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Shatha Alharazy Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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M Denise Robertson Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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Susan Lanham-New Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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Muhammad Imran Naseer Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

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Adeel G Chaudhary Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Centre for Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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Eman Alissa Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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vitamin D deficiency in patients with acute myocardial infarction . American Journal of Cardiology 2011 107 1636 – 1638 . ( https://doi.org/10.1016/j.amjcard.2011.01.048 ) 52 Jorde R Grimnes G . Vitamin D and metabolic health with special reference

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Anna C van der Burgh Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

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Samer R Khan Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

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Sebastian J C M M Neggers Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands

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Ewout J Hoorn Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands

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Layal Chaker Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

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testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels . JAMA 2013 310 1829 – 1836 . ( https://doi.org/10.1001/jama.2013.280386 ) 57 Onasanya O Iyer G Lucas E Lin D Singh S Alexander GC

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Iben Rix Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Zealand Pharma A/S, Søborg, Denmark

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Marie L Johansen Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Asger Lund Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Malte P Suppli Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Elizaveta Chabanova Department of Radiology, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Gerrit van Hall Clinical Metabolomics Core Facility, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jens J Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Nicolai J Wewer Albrechtsen Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Caroline Kistorp Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark

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, stable treatment with glucose-lowering and antihypertensive therapy according to guidelines, a history of cardiovascular disease (defined as previous myocardial infarction, significant coronary stenosis, peripheral artery disease, and/or previous stroke

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Yuan Huang Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

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Yunyun Hu The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Bingshu Bao The Second People’s Hospital, Luqiao, Taizhou, Zhejiang, China

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, myocardial infarction, and stroke); (v) less than 18 years old; (vi) pregnancy (VFA was not measured in pregnant women); (vii) lack of complete survey weight. Ultimately, our study included 5309 people aged 18–59 years, representing a CVD-free US population

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Henrik Falhammar Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

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Hedi Claahsen-van der Grinten Department of Pediatric Endocrine Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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Nicole Reisch Medizinische Klinik and Poliklinik IV, Department of Endocrinology, University Hospital Munich, Munich, Germany

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Jolanta Slowikowska-Hilczer Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland

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Anna Nordenström Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
Department of Paediatric Endocrinology, Astrid Lindgren Children Hospital, Karolinska University Hospital, Stockholm, Sweden

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Robert Roehle Coordinating Center for Clinical Studies, Charité Universitätsmedizin, Berlin, Germany

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Claire Bouvattier Paris-Sud University, Orsay, France
Department of Pediatric Endocrinology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

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Baudewijntje P C Kreukels Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands

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Birgit Köhler Department of Paediatric Endocrinology and Diabetology, Charité Universitätsmedizin, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany

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on behalf of the dsd-LIFE group
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dissection, valvular heart disease, hypertension, thromboembolism, myocardial infarction and stroke ( 5 ). Even though TS had the highest frequency of cardiovascular disease in our study, the frequency was almost as high in the group of 45,X/46,XY followed by

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Fernando Aprile-Garcia Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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María Antunica-Noguerol Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Maia Ludmila Budziñski Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Ana C Liberman Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Eduardo Arzt Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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. ( doi:10.1159/000087104 ). 7 Ridker PM Hennekens CH Roitman-Johnson B Stampfer MJ Allen J . Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men . Lancet 1998 351 88 – 92

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Qiuyu Huang Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China

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Hanshen Chen Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China

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Fan Xu Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China

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Chao Liu Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

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Yafeng Wang Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China

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Weifeng Tang Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing University Medical School, Jiangsu Province, China

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Liangwan Chen Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China

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Weng Q Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population . Tohoku Journal of Experimental Medicine 2014 233 89 – 94 . ( https://doi.org/10.1620/tjem.233.89 ) 36 Huang S Lv Z Deng Q Li L

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V G Pluimakers Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands

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M van Waas Department of Paediatric Oncology/Haematology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands

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C W N Looman Department of Public Health, Erasmus MC, Rotterdam, The Netherlands

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M P de Maat Department of Haematology, Erasmus MC, Rotterdam, The Netherlands

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R de Jonge Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands

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P Delhanty Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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M Huisman Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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F U S Mattace-Raso Section Geriatric Medicine, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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M M van den Heuvel-Eibrink Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands

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S J C M M Neggers Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands
Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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Sanderson JE Hasani M Volkova E , et al . Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study . Lancet 2008 372 224 – 233 . ( https://doi.org/10.1016/S

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Qiu-ming Yao Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Bin Wang Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Xiao-fei An Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Jin-an Zhang Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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Liumei Ding Department of Clinical Laboratory, Jinshan Hospital of Fudan University, Shanghai, China

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Lindblad U. Low concentrations of serum testosterone predict acute myocardial infarction in men with type 2 diabetes mellitus . BMC Endocrine Disorders 2015 15 35 . ( https://doi.org/10.1186/s12902-015-0034-1 ) 26209521 10.1186/s12902

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Hui-qing Yuan Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Jia-xi Miao Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Jia-ping Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Su-xiang Zhu Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Feng Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Xiao-hua Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Chun-hua Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Chao Yu Department of Clinical Laboratory, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Dong-mei Zhang Medical Research Center, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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had the following conditions: (i) presence of diabetes-associated autoantibodies; (ii) previous malignancies; (iii) severe cardiovascular diseases, such as myocardial infarction; (iv) ischemic and hemorrhagic stroke; (v) chronic liver diseases, such as

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