Marra Jai Aghajani
Marra Jai Aghajani
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Tara Laurine Roberts
Tara Laurine Roberts
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Tao Yang
Tao Yang
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Charles Eugenio McCafferty
Charles Eugenio McCafferty
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Nicole J Caixeiro
Nicole J Caixeiro
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia
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Paul DeSouza
Paul DeSouza
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Navin Niles
Navin Niles
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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serum thyroglobulin (Tg) during TSH suppression (Tg <0.2 ng/mL) or following stimulation (Tg <1 ng/mL) with negative thyroglobulin antibodies. The patients that did not experience tumour persistence were censored at the last follow-up contact
Xi Cao
Xi Cao
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Ming Lu
Ming Lu
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Rong-Rong Xie
Rong-Rong Xie
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Li-Ni Song
Li-Ni Song
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Wei-Li Yang
Wei-Li Yang
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Zhong Xin
Zhong Xin
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Guang-Ran Yang
Guang-Ran Yang
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Jin-Kui Yang
Jin-Kui Yang
Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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population ( 6 ). Subclinical hypothyroidism (SCH), which is characterized by elevated thyroid-stimulating hormone (TSH), has attracted increasing attention, as it interacts with many metabolic diseases ( 7 , 8 ). Thyroid hormones, including TSH, have been
Guoquan Zhu
Guoquan Zhu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Yuying Deng
Yuying Deng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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carcinoma were selected in this retrospective study. All patients had undergone total or near-total thyroidectomy, RAI therapy and suppressive therapy with thyroid-stimulating hormone (TSH) at the Zhujiang Hospital of Southern Medical University (Guangzhou
Marek Niedziela
Marek Niedziela
Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland
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common cause being their excessive tissue concentration. Graves’ disease (GD) is a form of autoimmune hyperthyroidism associated with the presence of autoantibodies stimulating the thyroid-stimulating hormone (TSH) receptor (TRAb). Epidemiology GD
Kusum Lata
Kusum Lata
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Pinaki Dutta
Pinaki Dutta
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Subbiah Sridhar
Subbiah Sridhar
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Minakshi Rohilla
Minakshi Rohilla
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Anand Srinivasan
Anand Srinivasan
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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G R V Prashad
G R V Prashad
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Viral N Shah
Viral N Shah
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Anil Bhansali
Anil Bhansali
Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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expected, the mean TSH in the TPOAb + group was higher (3.1±1.9) compared with that of the TPOAb − group (2.0±1.0). The early evaluation of human thyrocyte TSH receptor stimulating immunoglobulin bioassays with the sera of Graves' disease, Hashimoto
Zhengrong Jiang
Zhengrong Jiang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Linghong Huang
Linghong Huang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Lijun Chen
Lijun Chen
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Jingxiong Zhou
Jingxiong Zhou
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Bo Liang
Bo Liang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Xuefeng Bai
Xuefeng Bai
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Lizhen Wu
Lizhen Wu
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Huibin Huang
Huibin Huang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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included the following ( 13 ): diffuse goitre, with symptoms of increased sweating, heat intolerance, elevated heart rate, elevated serum thyrotropin receptor antibody (TRAb), and low serum thyroid-stimulating hormone (TSH). The newly diagnosed GD patients
Marra Jai Aghajani
Marra Jai Aghajani
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Tao Yang
Tao Yang
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Ulf Schmitz
Ulf Schmitz
Computational BioMedicine Laboratory Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Gene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Faculty of Medicine & Health, The University of Sydney, Camperdown, New South Wales, Australia
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Gene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Faculty of Medicine & Health, The University of Sydney, Camperdown, New South Wales, Australia
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Alexander James
Alexander James
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
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Charles Eugenio McCafferty
Charles Eugenio McCafferty
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Paul de Souza
Paul de Souza
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
School of Medicine, University of Wollongong, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
School of Medicine, University of Wollongong, New South Wales, Australia
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Navin Niles
Navin Niles
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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Tara L Roberts
Tara L Roberts
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Association (ATA) Management Guidelines ( 25 ). An excellent response (absence of persistent tumour) following initial therapy was defined as negative imaging and either a low serum thyroglobulin (Tg) during thyroid stimulating hormone (TSH) suppression (Tg
Bliss Anderson
Bliss Anderson
Department of Endocrinology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
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). Prior use of a tyrosine kinase inhibitor also increases the risk of thyroid dysfunction ( 46 ). Raised levels of cytokines including IL-1β and IL-2 pre-treatment, as well as an early rise in thyroglobulin have been reported to predict thyroiditis ( 47
Lauren E Henke
Lauren E Henke
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA
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John D Pfeifer
John D Pfeifer
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA
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Thomas J Baranski
Thomas J Baranski
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA
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Todd DeWees
Todd DeWees
Division of Biomedical Statistics and Informatics, Mayo Clinic, Scottsdale, Arizona, USA
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Perry W Grigsby
Perry W Grigsby
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA
Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
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Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
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consisted of physical examination and laboratory studies, including thyroid-stimulating hormone (TSH), triiodothyronine and free thyroxine for all patients, with the addition of thyroglobulin levels in the latter years of the study. Table 1 Patient
Yun Cai
Yun Cai
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Jieni Yan
Jieni Yan
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yong Gu
Yong Gu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Heng Chen
Heng Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yang Chen
Yang Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Xinyu Xu
Xinyu Xu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Mei Zhang
Mei Zhang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Liping Yu
Liping Yu
Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA
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Xuqin Zheng
Xuqin Zheng
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Tao Yang
Tao Yang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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of the presence of circulating autoantibodies such as thyrotropin receptor autoantibodies (TRAb), thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TGAb). TRAb occurs predominantly in GD and plays a key role in Graves
