Lianghui You
Lianghui You
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Yan Wang
Yan Wang
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Yao Gao
Yao Gao
Department of Endocrinology, Children’s Hospital of Nanjing Medical University, Nanjing, China
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Xingyun Wang
Xingyun Wang
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
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Xianwei Cui
Xianwei Cui
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
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Yanyan Zhang
Yanyan Zhang
Beijing Chaoyang Distirct Maternal and Child Health Care Hospital, Beijing, China
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Lingxia Pang
Lingxia Pang
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
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Chenbo Ji
Chenbo Ji
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Xirong Guo
Xirong Guo
Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xia Chi
Xia Chi
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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demonstrated that the activation of thermogenesis in fat could produce a healthier metabolic phenotype with traits such as whole-body energy metabolism, improved glucose homeostasis, and weight loss ( 2 , 3 ). Moreover, functional BAT was discovered in adult
Jiayang Lin
Jiayang Lin
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Peizhen Zhang
Peizhen Zhang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Yan Huang
Yan Huang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Xueyun Wei
Xueyun Wei
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Dan Guo
Dan Guo
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Jianfang Liu
Jianfang Liu
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Deying Liu
Deying Liu
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Yajuan Deng
Yajuan Deng
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Bingyan Xu
Bingyan Xu
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Chensihan Huang
Chensihan Huang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Xiaoyu Yang
Xiaoyu Yang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Yan Lu
Yan Lu
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China
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Lijing Jia
Lijing Jia
Department of Endocrinology, Shenzhen People’s Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China
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Huijie Zhang
Huijie Zhang
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
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4 (Nrg4) ( 10 , 11 , 12 ), suggesting these hepatokines may be involved in the thyroid hormone signaling network to modulate energy homeostasis and lipid metabolism. These observations underscore the importance of hepatokines in cross-talk with
Helle Keinicke
Helle Keinicke
Insulin and Device Trial Operations, Novo Nordisk A/S, Søborg, Denmark
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Gao Sun
Gao Sun
Pharmacology and Histopathology, Novo Nordisk A/S, China
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Caroline M Junker Mentzel
Caroline M Junker Mentzel
Department of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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Merete Fredholm
Merete Fredholm
Department of Veterinary Clinical and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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Linu Mary John
Linu Mary John
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Birgitte Andersen
Birgitte Andersen
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Kirsten Raun
Kirsten Raun
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Marina Kjaergaard
Marina Kjaergaard
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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by directing glucose away from the liver toward BAT for heat production and increased energy expenditure. Genes involved in hepatic lipid metabolism were also highly regulated by FGF21 compared to mice shifted to chow diet. The expression pattern
Yang Yu
Yang Yu
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Hairong Hao
Hairong Hao
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Linghui Kong
Linghui Kong
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Jie Zhang
Jie Zhang
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Feng Bai
Feng Bai
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Fei Guo
Fei Guo
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Pan Wei
Pan Wei
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Rui Chen
Rui Chen
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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Wen Hu
Wen Hu
Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, Jiangsu, China
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, maintaining cholesterol homeostasis, inducing bile flow, excreting toxic substances and regulating energy metabolism ( 43 ). Recent advances in basic research have identified bile acids as nutrient sensors and metabolic integrators that activate farnesoid X
Selina Mäkinen
Selina Mäkinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Yen H Nguyen
Yen H Nguyen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Paulina Skrobuk
Paulina Skrobuk
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Heikki A Koistinen
Heikki A Koistinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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h ( Fig. 2C ). Glucose metabolism Glucose uptake To analyse if the observed changes in signalling events are reflected at glucose metabolism, human primary myotubes were pre-exposed to palmitate, oleate or their combination for 12 h
Wenqi Yang
Wenqi Yang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Ling Liu
Ling Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yuan Wei
Yuan Wei
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Chunlu Fang
Chunlu Fang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Fu Zhou
Fu Zhou
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Jinbao Chen
Jinbao Chen
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qinghua Han
Qinghua Han
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Meifang Huang
Meifang Huang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xuan Tan
Xuan Tan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiuyue Liu
Qiuyue Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiang Pan
Qiang Pan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Lu Zhang
Lu Zhang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xiaojuan Lei
Xiaojuan Lei
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Liangming Li
Liangming Li
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Kusminski CM Bauer SM Wade M Singhal E Cheng CC , An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice . Cell Metabolism 2013 17 790 – 797 . ( https://doi.org/10.1016/j.cmet.2013.03.019 ) 23663742 10.1016/j
Katrine M Lauritsen
Katrine M Lauritsen
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Jens Hohwü Voigt
Jens Hohwü Voigt
Steno Diabetes Center Aarhus, Aarhus, Denmark
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Steen Bønløkke Pedersen
Steen Bønløkke Pedersen
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Troels K Hansen
Troels K Hansen
Steno Diabetes Center Aarhus, Aarhus, Denmark
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Niels Møller
Niels Møller
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Niels Jessen
Niels Jessen
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Biomedicine, Aarhus University, Aarhus, Denmark
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Department of Biomedicine, Aarhus University, Aarhus, Denmark
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Lars C Gormsen
Lars C Gormsen
Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
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Esben Søndergaard
Esben Søndergaard
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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food intake ( 5 , 6 ). Therefore, SGLT2 inhibitors may not only affect whole-body lipolysis but also regional lipid storage. However, this has not yet been investigated. Adipose tissue is an energy reservoir that stores fatty acids as triglyceride
Davoud Jafari-Gharabaghlou
Davoud Jafari-Gharabaghlou
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Mostafa Vaghari-Tabari
Mostafa Vaghari-Tabari
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Hajar Oghbaei
Hajar Oghbaei
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
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Laura Lotz
Laura Lotz
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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Reza Zarezadeh
Reza Zarezadeh
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Yeganeh Rastgar Rezaei
Yeganeh Rastgar Rezaei
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Mahnaz Ranjkesh
Mahnaz Ranjkesh
Medical Radiation Science Research Group (MRSRG), Tabriz University of Medical Sciences, Tabriz, Iran
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Mohammad Nouri
Mohammad Nouri
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Amir Fattahi
Amir Fattahi
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Saba Nikanfar
Saba Nikanfar
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Ralf Dittrich
Ralf Dittrich
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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-like factors called adipokines. Adipokines are a kind of cytokine that contributes to energy metabolism, inflammation, immunity, and angiogenesis, as well as, reproductive maturity and fertility ( 6 , 7 , 8 , 9 ). Regarding the latter effect, it has been
Anna Eremkina
Anna Eremkina
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Julia Krupinova
Julia Krupinova
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Ekaterina Dobreva
Ekaterina Dobreva
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Anna Gorbacheva
Anna Gorbacheva
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Ekaterina Bibik
Ekaterina Bibik
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Margarita Samsonova
Margarita Samsonova
Faculty of Fundamental Medicine, ederal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University, Moscow, Russia
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Alina Ajnetdinova
Alina Ajnetdinova
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Natalya Mokrysheva
Natalya Mokrysheva
Endocrinology Research Center, Russian Federation, Moscow, Russia
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Parathyroid Pathology. The analysis included the biochemical markers of calcium-phosphorus metabolism: albumin-adjusted serum calcium concentrations (Ca, reference range (RR) 2.15–2.55 mmol/L), phosphate (P, RR 0.74–1.52 mmol/L), total alkaline phosphatase
Yael Sofer
Yael Sofer
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Nava Nevo
Nava Nevo
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
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Michal Vechoropoulos
Michal Vechoropoulos
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Gabi Shefer
Gabi Shefer
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Etty Osher
Etty Osher
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Nathan Landis
Nathan Landis
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Karen Tordjman
Karen Tordjman
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Geoffrey L Hammond
Geoffrey L Hammond
Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
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Naftali Stern
Naftali Stern
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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the SHBG gene per se and also by an array of loci in genes involved in biologic networks such as liver function, lipid metabolism, glucose metabolism, androgen and estrogen receptor function and epigenetic effects ( 29 ). Recent studies have also
