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Introduction The short stature homeobox-containing (SHOX) gene, located in pseudo-autosomal region 1 of the short arms of the X and Y chromosomes, encodes a homeodomain transcription factor involved in the regulation of longitudinal growth and
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testicular growth is in line with the assumption of an altered T action by UGT2B17 affecting pubarche, a testosterone-dependent event, but not testicular enlargement, which is a gonadotropin-dependent event ( 19 ). Further, our findings of an association of
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Weel-Sipman MH Vossen JM Wit JM . Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies . European Journal of Pediatrics 2000 159 31 – 37 . ( https://doi.org/10.1007/s
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.10.026 ) 6 Xie C Zhao Y Gao L Chen J Cai D Zhang Y . Elevated phthalates’ exposure in children with constitutional delay of growth and puberty . Molecular and Cellular Endocrinology 2015 407 67 – 73 . ( https://doi.org/10.1016/j.mce.2015
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://doi.org/10.2337/dbib8-1618 ) 10.2337/dc08-1618 19196890 18 Bisgaard A Sørensen K Johannsen TH Helge JW Andersson AM Juul A. Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents . International
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%) did not need adult endocrine follow-up because paediatric endocrine care was only puberty- or growth-related. Of the 226 patients who had an indication for adult follow-up, 46 did not enter regular transition because they participated in a pilot to
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; Y, yes. Other endocrine manifestations of SPLIS Given the high early childhood mortality associated with SPLIS, limited long-term growth data are available. There is no clear evidence of intrauterine growth retardation, with birthweight
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adoption of continuous hormone references using the well-established ‘LMS’ growth curve algorithm provides a clinically useful framework to standardize age- and sex-dependent variance and obtain standard deviation scores (SDS) ( 4 , 7 , 8 , 9 ). Briefly
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2006 Consensus Statement ( 4 ) were included in this study. The patients were identified via a database of patients with DSD followed at the Department of Growth and Reproduction, Copenhagen University Hospital, between January 1, 1996 and October 30
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ligand superfamily member 5 (CD40 ligand/TNFSF5); fractalkine (CX3CL1); growth regulated oncogene-α (CXCL1/GROA/KC/CINC-1); GROB (CXCL2/MIP2/CINC3); interferon-inducible protein 10 (CXCL10/IP10/CRG2); EGF; fibroblast growth factor (FGF basic/FGF2/bFGF