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Richard H Tuligenga INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France
INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France

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Kanaya AM Barrett-Connor E Gildengorin G Yaffe K . Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort . Archives of Internal Medicine 2004 164 1327

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Xun Gong Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Lili You Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Feng Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Qingyu Chen Department of Medical Examination Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China

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Chaogang Chen Department of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China

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Xiaoyun Zhang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Xiuwei Zhang Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China

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Wenting Xuan Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China

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Kan Sun Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Guojuan Lao Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Chuan Wang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Yan Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Mingtong Xu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Meng Ren Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Li Yan Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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older adults than young adults. One study regarded adiponectin resistance as an explanation for the higher adiponectin level with age ( 24 ). Previous research found that plasma adiponectin levels were lower in elderly subjects with pre-diabetes than in

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Rongpeng Gong Medical College, Qinghai University, Xining, People’s Republic of China

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Gang Luo College of Eco-Environmental Engineering, Qinghai University, Xining, People’s Republic of China

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Mingxiang Wang Medical College, Qinghai University, Xining, People’s Republic of China

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Lingbo Ma Medical College, Qinghai University, Xining, People’s Republic of China

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Shengnan Sun Medical College, Qinghai University, Xining, People’s Republic of China

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Xiaoxing Wei Medical College, Qinghai University, Xining, People’s Republic of China

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), and the presence of IR has been linked to metabolic disturbances in several studies ( 9 ). Furthermore, IR is most likely to intensify those conditions and increase death rate from all causes ( 10 , 11 , 12 ). Welsh et al . found that older adults

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Ranganathan R Rao Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Harpal S Randeva Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Sailesh Sankaranarayanan Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Murthy Narashima Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Matthias Möhlig Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Hisham Mehanna Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Martin O Weickert Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
Warwickshire Institute for the Study of Diabetes, Warwick Medical School, Department of Endocrinology, Institute of Head and Neck Studies and Education (InHANSE), Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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performance in older adults . American Journal of Geriatric Psychiatry 2006 14 1032 – 1040 . ( doi:10.1097/01.JGP.0000240986.74642.7c ). 10 Silverberg SJ . Vitamin D deficiency and primary hyperparathyroidism . Journal of Bone and Mineral Research

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Natércia Neves Marques de Queiroz University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Franciane Trindade Cunha de Melo University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Fabrício de Souza Resende University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Luísa Corrêa Janaú University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Norberto Jorge Kzan de Souza Neto University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Manuela Nascimento de Lemos University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Ana Carolina Lobato Virgolino University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Maria Clara Neres Iunes de Oliveira University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Angélica Leite de Alcântara University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Lorena Vilhena de Moraes University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Tiago Franco David University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Wanderson Maia da Silva University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Scarlatt Souza Reis University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Márcia Costa dos Santos University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Ana Carolina Contente Braga de Souza University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Pedro Paulo Freire Piani University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Neyla Arroyo Lara Mourão University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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Karem Mileo Felício University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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João Felício Abrahão Neto University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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João Soares Felício University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, Brazil

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separately, in order to properly interpret their data. Information regarding age, sex, BMI and living zone were collected. Patients were divided according to the age groups defined by WHO, in 2013, as children (0–9 years old), teenagers (10–19 years old

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Martine Cohen-Solal Department of Skeletal Diseases, INSERM U1132 & Université de Paris, Hôpital Lariboisière, Paris, France

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Thomas Funck-Brentano Department of Skeletal Diseases, INSERM U1132 & Université de Paris, Hôpital Lariboisière, Paris, France

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Pablo Ureña Torres AURA Nord, Saint Ouen, France
Department of Renal Physiology, Necker Hospital, Université de Paris, Paris, France

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increased risk of hip fracture ( 14 ). US Medicare data collected in hemodialysis patients identified downward hip-fracture incidence trends from 2000 to late 2009 ( 2 ), although most prominent in older adults of both genders ( 15 ). Indeed, the incidence

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Selina Mäkinen Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Neeta Datta Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Yen H Nguyen Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Petro Kyrylenko Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Markku Laakso Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland

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Heikki A Koistinen Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Primary prevention with statins for older adults . BMJ 2018 362 k3695. ( https://doi.org/10.1136/bmj.k3695 ) 4 Spector R Snapinn SM Statins for secondary prevention of cardiovascular disease: the right dose . Pharmacology 2011 87 63 – 69

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Miranda Scharff Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands

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Chantal Maria Wiepjes Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands

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Maartje Klaver Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands

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Thomas Schreiner Department of Endocrinology, Oslo University Hospital, Oslo, Norway

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Guy T’Sjoen Department of Endocrinology & Center for Sexology and Gender, Ghent University Hospital, Ghent, Belgium

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Martin den Heijer Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands

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. Sarcopenia in older adults . Current Opinion in Rheumatology 2012 24 . ( https://doi.org/10.1097/BOR.0b013e328358d59b ) 22955023 3 Clark BC Manini TM . What is dynapenia? Nutrition 2012 28 . ( https://doi.org/10.1016/j.nut.2011

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Xu Chen Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China

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Yi Tang Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China

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Shen Chen Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Wenhua Ling Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China

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Qing Wang Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China

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insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the health, aging, and body composition study . Journal of the American Geriatrics Society 2009 57 1213 – 1218 . ( https://doi.org/10.1111/j.1532-5415.2009.02318.x ) 17

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Sharon A Huish University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
The University of Warwick, Coventry, UK
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK

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Carl Jenkinson The University of Birmingham, Birmingham, UK

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Janet A Dunn The University of Warwick, Coventry, UK

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David J Meredith Royal Devon and Exeter NHS Foundation Trust, Exeter, UK

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Rosemary Bland The University of Warwick, Coventry, UK

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Martin Hewison The University of Birmingham, Birmingham, UK

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Chonchol M Shlipak MG Sarnak MJ Hoofnagle AN Rifkin DE Garimella PS The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: the cardiovascular health study . Bone 2018 107 124 – 130 . ( https://doi.org/10.1016/j.bone.2017

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