Xiaoli Jin
Xiaoli Jin
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Jiankang Shen
Jiankang Shen
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Tao Liu
Tao Liu
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Ru Zhou
Ru Zhou
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Xunbo Huang
Xunbo Huang
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Tianxiang Wang
Tianxiang Wang
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Weize Wu
Weize Wu
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Mingliang Wang
Mingliang Wang
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Rongli Xie
Rongli Xie
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Jianming Yuan
Jianming Yuan
Department of General Surgery, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Introduction Thyroid cancer is one of the most common malignant tumors, and papillary thyroid carcinoma (PTC) is the most common histologic type ( 1 ). Surgery remains the most effective treatment for thyroid cancer. However, postoperative
Weiwei Liang
Weiwei Liang
W Liang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Junxin Chen
Junxin Chen
J Chen, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guang Zhou, China
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Hai Li
Hai Li
H Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Pengyuan Zhang
Pengyuan Zhang
P Zhang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Hongyu Guan
Hongyu Guan
H Guan, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Yanbing Li
Yanbing Li
Y Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guanzhou, China
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Background: Collagen type VIII α 1 chain (COL8A1), a collagen type VIII protein, has been suggested to exert various functions in progression of multiple cancers. However, the effect of COL8A1 in papillary thyroid cancer (PTC) has not been elucidated.
Methods: The Cancer Genome Atlas (TCGA) databases were applied to investigate the COL8A1 expression and its clinical significance in PTC. The COL8A1 expression level was further validated using Gene Expression Omnibus (GEO) data and clinical paired PTC tissues. Additionally, Kaplan-Meier curve was used to analyze the prognosis. The cell migrative and invasive abilities were evaluated by wound healing assay and Transwell assay. CCK8 assays were used to evaluate proliferation of PTC cells. Western blotting was conducted to explore the potential mechanisms involved in the pro-tumor role of COL8A1. The correlation between immune cell infiltration and COL8A1 was analyzed using Tumor Immune Estimation Resource (TIMER) database and the single-sample GSEA (ssGSEA) method.
Results: We found that COL8A1 was upregulated in PTC (P<0.05). High COL8A1 expression level was significantly associated with advanced T stage (P<0.01), N stage (P<0.001) and poor prognosis (P=0.0142) in PTC. Furthermore, cell migration and invasion were significantly reduced following COL8A1 knockdown (P<0.001). Mechanistic studies demonstrated that the epithelial-to-mesenchymal transition (EMT) related proteins (FN1, MMP9, MMP7, ZEB2 and Twist1) and phosphorylation of AKT and ERK were obviously down-regulated after COL8A1 knockdown (P<0.01). Moreover, COL8A1 expression was correlated with immune cell infiltration.
Conclusion: Our study demonstrates that COL8A1 may function as an oncogene and a potential prognostic biomarker for PTC patients.
Tiemo S Gerber
Tiemo S Gerber
Endocrine Surgery Section, Department of General, Visceral and Transplantation Surgery, University Medicine, Mainz, Germany
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Arno Schad
Arno Schad
Department of Pathology, University Medicine, Mainz, Germany
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Nils Hartmann
Nils Hartmann
Department of Pathology, University Medicine, Mainz, Germany
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Erik Springer
Erik Springer
Department of Pathology, University Medicine, Mainz, Germany
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Ulrich Zechner
Ulrich Zechner
Institute of Human Genetics, University Medicine, Mainz, Germany
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Thomas J Musholt
Thomas J Musholt
Endocrine Surgery Section, Department of General, Visceral and Transplantation Surgery, University Medicine, Mainz, Germany
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Introduction Poorly differentiated thyroid carcinoma (PDTC) represents an aggressive variant of thyroid cancer that predominantly arises from the differentiated variants of papillary and follicular thyroid carcinoma (PTC and FTC, respectively
Rui M B Maciel
Rui M B Maciel
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Cleber P Camacho
Cleber P Camacho
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Lígia V M Assumpção
Lígia V M Assumpção
Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil
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Natassia E Bufalo
Natassia E Bufalo
Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil
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André L Carvalho
André L Carvalho
Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil
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Gisah A de Carvalho
Gisah A de Carvalho
Faculdade de Medicina, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
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Luciana A Castroneves
Luciana A Castroneves
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil
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Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil
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Francisco M de Castro Jr
Francisco M de Castro Jr
Universidade Federal do Ceará, Fortaleza, Ceará, Brazil
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Lucieli Ceolin
Lucieli Ceolin
Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Janete M Cerutti
Janete M Cerutti
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Rossana Corbo
Rossana Corbo
Instituto Nacional do Câncer, Rio de Janeiro, Rio de Janeiro, Brazil
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Tânia M B L Ferraz
Tânia M B L Ferraz
Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil
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Carla V Ferreira
Carla V Ferreira
Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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M Inez C França
M Inez C França
Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil
Hospital Santa Rita de Cássia, Vitória, Espírito Santo, Brazil
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Hospital Santa Rita de Cássia, Vitória, Espírito Santo, Brazil
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Henrique C R Galvão
Henrique C R Galvão
Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil
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Fausto Germano-Neto
Fausto Germano-Neto
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Hans Graf
Hans Graf
Faculdade de Medicina, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
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Alexander A L Jorge
Alexander A L Jorge
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
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Ilda S Kunii
Ilda S Kunii
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Márcio W Lauria
Márcio W Lauria
Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Vera L G Leal
Vera L G Leal
Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, Rio de Janeiro, Brazil
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Susan C Lindsey
Susan C Lindsey
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Delmar M Lourenço Jr
Delmar M Lourenço Jr
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil
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Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil
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Léa M Z Maciel
Léa M Z Maciel
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
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Patrícia K R Magalhães
Patrícia K R Magalhães
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
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João R M Martins
João R M Martins
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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M Cecília Martins-Costa
M Cecília Martins-Costa
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil
Universidade de Fortaleza, Fortaleza, Ceará, Brazil
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Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil
Universidade de Fortaleza, Fortaleza, Ceará, Brazil
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Gláucia M F S Mazeto
Gláucia M F S Mazeto
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil
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Anelise I Impellizzeri
Anelise I Impellizzeri
Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Célia R Nogueira
Célia R Nogueira
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil
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Edenir I Palmero
Edenir I Palmero
Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil
Faculdade de Ciências da Saúde de Barretos Dr. Paulo Prata, Barretos, São Paulo, Brazil
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Faculdade de Ciências da Saúde de Barretos Dr. Paulo Prata, Barretos, São Paulo, Brazil
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Cencita H C N Pessoa
Cencita H C N Pessoa
Instituto Nacional do Câncer, Rio de Janeiro, Rio de Janeiro, Brazil
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Bibiana Prada
Bibiana Prada
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil
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Débora R Siqueira
Débora R Siqueira
Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Maria Sharmila A Sousa
Maria Sharmila A Sousa
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
Escola Fiocruz de Governo, Fundação Oswaldo Cruz and Ministério da Saúde, Brasília, Distrito Federal, Brazil
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Escola Fiocruz de Governo, Fundação Oswaldo Cruz and Ministério da Saúde, Brasília, Distrito Federal, Brazil
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Rodrigo A Toledo
Rodrigo A Toledo
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Vall d’Hebron Institute of Oncology (VHIO), CIBERONC, Barcelona, Spain
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Vall d’Hebron Institute of Oncology (VHIO), CIBERONC, Barcelona, Spain
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Flávia O F Valente
Flávia O F Valente
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Fernanda Vaisman
Fernanda Vaisman
Instituto Nacional do Câncer, Rio de Janeiro, Rio de Janeiro, Brazil
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Laura S Ward
Laura S Ward
Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil
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Shana S Weber
Shana S Weber
Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Rita V Weiss
Rita V Weiss
Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, Rio de Janeiro, Brazil
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Ji H Yang
Ji H Yang
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Magnus R Dias-da-Silva
Magnus R Dias-da-Silva
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
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Ana O Hoff
Ana O Hoff
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil
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Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil
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Sergio P A Toledo
Sergio P A Toledo
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
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Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
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Ana L Maia
Ana L Maia
Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Brazilian centers involved in the diagnosis and treatment of thyroid cancer. Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported
Rasmus Reinke
Rasmus Reinke
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Stefano Christian Londero
Stefano Christian Londero
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Martin Almquist
Martin Almquist
Department of Surgery, Lund University Hospital, Lund, Sweden
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Lars Rejnmark
Lars Rejnmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Lars Rolighed
Lars Rolighed
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer . Thyroid 2016 26 1 – 133 . ( https://doi.org/10.1089/thy.2015.0020 ) 25 McWade MA Sanders ME Broome JT Solorzano
Adrian F Daly
Adrian F Daly
Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
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Liliya Rostomyan
Liliya Rostomyan
Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
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Daniela Betea
Daniela Betea
Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
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Jean-François Bonneville
Jean-François Bonneville
Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
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Chiara Villa
Chiara Villa
Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France
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Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France
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Natalia S Pellegata
Natalia S Pellegata
Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany
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Beatrice Waser
Beatrice Waser
Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland
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Jean-Claude Reubi
Jean-Claude Reubi
Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland
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Catherine Waeber Stephan
Catherine Waeber Stephan
Clinique Générale Ste-Anne, Fribourg, Switzerland
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Emanuel Christ
Emanuel Christ
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland
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Albert Beckers
Albert Beckers
Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
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, which was performed under an approval of the Ethics Committee of the Centre Hospitalier Universitaire de Liège. Immunohistochemistry AIP immunostaining of paraffin preserved tumor tissue (pituitary in Patient 2 and thyroid cancer in the sister of
Dario de Biase
Dario de Biase
Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy
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Federica Torricelli
Federica Torricelli
Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Moira Ragazzi
Moira Ragazzi
Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Benedetta Donati
Benedetta Donati
Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Elisabetta Kuhn
Elisabetta Kuhn
Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Michela Visani
Michela Visani
Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
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Giorgia Acquaviva
Giorgia Acquaviva
Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
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Annalisa Pession
Annalisa Pession
Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy
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Giovanni Tallini
Giovanni Tallini
Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
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Simonetta Piana
Simonetta Piana
Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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Alessia Ciarrocchi
Alessia Ciarrocchi
Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy
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of thyroid cancer ( 3 ). It represents 1–2% of clinically recognized thyroid malignancies but it accounts for more than half of the deaths for thyroid cancer. Five-year survival rate for ATC patients is estimated below 1% and about 50% of ATC patients
Luchuan Li
Luchuan Li
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Baoyuan Li
Baoyuan Li
Department of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China
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Bin Lv
Bin Lv
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Weili Liang
Weili Liang
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Binbin Zhang
Binbin Zhang
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Qingdong Zeng
Qingdong Zeng
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Andrew G Turner
Andrew G Turner
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia
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Lei Sheng
Lei Sheng
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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( 8 , 9 ). Moreover, several authors have described a rate of thyroid cancer in patients with PHPT that appears to be higher than the general population ( 4 , 10 , 11 , 12 , 13 , 14 , 15 ). A review of data from nine studies, including a total
T P McVeigh
T P McVeigh
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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R J Mulligan
R J Mulligan
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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U M McVeigh
U M McVeigh
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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P W Owens
P W Owens
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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N Miller
N Miller
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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M Bell
M Bell
Department of Endocrinology, School of Medicine, NUI Galway, Galway, Ireland
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F Sebag
F Sebag
Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France
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Aix-Marseille Université, Faculté de Médecine, Marseille, France
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C Guerin
C Guerin
Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France
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Aix-Marseille Université, Faculté de Médecine, Marseille, France
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D S Quill
D S Quill
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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J B Weidhaas
J B Weidhaas
David Geffen School of Medicine, University of California, Los Angeles, USA
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M J Kerin
M J Kerin
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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A J Lowery
A J Lowery
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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remained ill-defined. A recent meta-analysis has revisited the possibility of such an association and has confirmed the existence of, and quantified the increased co-occurrence of breast and differentiated thyroid cancer (DTC) ( 1 ). Both cancers occur
Xu-Feng Chen
Xu-Feng Chen
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Cong He
Cong He
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Peng-Cheng Yu
Peng-Cheng Yu
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Wei-Dong Ye
Wei-Dong Ye
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Pei-Zheng Han
Pei-Zheng Han
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Jia-Qian Hu
Jia-Qian Hu
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Yu-Long Wang
Yu-Long Wang
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
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clinical practice. NGS reveals the comprehensive genetic background of a certain tumor, thus assisting tumor diagnosis and treatment. Thyroid cancer is the most common endocrine malignancy with an increasing incidence ( 2 ) in recent decades. Exciting
