Search Results

You are looking at 61 - 70 of 547 items for :

  • development x
Clear All
Open access

Elizabeth Micks, Greta B Raglan and Jay Schulkin

these issues (6) . Reducing unmet need for family planning represents one of the most effective strategies for improving maternal health (7) , and progestogens remain one of the most promising avenues for contraceptive research and development. However

Open access

Legh Wilkinson, Nicolette J D Verhoog and Ann Louw

signalling, often resulting in various peripheral effects, one of which is the tissue-specific reductions in the glucocorticoid receptor α (GRα) functional pool. This reduction in the GRα functional pool may ultimately drive the development of acquired GC

Open access

Yiqiong Ma, Zhaowei Chen, Yu Tao, Jili Zhu, Hongxia Yang, Wei Liang and Guohua Ding

progression of DN ( 13 ). Our previous studies confirmed that high levels of glucose cause mitochondrial ROS production and increases the podocyte apoptosis rate ( 14 , 15 ). However, whether mitochondrial dynamics contribute to the development and

Open access

Doron Weinstein, Rive Sarfstein, Zvi Laron and Haim Werner

are effectively used in clinical settings (2, 4) . The insulin-like growth factor (IGF) system has an important role in the normal growth and development of the prostate gland (5) . In addition to its physiological role, epidemiological, clinical

Open access

Ram P Narayanan, Bo Fu, Adrian H Heald, Kirk W Siddals, Robert L Oliver, Julie E Hudson, Antony Payton, Simon G Anderson, Anne White, William E R Ollier and J Martin Gibson

development and progression of diabetic kidney disease is influenced by a number of biological factors. Among these, the insulin-like growth factor (IGF) family of proteins have been repeatedly implicated in the development of nephropathy and other

Open access

Qi Che, Xirong Xiao, Jun Xu, Miao Liu, Yongning Lu, Suying Liu and Xi Dong

-rabbit or anti-mouse secondary antibody (Cell Signaling Technology). The labeled proteins were detected by enhanced chemiluminescense. β-actin was used as an internal control. Development of an orthotopic endometrial carcinoma model in nude mice

Open access

Angelica Lindén Hirschberg

hypothalamic disturbance due to energy deficiency and PCOS. Differences/disorders of sex development A few women are born with rare conditions, referred to as differences/disorders of sex development (DSD), in which the development of chromosomal

Open access

Shenglong Le, Leiting Xu, Moritz Schumann, Na Wu, Timo Törmäkangas, Markku Alén, Sulin Cheng and Petri Wiklund

Introduction Sex steroids are important regulators of pubertal development and their biological action is governed by sex hormone-binding globulin (SHBG) ( 1 ). Serum SHBG levels rise from birth to early childhood, then decline in early

Open access

Nafiye Helvaci, Erdem Karabulut, Ahmet Ugur Demir and Bulent Okan Yildiz

dysfunction, decreased quality of life and increased risk of accidents. There is also strong evidence suggesting that OSA contributes to the development of hypertension, cardiovascular disease and abnormalities in glucose metabolism ( 6 , 7 , 8 ). According

Open access

Katherine Van Loon, Li Zhang, Jennifer Keiser, Cendy Carrasco, Katherine Glass, Maria-Teresa Ramirez, Sarah Bobiak, Eric K Nakakura, Alan P Venook, Manisha H Shah and Emily K Bergsland

symptoms, and the development of any SRE were abstracted. Bone metastases were considered synchronous if they were identified within 3 months of diagnosis of the primary tumor. If bone metastases were identified beyond 3 months after diagnosis, they were