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cells were treated with increasing concentration of MPP + for 24 h. (B, D and F) Cells were pretreated with IGF-1 (10 nM) for 1 h and then cells were exposed to 1 mM MPP + for 24 h. (A and B) Cell viability measured by the MTT assay. (C and D) LDH
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Vita-Salute San Raffaele University, Milan, Italy
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/L))) ( 27 ). AUC for insulin, C-peptide and BG during the OGTT (2 and 3 h) were calculated applying the trapezium rule. Insulin secretion and beta cell function Basal insulin secretion was assessed by the homeostatic model assessment b-cell function
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placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy . Endocrinology 1993 132 879 – 887
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infiltrated with macrophages, neutrophils, T- and B-cells, and mast cells during the development of obesity (34) . In this regard, adipose tissue from obese mice and humans is infiltrated and accumulated with a large number of macrophages, which can
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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energy metabolism ( 91 , 92 ). Visfatin is also involved in inflammatory responses (secretion of IL1β, IL6, and TNFα), prevention of neutrophils apoptosis, and maturation of B cells ( 93 , 94 ). Moreover, recent studies have shown that visfatin could
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State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, Hunan, People’s Republic of China
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Regulation of caMC3R expression and signaling by caMRAP2a or caMRAP2b. Cell surface expression (A) and total expression (B) of caMC3R modulated by caMRAP2a or caMRAP2b were measured by flow cytometry. Basal (C) and maximal signaling (D) of caMC3R regulated by
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and activator of transcription 5 (STAT5), Janus kinase 2 (JAK2), suppressors of cytokine signaling (SOCS1, SOCS2, CIS), hepatocyte nuclear factor 6 (HNF6) and B-cell lymphoma 6 (Bcl6); factors potentially involved in GH imprinting of CYP expression
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the alteration of B-cell physiology in aging . Gerontology 2019 66 1 – 9 . 8 Deuschle M Gotthardt U Schweiger U Weber B Korner A Schmider J Standhardt H Lammers CH Heuser I . With aging in humans the activity of the