evgeny Vasilyev
Evgeny Vasilyev
Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Center, Moscow, Russian Federation
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Vasily Petrov
Vasily Petrov
Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Center, Moscow, Russian Federation
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Ekaterina Pigarova
Ekaterina Pigarova
Department of Neuroendocrinology and Bone Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Sergey Kuznetsov
Sergey Kuznetsov
Department of Surgery, Endocrinology Research Center, Moscow, Russian Federation
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Nikolay Kuznetsov
Nikolay Kuznetsov
Department of Surgery, Endocrinology Research Center, Moscow, Russian Federation
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Liudmila Rozhinskaya
Liudmila Rozhinskaya
Department of Neuroendocrinology and Bone Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Galina Melnichenko
Galina Melnichenko
I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Institute of Clinical Endocrinology, Endocrinology Research Center, Moscow, Russian Federation
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Institute of Clinical Endocrinology, Endocrinology Research Center, Moscow, Russian Federation
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Ivan Dedov
Ivan Dedov
Endocrinology Research Center, Moscow, Russian Federation
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Anatoly Tiulpakov
Anatoly Tiulpakov
Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Center, Moscow, Russian Federation
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the abovementioned genes were as follows: NM_130799.2, NM_000388.3, NM_024529.4, NM_078467.2, NM_004064.4, NM_000076.2, NM_000077.4, NM_001262.2, NM_001800, respectively. ANNOVAR free software ( http://annovar.openbioinformatics.org ) was used for
Sofia S Pereira
Sofia S Pereira
Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Endocrine, Cardiovascular & Metabolic Research, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS/UP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Endocrine, Cardiovascular & Metabolic Research, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS/UP), Porto, Portugal
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Mariana P Monteiro
Mariana P Monteiro
Endocrine, Cardiovascular & Metabolic Research, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS/UP), Porto, Portugal
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Sonir R Antonini
Sonir R Antonini
Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil
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Duarte Pignatelli
Duarte Pignatelli
Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Hospital S. João, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Hospital S. João, Porto, Portugal
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found to be different in malignant when compared to benign ACT ( 24 ). Concerning prognostic differences in children with ACC, a low CASP3 expression was found to be associated with a lower 5-year event-free survival, while low levels of CASP9 were
Anello Marcello Poma
Anello Marcello Poma
Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
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Riccardo Giannini
Riccardo Giannini
Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
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Paolo Piaggi
Paolo Piaggi
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
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Clara Ugolini
Clara Ugolini
Department of Laboratory Medicine, Section of Pathology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
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Gabriele Materazzi
Gabriele Materazzi
Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
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Paolo Miccoli
Paolo Miccoli
Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Fulvio Basolo
Fulvio Basolo
Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
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FTC diagnosis in the presence of capsular invasion (even partial) without vascular involvement, since these tumors, although rarely, can develop recurrences and metastatic disease ( 14 , 15 ). Despite the unresolved issues in MI-FTC diagnosis, it has
