Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Biomedicine, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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are caused by an overactivity of IL-1 and that antagonism of the IL-1 pathway would lead to a reduction of copeptin levels. In this study, we report the results of two interventional trials investigating effects of IL-1 antagonism in obese individuals
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nervous activity. The effects of the trial on EI, biochemical parameters, expired gas data, HR, CVRR, dyspnea feeling and leg fatigue scores and central blood volume were assessed using Student’s paired t -test. In order to examine the effects of trials
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NIHR/Wellcome Trust Clinical Research Facility, Addenbrookes Hospital, Cambridge, UK
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NIHR/Wellcome Trust Clinical Research Facility, Addenbrookes Hospital, Cambridge, UK
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Introduction At first sight obesity may appear as a condition that is easy to treat by either decreasing energy intake and/or increasing the energy expenditure. In practice, long-term weight loss is very difficult to achieve. Since strategies
Non-Communicable Diseases Research Unit, South African Medical Council, Tygerberg, South Africa
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Non-Communicable Diseases Research Unit, South African Medical Council, Tygerberg, South Africa
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The Modern Pioneer Center and ArSMRM for MRI Training and Development, Tripoli, Libya
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Non-Communicable Diseases Research Unit, South African Medical Council, Tygerberg, South Africa
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), but how it relates to DI is unknown. In addition, the relative contribution of insulin clearance and insulin secretion to a high AIRg has only been reported in African–American children ( 5 ), but studies in black African adults with obesity and
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Medical Microbiology Department, College of Basic Medicine, Qingdao University, Qingdao, China
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Physiology Department, College of Basic Medicine, Qingdao University, Qingdao, China
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metabolism regulation. Ghrelin acts on its receptor GHSR, a G-protein-coupled receptor in diverse central and peripheral areas to exert multiple effects ( 7 ). In peripheral, circulatory ghrelin is primarily produced by X-A cells in stomach ( 8 ) and its main
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obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty . Peptides 2011 32 1781 – 1786 . ( https://doi.org/10.1016/j.peptides.2011.07.016 ) 19 Bianco SD A potential mechanism for the sexual
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Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands
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variables). Vascular ultrasound measurements Central systolic and diastolic blood pressure were assessed with the SphygmoCor (AtCor Medical, Sydney, Australia), which calculates aortic blood pressure from brachial pulse wave. Brachial and central
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Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, Melbourne, Victoria, Australia
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dramatic increase in obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) ( 2 ). Adherence is further challenging for those with obesity and T2DM suffering from defects in lipid oxidation capacity, musculoskeletal pain, and peripheral neuropathy
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK
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Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
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Department of Paediatric Endocrinology, Makarios Children's Hospital, Nicosia, Cyprus
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Sussex Community NHS Trust, Brighton, UK
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Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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The University of Dublin, Trinity College Dublin, Dublin, Republic of Ireland
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in children and adolescents (CA) with PWS are well described, with weight gain and hyperphagia leading to obesity later on in childhood if access to food is uncontrolled, with premature mortality primarily due to obesity-related complications in
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Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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regulator of calcium levels ( 23 ), is associated with central BP and its haemodynamic determinants in 622 normotensive or never-treated hypertensive subjects, who had plasma PTH and calcium concentrations predominantly within the normal range. Passive head