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June Young Choi Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea

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Jin Wook Yi Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Jun Hyup Lee Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Ra-Yeong Song Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Hyeongwon Yu Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea

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Hyungju Kwon Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Young Jun Chai Department of Surgery, Seoul National University Boramae Hospital, Seoul, Korea

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Su-jin Kim Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Kyu Eun Lee Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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). Genomic data were also combined with patient-matched clinical data to correlate the molecular findings with clinical characteristics. Materials and methods Data preparation We downloaded TCGA thyroid cancer data, including clinical information

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Malgorzata Oczko-Wojciechowska Department of Genetic and Molecular Diagnostics of Cancer, M. Sklodowska-Curie Institute National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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Agnieszka Czarniecka Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie Institute National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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Tomasz Gawlik Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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Barbara Jarzab Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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Jolanta Krajewska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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Introduction Medullary thyroid cancer (MTC) is a rare, malignant neoplasm from the C-cell of the thyroid, which occurs in sporadic and hereditary forms. Hereditary MTC develops in the course of MEN2A and MEN2B syndromes due to germline

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Alexander Heinzel RWTH University Hospital Aachen, Department of Nuclear Medicine, Aachen, Germany

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Dirk Müller Institute for Health Economics and Clinical Epidemiology, University of Cologne, Cologne, Germany

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Hanneke M van Santen Wilhelmina Children’s Hospital, University Medical Center Utrecht, Department of Pediatric Endocrinology, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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Sarah C Clement Wilhelmina Children’s Hospital, University Medical Center Utrecht, Department of Pediatric Endocrinology, Utrecht, The Netherlands
Emma Children’s Hospital, Amsterdam UMC, Department of Pediatrics, Amsterdam, The Netherlands

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Arthur B Schneider University of Illinois at Chicago, Department of Medicine, Chicago, IL, USA

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Frederik A Verburg Erasmus MC Rotterdam, Department of Radiology & Nuclear Medicine, Rotterdam, The Netherlands
University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany

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Introduction Childhood cancer survivors (CCS) who received radiation therapy to the cervical region (cranial/ cranio-spinal or chest) are at increased risk of developing differentiated thyroid cancer (DTC) among other malignancies. Long

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Rocío del Carmen Bravo-Miana Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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Ana Belén Della Vedova Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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Ana Lucía De Paul Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Av. Enrique Barros y Enfermera Gordillo, Ciudad Universitaria, Córdoba, Argentina

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María Mónica Remedi Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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María Laura Guantay Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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Mónica Beatriz Gilardoni Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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Claudia Gabriela Pellizas Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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Ana Carolina Donadio Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica, Córdoba, Argentina
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina

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cancer is the most common malignancy of the endocrine system, with an increasing incidence rate recorded over the last three decades ( 18 ). The contribution of the tumor microenvironment to the development of thyroid cancer is beginning to be better

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Yuan Fang Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

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Xuehong Zhang Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

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Huilin Xu Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Stephanie A Smith-Warner Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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Dongli Xu Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Hong Fang Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Wang Hong Xu Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

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.18–1.50) and thyroid cancer (SIR: 1.55, 95% CI: 1.27–1.82). Table 2 Cancer incidence in patients with type 2 diabetes, Shanghai, China, 2002–2014. Men ( N  = 24,124) Women ( N  = 27,200) No. of cases Person-years CIR a (95% CI

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J Brossaud Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France
Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France

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V Pallet Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France

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J-B Corcuff Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France
Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France

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probably its potential therapeutic use in thyroid cancer. The rational for this interest is precisely the potential ability of RA isoforms to sustain cell differentiation or to reverse cell dedifferentiation in various models of cancer. With regards to a

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Ayanthi Wijewardene Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine, The University of Sydney, Sydney, Australia

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Matti Gild Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine, The University of Sydney, Sydney, Australia

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Lyndal Tacon Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine, The University of Sydney, Sydney, Australia

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Venessa Tsang Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine, The University of Sydney, Sydney, Australia

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Anthony J Gill Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, Sydney, Australia
Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney Australia

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Anthony Robert Glover Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Endocrine Surgery, Royal North Shore Hospital, Sydney, Australia

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Mark Sywak Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Endocrine Surgery, Royal North Shore Hospital, Sydney, Australia

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Stan Sidhu Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Endocrine Surgery, Royal North Shore Hospital, Sydney, Australia

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Bruce Robinson Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine, The University of Sydney, Sydney, Australia

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Paul Roach Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia

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Geoffrey Schembri Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia

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Jeremy Hoang Faculty of Medicine, The University of Sydney, Sydney, Australia
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia

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Roderick Clifton-Bligh Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine, The University of Sydney, Sydney, Australia

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Introduction Radioactive iodine (RAI) is frequently administered in the management of differentiated thyroid cancer (DTC) to reduce the risk of recurrence or treat persistent disease following a total thyroidectomy. The recommendations for RAI

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Camila Aparecida Moma Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Icléia Siqueira Barreto Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Ligia Vera Montali Assumpção Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Denise Engelbrecht Zantut-Wittmann Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Introduction Thyroid cancer is the most common endocrine neoplasm, corresponding to 3.4% of all malignant neoplasms diagnosed annually. About 90% are differentiated tumors derived from thyroid follicular cells ( 1 , 2 , 3 ). In recent

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Barbora Pekova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Sarka Dvorakova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Vlasta Sykorova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Gabriela Vacinova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Eliska Vaclavikova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Jitka Moravcova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Rami Katra Department of Ear, Nose and Throat, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Petr Vlcek Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Pavla Sykorova Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Daniela Kodetova Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Josef Vcelak Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Bela Bendlova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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malignancy is higher in pediatric nodules compared with adults, 26 vs 7–15% ( 2 , 4 ). Pediatric thyroid cancer is a rare disease occurring mostly in females than in males ( 1 ). The most common type is papillary thyroid cancer (PTC), which represents 90

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Changjiao Yan Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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Meiling Huang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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Xin Li Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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Ting Wang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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Rui Ling Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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Introduction Thyroid cancer, especially papillary subtype, is the most common malignancy in the endocrine system ( 1 ). Papillary thyroid cancer (PTC) can be further classified into conventional variant (CPTC), follicular variant (FVPTC) and

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