Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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, but the 17, 20 lyase activity is minimal in humans ( 6 ). The 17-hydroxylase induces rapid conversion of substrate pregnenolone (PE) and progesterone (P4) into intermediate precursors 17-hydroxypregnenolone (17-OHPE) and 17 - hydroxyprogesterone (17
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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. Steroid receptors are members of the nuclear receptor (NR) superfamily. They can be grouped into four classes according to their ligand-binding, DNA-binding, and dimerization properties: steroid receptors – progesterone receptor (PR), androgen receptor (AR
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and/or carriers of benign tumors from January 2012 to April 2014 underwent biopsy and breast cancer surgery. Breast cancer was confirmed by biopsy reports as well as pathologically by molecular tests including estrogen receptor (ER), progesterone
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.2–406.8) 17-OH-progesterone (nmol/L) / / 35.1 (4.0–102.2) Androstenedione (nmol/L) / / 9.6 (1.7–17.5) sFC (pg/mL) 29.5 (19.5–47.6) 25.6 (14.5–62.2) 29.9 (23.1–40.6) uFC (pg/mL) 127 (49.9–249.5) 190.5 (50.2–273.7) 95
Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
National Institute for Health Research (NIHR) Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK
Mohn Centre for Children’s Health and Wellbeing, Imperial College London, London, UK
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
National Institute for Health Research (NIHR) Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK
Mohn Centre for Children’s Health and Wellbeing, Imperial College London, London, UK
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://doi.org/10.1016/j.jchromb.2008.10.051 ) 9 de Groot MJ Pijnenburg-Kleizen KJ Thomas CM Sweep FC Stikkelbroeck NM Otten BJ & Claahsen-van der Grinten HL . Salivary morning androstenedione and 17α-OH progesterone levels in childhood and
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hormone (LH), follicle-stimulating hormone (FSH), testosterone (T) and dihydrotestosterone (DHT), androstenedione (A) and unstimulated and/or stimulated 17-hydroxy progesterone 17(OH) P levels (where indicated). Congenital adrenal hyperplasia was diagnosed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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estradiol and progesterone . Metabolism 1987 36 151 – 154 . ( doi:10.1016/0026-0495(87)90009-6 ). 22 Duarte B Hargis GK Kukreja SC . Effects of estradiol and progesterone on parathyroid hormone secretion from human parathyroid tissue . Journal
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fludrocortisone (0.05–0.2 mg divided in 3 doses per day) was given orally prior to puberty. Therapy was titrated aiming to achieve a 17-OH progesterone (17-OHP) level below 10 ng/mL. Follow-ups were scheduled at 4-month intervals and included measurement of the
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, we used the sequentially combined regimens with oestradiol valerate 0.5–2 mg or conjugated oestrogens 0.3–1.25 mg and adequate progesterone. The ultrasonography results were recorded annually. Data collection was performed independently by the first
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several limitations. It is a major limitation that we do not have the exact time for the last intake of steroids. For some of the hormones (especially 17OH-progesterone), the ICC 95% CI are quite broad covering relevant differences (from moderate to good