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Maria Houborg Petersen Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Jacob Volmer Stidsen Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark

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Martin Eisemann de Almeida Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

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Emil Kleis Wentorf Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

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Kurt Jensen Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

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Niels Ørtenblad Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

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Kurt Højlund Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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effects of regular exercise training on insulin sensitivity, cardiorespiratory fitness, body composition, glycemic control, and lipid profile in patients with type 2 diabetes are well documented ( 3 , 4 ). Furthermore, there is evidence supporting a

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Shuqi Li Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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Chenye Shi Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Haifu Wu Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongmei Yan Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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Mingfeng Xia Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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Heng Jiao Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yang He Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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Ming Zhong Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenhui Lou Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xin Gao Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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Hua Bian Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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Xinxia Chang Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

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processes ( 53 ). As a key enzyme in glycolysis, LDH plays an important role in the regulation of glycometabolism. In db/db mice, OXA can improve glycemic control and insulin sensitivity via inhibition of tissue lactate production ( 54 ). In our study, OXA

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Bo Zhu Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Yumei Chen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Fang Xu Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Xiaolu Shen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Xuanyu Chen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Jieqiang Lv Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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Songying Zhang Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China

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insulin resistance and T2DM. For example, testosterone therapy improves β cell function and glycemic control in obese men who had secondary hypogonadism ( 36 ). In contrast, androgens excess predisposes women to insulin resistance and hyperglycemia. Female

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Rasha Odeh Section of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, University of Jordan, Amman, Jordan

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Abeer Alassaf Section of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, University of Jordan, Amman, Jordan

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Lubna Gharaibeh School of Pharmacy, University of Jordan, Amman, Jordan

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Sarah Ibrahim Section of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, University of Jordan, Amman, Jordan

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Fareed Khdair Ahmad Section of Pediatric Gastroenterology, Department of Pediatrics, School of Medicine, University of Jordan, Amman, Jordan

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Kamel Ajlouni The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), University of Jordan, Amman, Jordan

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deterioration in glycemic control or hypoglycemia should alert the health care professional to investigate and exclude CD. However, many pediatric T1D patients have asymptomatic CD and the diagnosis was made as a result of CD antibody screening ( 15 , 16 ) as

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E N Dudinskaya
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O N Tkacheva
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M V Shestakova National Research Center for Preventive Medicine, Endocrinology Research Centre, Building 10, Petroverigskiy Lane, Moscow 101990, Russian Federation

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N V Brailova
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I D Strazhesko
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D U Akasheva
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O Y Isaykina
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N V Sharashkina
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D A Kashtanova
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S A Boytsov
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. Influence of duration of diabetes, glycemic control, and traditional cardiovascular risk factors on early atherosclerotic vascular changes in adolescents and young adults with T2DM . Journal of Clinical Endocrinology and Metabolism 2009 94 3740 – 3745

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Jing Hong Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Wen-Yue Liu Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Xiang Hu Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Fei-Fei Jiang Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Ze-Ru Xu Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Fang Li Department of Endocrinology, Ruian Traditional Chinese Medicine Hospital, Wenzhou, China

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Fei-Xia Shen Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Hong Zhu Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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have also indicated that QTc is associated with age ( 30 ), glycemic control ( 31 ), hypertension ( 8 ), hyperuricemia ( 32 ), hyperinsulinemia ( 33 ), and metabolic syndrome ( 34 ), which are the risk factors for the occurrence of PAD in patients with

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Shufei Zang Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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Lei Shi Department of Neurology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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Jinying Zhao Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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Min Yang Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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Jun Liu Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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Heyuan Ding Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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, Impact of glycemic control strategies on the progression of diabetic peripheral neuropathy in the bypass angioplasty revascularization investigation 2 diabetes (bari 2D) cohort . Diabetes Care 2013 36 3208 – 3215 . ( https://doi.org/10.2337/dc13

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Marie Auzanneau Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Alexander J Eckert Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Andreas Fritsche German Center for Diabetes Research (DZD), Neuherberg, Germany
Department of Internal Medicine IV, University Hospital Tübingen, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany

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Martin Heni Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
Division of Endocrinology and Diabetology, Department of Internal Medicine 1, University Hospital Ulm, Ulm, Germany
Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany

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Andrea Icks German Center for Diabetes Research (DZD), Neuherberg, Germany
Institute of Health Services Research and Health Economics, Center for Health and Society, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Institute of Health Services Research and Health Economics, German Diabetes Center (DDZ), Leibniz Centre for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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Annabel S Mueller-Stierlin Department of General Practice and Primary Care, University Hospital Ulm, Um, Germany
Department of Psychiatry and Psychotherapy II, University Hospital Ulm, Um, Germany

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Ana Dugic Department of Gastroenterology, Klinikum Bayreuth, Medizincampus Oberfranken der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Bayreuth, Germany

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Alexander Risse Diabetes Center at Sophie-Charlotte-Platz, Diabetes Foot Unit, Berlin, Germany

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Stefanie Lanzinger Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Reinhard W Holl Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control . Diabetes Care 2009 32 1119 – 1131 . ( https://doi.org/10.2337/dc09-9029 ) 7 Fritsche A . Diabetes mellitus in der Klinik: mehr Strukturen schaffen

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Liangming Li Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Yuan Wei Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Chunlu Fang Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Shujing Liu Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Fu Zhou Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Ge Zhao Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Yaping Li Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Yuan Luo Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Ziyi Guo Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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Weiqun Lin Department of Clinical Nutrition, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China

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Wenqi Yang Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China

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effectiveness of exercise for T2DM treatment. Exercise improves glycemic control, reducing insulin resistance in patients with T2DM ( 18 ). Adipose tissue fibrosis, which is implicated as a contributor to insulin resistance, has been demonstrated to be prevented

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Khaled Kabarra Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia, USA

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Pegah Golabi Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA

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Zobair M Younossi Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia, USA
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA
Inova Medicine, Inova Health System, Falls Church, Virginia, USA

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). Liraglutide, a glucagon-like peptide 1 receptor agonist used for glycemic control in T2DM patients, has also shown in phase 2 clinical trials to reduce NASH with improvement in steatosis and hepatocyte ballooning ( 58 ). As stated above, these medications are

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