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Wenrui Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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Chuan Zhang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages . Redox Biology 2018 15 170 – 181 . ( https://doi.org/10.1016/j.redox.2017.12.001 ) 70 Lou Y Kong M Li L Hu Y Zhai W Qi X Liu

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Feifei Cheng Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Noel Yat Hey Ng Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Claudia Ha Ting Tam Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Yuying Zhang Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Cadmon King Poo Lim Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Guozhi Jiang Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Alex Chi Wai Ng Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Tiffany Tse Ling Yau Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Lai Ping Cheung Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Aimin Xu Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong
State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong
Department of Pharmacy and Pharmacology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong

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Juliana C N Chan Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong

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Ronald C W Ma Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong

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-h plasma glucose 7.8–11.0 mmol; (3) DM, FPG ≥ 7.0 mmol, or symptoms of hyperglycaemia and a random plasma glucose ≥ 11.1 mmol, or 2-h plasma glucose ≥ 11.1 mmol during OGTT, or self-reported history of DM. The diabetes converters were defined as the

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K Amrein Thyroid Endocrinology Osteoporosis Institute Dobnig, Graz, Austria
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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A Papinutti Department of General Surgery, Medical University of Graz, Graz, Austria

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E Mathew Department of General Surgery, Medical University of Graz, Graz, Austria
Department of General Surgery, St. Elisabeth’s Hospital, Graz, Austria

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G Vila Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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D Parekh Clinician Scientist in Critical Care, Birmingham, Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK

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vitamin D on stress-induced hyperglycaemia and insulin resistance in critically ill patients . International Journal of Clinical Practice 2016 70 396 – 405 . 87 Miroliaee AE Salamzadeh J Shokouhi S Fatemi A Ardehali SH Hajiesmaeili MR

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Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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Fredrik Karpe Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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hepatic glycogen storage, in conjunction with hyperinsulinaemia due to a combination of increased insulin secretion and decreased insulin clearance. Biddinger et al. ( 63 ) reported that despite hyperglycaemia and hyperinsulinaemia, the LIRKO mice had

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Sara Ullsten Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Sara Bohman Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Marie E Oskarsson Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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K Peter R Nilsson Department of Chemistry, Linköping University, Linköping, Sweden

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Gunilla T Westermark Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Per-Ola Carlsson Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Kahn SE . Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets . Diabetologia 2009 52 145 – 153 . ( doi:10.1007/s00125-008-1185-7 ) 19002432 10.1007/s00125-008-1185-7 14

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Cecília Cristelo i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

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Alexandra Machado CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

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Bruno Sarmento i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal

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Francisco Miguel Gama CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

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Type 1 diabetes Diabetes mellitus refers to a group of metabolic diseases characterised by chronic hyperglycaemia due to absent insulin secretion, insulin action or both ( 1 ). Diabetes is classically divided in type 1 and type 2 diabetes ( 2

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T Grimmichova Institute of Endocrinology, Narodni, Prague, Czech Republic
2nd Department of Internal Medicine, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, Srobarova, Prague, Czech Republic

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M Haluzik Institute of Endocrinology, Narodni, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska, Prague, Czech Republic

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K Vondra Institute of Endocrinology, Narodni, Prague, Czech Republic

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P Matucha Institute of Endocrinology, Narodni, Prague, Czech Republic

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M Hill Institute of Endocrinology, Narodni, Prague, Czech Republic

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Diamant M Ferrannini E Nauck M Peters AL Tsapas A Wender R Matthews DR . Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European

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Mai Morsi Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Braunschweig, Germany

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Torben Schulze Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Braunschweig, Germany

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Eike Früh Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Braunschweig, Germany

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Dennis Brüning Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Braunschweig, Germany

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Uwe Panten Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Braunschweig, Germany

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Ingo Rustenbeck Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, Braunschweig, Germany

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) S117 – S121 . ( https://doi.org/10.2337/diabetes.51.2007.s117 ) 5 Del Prato S . Loss of early insulin secretion leads to postprandial hyperglycaemia . Diabetologia 2003 46 ( Supplement 1 ) M2 – M8 . ( https://doi.org/10.1007/s00125

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Earn H Gan Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Wendy Robson Urology Unit, Freeman Hospital, Newcastle upon Tyne, UK

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Peter Murphy Urology Unit, Freeman Hospital, Newcastle upon Tyne, UK

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Robert Pickard Urology Unit, Freeman Hospital, Newcastle upon Tyne, UK
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

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Simon Pearce Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Rachel Oldershaw Department of Musculoskeletal Biology, Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, UK

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lymphocytes and inflammatory dendritic cells, leading to long-term reversal of hyperglycaemia ( 32 , 42 , 43 ). With this in mind, an understanding of the cell biology of adrenal-derived MSCs will be essential to the regenerative medicine approach in AAD as

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Ewa Stogowska Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland

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Karol Adam Kamiński Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, Bialystok, Poland

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Bartosz Ziółko Techmo, Kraków, Poland

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Irina Kowalska Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland

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observed symptom is muscle weakness, which possibly can impair the function of laryngeal muscles, affecting the voice parameters. Type 2 diabetes mellitus DM, as a state of chronic hyperglycaemia, appears as a consequence of insulin resistance of

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