P G Murray
P G Murray
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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D Hanson
D Hanson
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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T Coulson
T Coulson
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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A Stevens
A Stevens
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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A Whatmore
A Whatmore
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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R L Poole
R L Poole
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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D J Mackay
D J Mackay
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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G C M Black
G C M Black
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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P E Clayton
P E Clayton
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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transcription factor expressed in the developing skeleton (19) , and HOXA9 , a transcription factor involved in myeloid differentiation linked with increased cell proliferation in leukaemia (20) . Other upregulated genes included GPC6 (loss of function
Frederic Schrøder Arendrup
Frederic Schrøder Arendrup
Department of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, Denmark
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Severine Mazaud-Guittot
Severine Mazaud-Guittot
Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France
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Bernard Jégou
Bernard Jégou
Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France
EHESP-School of Public Health, Rennes, France
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EHESP-School of Public Health, Rennes, France
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David Møbjerg Kristensen
David Møbjerg Kristensen
Department of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, Denmark
Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France
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Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France
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Nanog that are characteristic for early embryonic stem cells ( 21 , 22 , 23 ). The exact nature of the migration related to proliferation is not clear; some evidence points to PGCs halting mitosis until colonizing the gonadal ridge ( 24 ), whereas
Giuseppe Lisco
Giuseppe Lisco
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Anna De Tullio
Anna De Tullio
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Olga Disoteo
Olga Disoteo
Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
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Giuseppina Piazzolla
Giuseppina Piazzolla
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Edoardo Guastamacchia
Edoardo Guastamacchia
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Carlo Sabbà
Carlo Sabbà
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Vincenzo De Geronimo
Vincenzo De Geronimo
Unit of Endocrinology, Policlinico Morgagni CCD, Catania, Italy
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Enrico Papini
Enrico Papini
Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy
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Vincenzo Triggiani
Vincenzo Triggiani
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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were described, but a dose eight times higher than the greatest approved dose of liraglutide in humans was related to a potential carcinogenic factor ( 8 ). Evidence suggests that GLP-1RAs exert a dose-dependent effect on cell proliferation in thyroid
Yu Lin
Yu Lin
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Yingying Zhang
Yingying Zhang
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Lei Xu
Lei Xu
Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China
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Wei Long
Wei Long
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Chunjian Shan
Chunjian Shan
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Hongjuan Ding
Hongjuan Ding
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Lianghui You
Lianghui You
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Chun Zhao
Chun Zhao
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Zhonghua Shi
Zhonghua Shi
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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homogenized. Subsequently, the cell suspension was retained to detect the triglyceride and protein concentrations. Proliferation assay Cell proliferation assay was performed using the CellTrace™ Far Red Cell Proliferation kit (Invitrogen) for flow
Zuyao Chen
Zuyao Chen
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Xiaolin Zhong
Xiaolin Zhong
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Weiqiang Tang
Weiqiang Tang
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Min Xia
Min Xia
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Chang Liu
Chang Liu
Department of Endocrinology and Metabolism, The First People's Hospital of Chenzhou, Chenzhou, China
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Yinping Guo
Yinping Guo
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Yan Yi
Yan Yi
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Qingshan Jiang
Qingshan Jiang
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Xuyu Zu
Xuyu Zu
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Jing Zhong
Jing Zhong
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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cases have shown distant metastasis in the bones and lungs ( 3 ). Additionally, the clinical outcomes of PTC patients with high invasion and proliferation remain poor ( 4 ). ATC accounts for less than 2% of all TCs but results in nearly one-third of TC
E T Aristizabal Prada
E T Aristizabal Prada
Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany
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C J Auernhammer
C J Auernhammer
Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany
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MK-2206 in NET cell lines demonstrated a decrease in pAKT expression, inhibition of proliferation and induction of apoptosis mechanisms and a decreased expression of the NET tumour markers CgA and NSE ( 79 ). In a clinical phase 1 study with MK-2206
Maria Cristina De Martino
Maria Cristina De Martino
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Richard A Feelders
Richard A Feelders
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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Claudia Pivonello
Claudia Pivonello
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Chiara Simeoli
Chiara Simeoli
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Fortuna Papa
Fortuna Papa
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Annamaria Colao
Annamaria Colao
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Rosario Pivonello
Rosario Pivonello
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy
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Leo J Hofland
Leo J Hofland
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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of mTOR as part of the mTORC1 complex. Activated mTORC1 complex regulates cell proliferation via the activation of mRNA translation and is mediated mainly via two downstream components, i.e. p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic
Chiara Mele
Chiara Mele
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Maria Teresa Samà
Maria Teresa Samà
Division of Endocrinology, University Hospital ‘Maggiore della Carità’, Novara, Italy
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Alessandro Angelo Bisoffi
Alessandro Angelo Bisoffi
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
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Marina Caputo
Marina Caputo
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
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Valentina Bullara
Valentina Bullara
Division of Endocrinology, University Hospital ‘Maggiore della Carità’, Novara, Italy
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Stefania Mai
Stefania Mai
Laboratory of Metabolic Research, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Gillian Elisabeth Walker
Gillian Elisabeth Walker
Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
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Flavia Prodam
Flavia Prodam
Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
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Paolo Marzullo
Paolo Marzullo
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Gianluca Aimaretti
Gianluca Aimaretti
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
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Loredana Pagano
Loredana Pagano
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy
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Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy
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cellular signalling cascades, enhancing growth factor-dependent cell proliferation and/or by directly affecting cell metabolism ( 11 ). Other factors potentially implicated in the loop linking obesity and IR to DTC could be represented by ghrelin, an
Ling Hu
Ling Hu
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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Ting Li
Ting Li
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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Xiao-Ling Yin
Xiao-Ling Yin
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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Yi Zou
Yi Zou
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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IR and that high serum insulin levels are an important feature of MS patients. It has also been reported that IR may cause the proliferation of thyroid cells ( 16 ), promote the formation of TN, and even progress into thyroid carcinoma. Rezzonico et
M L Gild
M L Gild
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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M Bullock
M Bullock
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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C K Pon
C K Pon
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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B G Robinson
B G Robinson
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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R J Clifton-Bligh
R J Clifton-Bligh
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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signaling kinases. HSPs have become known as central regulators, whose actions are to control the activity of pathways such as cell proliferation and death, while preventing the aggregation of non-native proteins (1) . HSP90 is overexpressed in cancer cells
