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/paracrine signaling ( 14 , 21 ). FGF1 has originally detected expression in rodents and human adipose tissue ( 22 , 23 ). Furthermore, FGF1-knockout mice developed severe hyperglycemia and IR accompanied by elevated inflammation in the adipose tissue when challenged
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Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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nervous system (SNS), which increases release of neurotransmitters such as norepinephrine, stimulates bone resorption through an enhanced RANKL secretion by osteoblasts (OBs). In the bone marrow adipose tissue (BMAT), adipocytes undergo lipolysis to
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, respectively. Insulin stimulates glucose uptake in muscle and adipose tissues through glucose transporter (GLUT4) translocation to cell surface. Besides that, other crucial step to glucose uptake is its phosphorylation in a reaction catalyzed by the enzyme
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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