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with pituitary diseases were offered cryopreservation of semen for future fertility treatment before testosterone therapy was initiated, or in selected younger cases before pituitary surgery or radiation therapy. All patients who started testosterone
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expected stature, obesity, metabolic syndrome and infertility ( 1 , 2 , 4 ). Fertility problems in adult male patients with CAH have been attributed to the development of testicular adrenal rest tumors (TARTs) ( 3 , 4 , 5 ). The migration of adrenal
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Center for Healthy Aging, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany
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of UK Biobank cohort cases and controls is expected to shed some light on these complex interrelations. Several original research papers may complement this special series and deal with vitamin D deficiency in relation to male and female fertility
Alfred Health, Melbourne, Victoria, Australia
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Department of General Practice, Melbourne Medical School, The University of Melbourne, Victoria, Australia
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potentially anabolic–androgenic steroids also regulate this system to govern fertility. The suppression of gonadotropins is dose dependent and is also dependent on the type of androgen used. In other words, the feedback inhibition of androgens is not
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Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China
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ethnic groups ( 2 ). Obesity can reduce the quality of life of PCOS patients by contributing to irregular menstruation, oligo/anovulation, negative effects on self-esteem and self-image ( 3 , 4 ), and delayed fertility and infertility ( 5 ). Therefore
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New Children’s Hospital, Pediatric Research Center, Helsinki University Hospital, Helsinki, Finland
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). Moreover, miR-200 miRNAs are expressed in the GnRH neurons and pituitary, and they play a role in reproduction and fertility in mice ( 21 , 22 ). Lack of miR-200 members recapitulated KS phenotypes in zebrafish ( 6 ). As previous studies strongly indicate
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.1210/jcem.84.4.5591 ) 12 Teede HJ Meyer C Hutchison SK Zoungas S McGrath BP Moran LJ Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy . Fertility and Sterility 2010 93 184 – 191
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Janssen OE Legro RS Norman RJ Taylor AE . The androgen excess and PCOS society criteria for the polycystic ovary syndrome: the complete task force report. Fertility and Sterility 2009 91 456 – 488 . ( doi:10.1016/j.fertnstert.2008
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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medicine prescriptions (antidiabetics, oral contraceptives (OCP) and fertility treatment) were extracted from the National Prescription Registry. The women should have at least two or more dispenses of the medicine before index date. Diagnoses of obesity
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female fertility still remains unknown. Positive vaginal fluid after infection has been reported in few cases only ( 118 ), while other ones failed to detect the virus in the vaginal fluid ( 119 , 120 ). Larger studies indicate that intrapartum vaginal