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). Genomic data were also combined with patient-matched clinical data to correlate the molecular findings with clinical characteristics. Materials and methods Data preparation We downloaded TCGA thyroid cancer data, including clinical information
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Introduction Medullary thyroid cancer (MTC) is a rare, malignant neoplasm from the C-cell of the thyroid, which occurs in sporadic and hereditary forms. Hereditary MTC develops in the course of MEN2A and MEN2B syndromes due to germline
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Emma Children’s Hospital, Amsterdam UMC, Department of Pediatrics, Amsterdam, The Netherlands
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University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany
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Introduction Childhood cancer survivors (CCS) who received radiation therapy to the cervical region (cranial/ cranio-spinal or chest) are at increased risk of developing differentiated thyroid cancer (DTC) among other malignancies. Long
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Av. Enrique Barros y Enfermera Gordillo, Ciudad Universitaria, Córdoba, Argentina
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Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba (X5000HUA), Argentina
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cancer is the most common malignancy of the endocrine system, with an increasing incidence rate recorded over the last three decades ( 18 ). The contribution of the tumor microenvironment to the development of thyroid cancer is beginning to be better
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Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
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.18–1.50) and thyroid cancer (SIR: 1.55, 95% CI: 1.27–1.82). Table 2 Cancer incidence in patients with type 2 diabetes, Shanghai, China, 2002–2014. Men ( N = 24,124) Women ( N = 27,200) No. of cases Person-years CIR a (95% CI
Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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probably its potential therapeutic use in thyroid cancer. The rational for this interest is precisely the potential ability of RA isoforms to sustain cell differentiation or to reverse cell dedifferentiation in various models of cancer. With regards to a
Faculty of Medicine, The University of Sydney, Sydney, Australia
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Faculty of Medicine, The University of Sydney, Sydney, Australia
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Faculty of Medicine, The University of Sydney, Sydney, Australia
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Faculty of Medicine, The University of Sydney, Sydney, Australia
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Department of Anatomical Pathology, NSW Health Pathology, Royal North Shore Hospital, Sydney, Australia
Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney Australia
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Department of Endocrine Surgery, Royal North Shore Hospital, Sydney, Australia
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Department of Endocrine Surgery, Royal North Shore Hospital, Sydney, Australia
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Department of Endocrine Surgery, Royal North Shore Hospital, Sydney, Australia
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Faculty of Medicine, The University of Sydney, Sydney, Australia
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Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia
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Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia
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Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia
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Faculty of Medicine, The University of Sydney, Sydney, Australia
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Introduction Radioactive iodine (RAI) is frequently administered in the management of differentiated thyroid cancer (DTC) to reduce the risk of recurrence or treat persistent disease following a total thyroidectomy. The recommendations for RAI
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Introduction Thyroid cancer is the most common endocrine neoplasm, corresponding to 3.4% of all malignant neoplasms diagnosed annually. About 90% are differentiated tumors derived from thyroid follicular cells ( 1 , 2 , 3 ). In recent
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malignancy is higher in pediatric nodules compared with adults, 26 vs 7–15% ( 2 , 4 ). Pediatric thyroid cancer is a rare disease occurring mostly in females than in males ( 1 ). The most common type is papillary thyroid cancer (PTC), which represents 90
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Introduction Thyroid cancer, especially papillary subtype, is the most common malignancy in the endocrine system ( 1 ). Papillary thyroid cancer (PTC) can be further classified into conventional variant (CPTC), follicular variant (FVPTC) and