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-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-γ coactivator-1α in rats . Pediatric Research 2015 77 625 – 632 . ( https://doi.org/10.1038/pr.2015.32 ) 17 Liu W Singh R Choi CS Lee HY Keramati AR Samuel VT
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with up to 50% of mUPD in children presenting now, possibly due to increased maternal ages ( 17 , 18 ). In suspected cases, specific PWS genetic analysis should be requested, with genetic analysis initially assessing the methylation pattern of the
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and cognitive development ( 86 ). BPA exposure also causes epigenetic changes (methylation) on the ER-α gene in the cortex and hypothalamus of male and female mice and alters mRNA levels of DNA methyltransferases DNMT1 and DNMT3A ( 78 , 87