Tanaka Medical Clinic, Yoichi, Japan
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Institute for Clinical Research, NHO Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan
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Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo, Japan
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biomarker of glomerular damage ( 17 , 42 ). It has also been reported that exposure of kidney organ culture to TNFR1 or TNFR2 increases apoptosis mainly in tubules ( 43 ) and that individual knockout mouse models of TNFR1 or TNFR2 have a delay in the
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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methylation, which may induce changes in the gene expression that favor the development of many features of the diabetes phenotype and of end-organ complications ( 14 , 15 ). In a rat model of type 1 diabetes mellitus (T1DM), Williams and coworkers ( 16
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insulin, free T 3 , free T 4 and TSH concentrations were measured by using electrochemiluminescence assays (Modular E170, Roche). The homeostasis model assessment of insulin resistance index (HOMA_IR) was calculated as fasting insulin (μIU/ml) × fasting
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Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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affected by cancer and its treatment. We will describe the experimental models that can be used to assess somatic cell function and discuss studies that have attempted to preserve fertility in males, which may involve manipulation of the somatic cells in
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.1080/15548627.2015.1042195 ) 20 Patra KC Wang Q Bhaskar PT Miller L Wang Z Wheaton W Chandel N Laakso M Muller WJ Allen EL Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
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physiological supply of T3 reduced prostate tumor weight and epithelial PCNA levels in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. These effects could be directly related to both an increase in T3 and a reduction in T4 levels as a result
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Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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diabetes, the depressor arm has been found to exert a protective role ( 5 ). Ang(1–7) prevents systolic hypertension and attenuates kidney fibrosis in the type 1 diabetes mouse model ( 6 ). Long-term administration of Ang(1–7) prevents heart and lung
Grup de Mutagènesi, CIBER Epidemiología y Salud Pública, Servei de Medicina Nuclear, Unidad de Endocrinología, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain
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Grup de Mutagènesi, CIBER Epidemiología y Salud Pública, Servei de Medicina Nuclear, Unidad de Endocrinología, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain
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Grup de Mutagènesi, CIBER Epidemiología y Salud Pública, Servei de Medicina Nuclear, Unidad de Endocrinología, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain
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together with a study using mouse models with deleted Thra and Thrb genes support the tumour suppressor functions of the TR genes (20) . Three studies have reported the association of genetic variants in the THRA gene with thyroid cancer risk, but
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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common laboratory rodent models makes characterisation of these new genes much more difficult and loss-of-functional analysis almost impossible. We have therefore extended our understanding of HSD11B1L expression, and tissue and cell localisation by
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metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency . Endocrinology 2005 146 103 – 112 . ( doi:10.1210/en.2004-0744 ). * (These authors contributed equally to this work)