Search for other papers by Peiwen Wu in
Google Scholar
PubMed
Search for other papers by Dongjie He in
Google Scholar
PubMed
Search for other papers by Hao Chang in
Google Scholar
PubMed
Search for other papers by Xiaozhi Zhang in
Google Scholar
PubMed
worse prognosis. This is consistent with the results of previous studies ( 1 , 13 , 44 ). Possible explanations for the poorer prognosis in men are that estrogen and progesterone receptor expression is associated with the prognosis of patients with
Search for other papers by Qiuli Liu in
Google Scholar
PubMed
Search for other papers by Lin-ang Wang in
Google Scholar
PubMed
Search for other papers by Jian Su in
Google Scholar
PubMed
Search for other papers by Dali Tong in
Google Scholar
PubMed
Search for other papers by Weihua Lan in
Google Scholar
PubMed
Search for other papers by Luofu Wang in
Google Scholar
PubMed
Search for other papers by Gaolei Liu in
Google Scholar
PubMed
Search for other papers by Jun Zhang in
Google Scholar
PubMed
AmCare Genomics Lab, Guangzhou, People’s Republic of China
Search for other papers by Victor Wei Zhang in
Google Scholar
PubMed
Search for other papers by Dianzheng Zhang in
Google Scholar
PubMed
Search for other papers by Rongrong Chen in
Google Scholar
PubMed
Search for other papers by Qingyi Zhu in
Google Scholar
PubMed
Search for other papers by Jun Jiang in
Google Scholar
PubMed
-hydroxylase, which catalyzes the 17α-hydroxylation of pregnenolone and progesterone and the 17,20-cleavage of the corresponding hydroxylated steroids ( 5 ). CYP17A1 deficiency leads to the impaired synthesis of both glucocorticoids and androgen, resulting in
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Search for other papers by Bledar Daka in
Google Scholar
PubMed
Search for other papers by Thord Rosen in
Google Scholar
PubMed
Search for other papers by Per Anders Jansson in
Google Scholar
PubMed
Search for other papers by Lennart Råstam in
Google Scholar
PubMed
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Search for other papers by Charlotte A Larsson in
Google Scholar
PubMed
Search for other papers by Ulf Lindblad in
Google Scholar
PubMed
as leisure time physical activity. Women on treatment with contraceptives and hormonal replacement therapy (progesterone alone, oestrogen alone or the combination) were excluded from analyses (remaining women=1002). Standard instruments were also used
Search for other papers by Jennifer K Y Ko in
Google Scholar
PubMed
Search for other papers by Thomas F J King in
Google Scholar
PubMed
Search for other papers by Louise Williams in
Google Scholar
PubMed
Search for other papers by Sarah M Creighton in
Google Scholar
PubMed
Search for other papers by Gerard S Conway in
Google Scholar
PubMed
use of testosterone, which in this situation is used as a prohormone providing oestradiol via aromatisation. As women with CAIS do not have a uterus, progesterone is not required. Based on our clinical experience, interest in the use of testosterone
Search for other papers by Lachlan Angus in
Google Scholar
PubMed
Search for other papers by Shalem Leemaqz in
Google Scholar
PubMed
Search for other papers by Olivia Ooi in
Google Scholar
PubMed
Search for other papers by Pauline Cundill in
Google Scholar
PubMed
Search for other papers by Nicholas Silberstein in
Google Scholar
PubMed
Search for other papers by Peter Locke in
Google Scholar
PubMed
Search for other papers by Jeffrey D Zajac in
Google Scholar
PubMed
Search for other papers by Ada S Cheung in
Google Scholar
PubMed
progesterone receptor which, similar to oestradiol treatment, causes further negative feedback to suppress GnRH and gonadotropins at the hypothalamus and pituitary respectively to lower testosterone production ( 16 , 17 ). As spironolactone may potentially
Search for other papers by Angelo Maria Patti in
Google Scholar
PubMed
Search for other papers by Kalliopi Pafili in
Google Scholar
PubMed
Search for other papers by Nikolaos Papanas in
Google Scholar
PubMed
Search for other papers by Manfredi Rizzo in
Google Scholar
PubMed
Introduction There are several pregnancy indices of hormonal changes (such as oestrogens, progesterone, corticotropin-releasing hormone, cortisol, human placental growth hormone and human placental lactogen) that are implicated in the
Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK
Search for other papers by Timothy J Morris in
Google Scholar
PubMed
Search for other papers by Andrew Whatmore in
Google Scholar
PubMed
Search for other papers by Laura Hamilton in
Google Scholar
PubMed
Search for other papers by Beverly Hird in
Google Scholar
PubMed
Search for other papers by Eric S Kilpatrick in
Google Scholar
PubMed
Search for other papers by Lesley Tetlow in
Google Scholar
PubMed
Search for other papers by Peter Clayton in
Google Scholar
PubMed
present for plasma sodium ( Table 3 ). Table 3 Correlations between renin MoU, electrolytes, 17α-OH-progesterone and fludrocortisone dose. Sodium Potassium 17α-OHP Fludrocortisone dose Post-clinic fludrocortisone dose
Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Sophie Howarth in
Google Scholar
PubMed
Search for other papers by Luca Giovanelli in
Google Scholar
PubMed
Search for other papers by Catherine Napier in
Google Scholar
PubMed
Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Simon H Pearce in
Google Scholar
PubMed
reference range (0 min = 309 nmol/L, 30 min = 323 nmol/L, 60 min = 344 nmol/L, on a progesterone only contraceptive pill), and hydrocortisone 15 mg daily in a split dose was started ( Table 1 ). However, she quickly developed ankle swelling which resolved
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Search for other papers by Dorte Glintborg in
Google Scholar
PubMed
Search for other papers by Katrine Hass Rubin in
Google Scholar
PubMed
Search for other papers by Mads Nybo in
Google Scholar
PubMed
Department of Medicine, Holbæk Hospital, Holbæk, Denmark
Search for other papers by Bo Abrahamsen in
Google Scholar
PubMed
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Search for other papers by Marianne Andersen in
Google Scholar
PubMed
-grade inflammation and unbalanced estrogen/progesterone secretion in PCOS could have adverse effects on autoimmune function ( 7 , 8 ). In accordance, women with PCOS had higher secretion of anti-thyroid, anti-nuclear (ANA), anti-ovarian, and anti-islet cell
Search for other papers by Robert I Menzies in
Google Scholar
PubMed
Search for other papers by Xin Zhao in
Google Scholar
PubMed
Search for other papers by Linda J Mullins in
Google Scholar
PubMed
Search for other papers by John J Mullins in
Google Scholar
PubMed
Search for other papers by Carolynn Cairns in
Google Scholar
PubMed
Search for other papers by Nicola Wrobel in
Google Scholar
PubMed
Search for other papers by Donald R Dunbar in
Google Scholar
PubMed
Search for other papers by Matthew A Bailey in
Google Scholar
PubMed
Search for other papers by Christopher J Kenyon in
Google Scholar
PubMed
cholesterol disposal and lipid biosynthesis form a separate larger cluster. It is notable that genes encoding enzymes that metabolise steroids were also affected. Akr1c18 , which encodes a progesterone 20α hydroxysteroid dehydrogenase enzyme was switched on