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Raymond J Rodgers, Jodie C Avery, Vivienne M Moore, Michael J Davies, Ricardo Azziz, Elisabet Stener-Victorin, Lisa J Moran, Sarah A Robertson, Nigel K Stepto, Robert J Norman and Helena J Teede

, central adiposity), reproductive dysfunction (infertility, menstrual irregularity, miscarriage, pregnancy complications) and metabolic complications ( 6 , 7 ). Metabolic features include insulin resistance (IR), compensatory hyperinsulinaemia and

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Min Li, Ying Chen, Jingjing Jiang, Yan Lu, Zhiyi Song, Shengjie Zhang, Chao Sun, Hao Ying, Xiaofang Fan, Yuping Song, Jialin Yang and Lin Zhao

adipokine profile ( 17 , 18 ). In contrast, mice depleted of Nrg4 or ErbB4 developed metabolic disorders as shown by development of obesity, dyslipidemia, hepatic steatosis, hyperglycemia, hyperinsulinemia and insulin resistance ( 14 , 19 ). Considering

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Lilit Egshatyan, Daria Kashtanova, Anna Popenko, Olga Tkacheva, Alexander Tyakht, Dmitry Alexeev, Natalia Karamnova, Elena Kostryukova, Vladislav Babenko, Maria Vakhitova and Sergey Boytsov

formula: (concentration of fasting blood glucose (mmol/l))×(concentration of fasting blood insulin (mU/l))/22.5. Insulin resistance (IR) was diagnosed if HOMA-IR >2.5 (11) . A 75 g OGTT was performed with blood glucose measurement before glucose intake

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Doron Weinstein, Rive Sarfstein, Zvi Laron and Haim Werner

are effectively used in clinical settings (2, 4) . The insulin-like growth factor (IGF) system has an important role in the normal growth and development of the prostate gland (5) . In addition to its physiological role, epidemiological, clinical

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Stavroula A Paschou, Nektaria Papadopoulou-Marketou, George P Chrousos and Christina Kanaka-Gantenbein

information on the pathogenesis of T1DM. We will present genetic, environmental and immunologic factors ( Table 1 ) that eventually destroy β cells of the endocrine pancreas and lead to insulin deficiency. Table 1 Contributing factors in type 1 diabetes

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Xiaolei Hu and Fengling Chen

). It was first reported by Berson and coworkers ( 2 ) that clinical hypersensitivity and insulin resistance were associated with circulating insulin antibodies (IAs) in patients receiving exogenous animal insulin therapy. Over the past few decades, with

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B Fabre, G Maccallini, A Oneto, D Gonzalez, V Hirschler, C Aranda and G Berg

/ml, the use of this assay would be unuseful in OGTT or postprandial settings. Although fasting serum insulin itself remains controversial as an indicator of insulin resistance, indices based on both fasting glucose and insulin (e.g. HOMA and QUICKI) may

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Yusaku Mori, Eunhyoung Ko, Rudolf Furrer, Linda C Qu, Stuart C Wiber, I George Fantus, Mario Thevis, Alan Medline and Adria Giacca

-known metabolic actions ( 1 ). Epidemiological studies showed that, in patients with type 2 diabetes and obese people with insulin resistance, endogenous hyperinsulinaemia is associated with increased risk for several types of cancer including breast cancer ( 2

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Tao Yuan, Lanping Jiang, Chen Chen, Xiaoyan Peng, Min Nie, Xuemei Li, Xiaoping Xing, Xuewang Li and Limeng Chen

sensitivity: (1) the OGTT insulin sensitivity index of Matsuda and DeFronzo (IS OGTT ) ( 8 ); (2) the quantitative insulin sensitivity check index (QUICKI) model and (3) the homeostasis model of assessment for insulin resistance (HOMA-IR). The IS OGTT model

Open access

Giorgio Bedogni, Andrea Mari, Alessandra De Col, Sofia Tamini, Amalia Gastaldelli and Alessandro Sartorio

Introduction The prevalence of childhood type 2 diabetes mellitus (T2DM) is rapidly increasing worldwide ( 1 ). T2DM is characterized by visceral obesity, insulin resistance and defective β-cell function. In children and adolescents, glucose