Sidsel Mathiesen
Sidsel Mathiesen
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Kaspar Sørensen
Kaspar Sørensen
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Marianne Ifversen
Marianne Ifversen
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Casper P Hagen
Casper P Hagen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Jørgen Holm Petersen
Jørgen Holm Petersen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Klaus Müller
Klaus Müller
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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of which some were prepubertal at last follow-up), the follow-up times were limited (median age at last follow-up 14–19 years), and importantly, none of the studies included semen quality data. Moreover, no previous studies have investigated pubertal
M Axelstad
M Axelstad
Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark
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U Hass
U Hass
Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark
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M Scholze
M Scholze
Brunel University, Uxbridge, UK
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S Christiansen
S Christiansen
Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark
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A Kortenkamp
A Kortenkamp
Brunel University, Uxbridge, UK
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J Boberg
J Boberg
Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark
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Introduction Human semen quality is declining in many parts of the world, and this has recently been confirmed by a comprehensive meta-analysis showing declining sperm counts in North America, Europe, Australia and New Zealand over the last
D Santi
D Santi
Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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A R M Granata
A R M Granata
Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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M Simoni
M Simoni
Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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Unit of Endocrinology, Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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ART (8) . The outcome of ICSI seems to be influenced by sperm structure and quality (9) . Thus, it seems reasonable that an improvement in sperm quality could effect ICSI outcomes. The empirical administration of follicle stimulating hormone (FSH) to
Soraya Puglisi
Soraya Puglisi
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Paola Perotti
Paola Perotti
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Mattia Barbot
Mattia Barbot
Endocrinology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy
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Paolo Cosio
Paolo Cosio
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Carla Scaroni
Carla Scaroni
Endocrinology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy
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Antonio Stigliano
Antonio Stigliano
Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital University of Rome, Rome, Italy
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Pina Lardo
Pina Lardo
Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital University of Rome, Rome, Italy
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Valentina Morelli
Valentina Morelli
Endocrinology Unit, Department of Clinical Sciences and Community Health, University of Milan and Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
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Elisa Polledri
Elisa Polledri
Department of Clinical Sciences and Community Health, Laboratory of Toxicology, University of Milan and Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy
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Iacopo Chiodini
Iacopo Chiodini
Endocrinology Unit, Department of Clinical Sciences and Community Health, University of Milan and Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
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Giuseppe Reimondo
Giuseppe Reimondo
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Anna Pia
Anna Pia
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Massimo Terzolo
Massimo Terzolo
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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(hypertension, coronary artery disease, heart failure, stroke, thromboembolic events), increased susceptibility to infections and mood disorders. Therefore, CS is characterized by impaired quality of life ( 1 ) and increased mortality, with a reported standard
Dorte Glintborg
Dorte Glintborg
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Magda Lambaa Altinok
Magda Lambaa Altinok
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Pernille Ravn
Pernille Ravn
Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
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Kurt Bjerregaard Stage
Kurt Bjerregaard Stage
Department of Psychiatry, Odense University Hospital, Odense, Denmark
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Kurt Højlund
Kurt Højlund
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Marianne Andersen
Marianne Andersen
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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obesity predicts the development of type 2 diabetes mellitus in PCOS ( 3 ). Furthermore, obesity predicted poor quality of life in women with PCOS ( 4 ), and the risk of depression was 2–5 times increased in PCOS ( 5 , 6 ). PCOS is characterized by
Guido Zavatta
Guido Zavatta
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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Bart L Clarke
Bart L Clarke
Mayo Clinic, Rochester, Minnesota, USA
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relatively increased bone density at the lumbar spine, stabilizes hip bone density, and reduces it at the wrist. Producing a PTH analog with finely balanced resorptive and anabolic properties is a significant challenge. Lastly, quality of life (QoL) is
Milou Cecilia Madsen
Milou Cecilia Madsen
Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Martin den Heijer
Martin den Heijer
Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Claudia Pees
Claudia Pees
Walaeus Library, Leiden University Medical Center, Leiden, the Netherlands
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Nienke R Biermasz
Nienke R Biermasz
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Leontine E H Bakker
Leontine E H Bakker
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
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concentrations in serum in the morning on at least two occasions (<10.4 nmol/L) ( 2 , 3 ). Low androgen levels cause morbidity and affect health-related quality of life (HR-QoL) due to infertility, decrease of sexual functions, muscle mass, strength and vitality
Amir H Zamanipoor Najafabadi
Amir H Zamanipoor Najafabadi
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands
Department of Neurosurgery, University Neurosurgical Centre Holland (UNCH), Leiden University Medical Centre, Haaglanden Medical Centre and Haga Teaching Hospitals, Leiden and The Hague, The Netherlands
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Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands
Department of Neurosurgery, University Neurosurgical Centre Holland (UNCH), Leiden University Medical Centre, Haaglanden Medical Centre and Haga Teaching Hospitals, Leiden and The Hague, The Netherlands
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Merel van der Meulen
Merel van der Meulen
Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands
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Ana Luisa Priego Zurita
Ana Luisa Priego Zurita
Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands
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S Faisal Ahmed
S Faisal Ahmed
Chair of Work Package of E-Health & ICT of Endo-ERN, Developmental Endocrinology Research Group, School of Medicine, Dentistry & Nursing, University of Glasgow and Office for Rare Conditions, Royal Hospital for Children & Queen Elizabeth University Hospital, Glasgow, UK
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Wouter R van Furth
Wouter R van Furth
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
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Evangelia Charmandari
Evangelia Charmandari
Pediatric Chair Main Thematic Group 6 Pituitary of Endo-ERN, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
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Olaf Hiort
Olaf Hiort
Pediatric Chair and Deputy Coordinator of Endo-ERN, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Lübeck, Lübeck, Germany
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Alberto M Pereira
Alberto M Pereira
Adult Chair and Coordinator of Endo-ERN, Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, The Netherlands
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Mehul Dattani
Mehul Dattani
London Centre for Pediatric Endocrinology and Diabetes at Great Ormond Street Children's Hospital and University College London Hospitals, London, UK
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Diana Vitali
Diana Vitali
SOD ITALIA (Italian Organization for Septo Optic Dysplasia and other Neuroendocrine Disorders), European Patient Advocacy Group, Rome, Italy
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Johan P de Graaf
Johan P de Graaf
Dutch Pituitary Foundation, European Patient Advocacy Group, Nijkerk, The Netherlands
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Nienke R Biermasz
Nienke R Biermasz
Adult Chair Main Thematic Group 6 Pituitary of Endo-ERN, Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands
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Introduction The European Reference Network on Rare Endocrine Conditions (Endo-ERN) aims to organize high-quality healthcare throughout Europe for patients with rare endocrine conditions. Through intensive collaboration between its reference
N Bergmann
N Bergmann
Endocrine Unit, The National Research Centre for the Working Environment, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, DK-2730 Herlev, Denmark
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F Gyntelberg
F Gyntelberg
Endocrine Unit, The National Research Centre for the Working Environment, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, DK-2730 Herlev, Denmark
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J Faber
J Faber
Endocrine Unit, The National Research Centre for the Working Environment, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, DK-2730 Herlev, Denmark
Endocrine Unit, The National Research Centre for the Working Environment, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, DK-2730 Herlev, Denmark
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Endocrine Unit, The National Research Centre for the Working Environment, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, DK-2730 Herlev, Denmark
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is a necessary defence mechanism in situations of acute stress. However, if stress persists a state designated allostatic-load or chronic stress is reached, which among other things results in distress, reduced quality of life, or depression (4
Stefan Riedl
Stefan Riedl
Division of Pediatric Pulmology, Allergology and Endocrinology, Department of Pediatrics, Medical University of Vienna, Vienna, Austria
Department of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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Department of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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Friedrich-Wilhelm Röhl
Friedrich-Wilhelm Röhl
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Germany
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Walter Bonfig
Walter Bonfig
Department of Pediatrics, Klinikum Wels-Grieskirchen, Wels, Austria
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Jürgen Brämswig
Jürgen Brämswig
Department of Pediatrics, Pediatric Endocrinology, Westfälische Wilhelmsuniversität Münster, Münster, Germany
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Annette Richter-Unruh
Annette Richter-Unruh
Department of Pediatrics, Pediatric Endocrinology, Westfälische Wilhelmsuniversität Münster, Münster, Germany
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Susanne Fricke-Otto
Susanne Fricke-Otto
Department of Pediatrics, Pediatric Endocrinology, Helios Klinikum Krefeld, Krefeld, Germany
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Markus Bettendorf
Markus Bettendorf
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany
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Felix Riepe
Felix Riepe
Pediatric Endocrinology, Kronshagen, Kiel, Germany
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Gernot Kriegshäuser
Gernot Kriegshäuser
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria
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Eckhard Schönau
Eckhard Schönau
Department of Pediatrics, Pediatric Endocrinology, Universität zu Köln, Cologne, Germany
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Gertrud Even
Gertrud Even
Department of Pediatrics, Pediatric Endocrinology, Universität zu Köln, Cologne, Germany
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Berthold Hauffa
Berthold Hauffa
Department of Pediatric Endocrinology, University of Duisburg-Essen, Essen, Germany
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Helmuth-Günther Dörr
Helmuth-Günther Dörr
Department of Pediatrics, Pediatric Endocrinology, Friedrich Alexander Universität Erlangen, Erlangen, Germany
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Reinhard W Holl
Reinhard W Holl
Institute of Epidemiology and Medical Biometry (ZIBMT), University of Ulm, Ulm, Germany
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Klaus Mohnike
Klaus Mohnike
Department of Pediatrics, Pediatric Endocrinology, Otto von Guericke Universität Magdeburg, Magdeburg, Germany
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the AQUAPE CAH Study Group
the AQUAPE CAH Study Group
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such data on screened CAH patients. Subjects and methods AQUAPE database The AQUAPE (Working Group on Quality Assurance in Pediatric Endocrinology) CAH is an initiative prospectively recording clinical follow-up data from patients with CAH
