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Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK
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fragility fractures occur in individuals who do not have low BMD ( 2 ) and it is possible that the poor sensitivity of DXA can be attributed to its inability to capture all aspects of bone structure and quality that influence bone strength. The link between
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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these bone characteristics may explain the increased fracture risk observed in this population ( 7 ). Various endocrine and metabolic disturbances, including hypothyroidism ( 8 ), hypogonadism ( 1 , 9 , 10 ), hypercortisolism ( 2 , 11 ) and IGF-1
Disciplina de Endocrinologia, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, São Paulo, Brazil
Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular LIM/42, Disciplina de Endocrinologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil
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puberty onset/induction or estrogen dose, were not significantly different among genotypic groups. Karyotype is considered not to be associated with BMD or fracture risk by most groups ( 1 ), and was not linked to bone mass in our patients either
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Department of Clinical Research Center, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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on bone health, more recent research has revealed a positive association between obesity and bone fractures ( 6 ). Waist circumference (WC), which is an easy-to-determine clinical parameter, has been proposed to assess central obesity in
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PTH values in those with worse bone mass (9, 10.1 and 14.1 pmol/L in normal bone mass, osteopenia and osteoporosis respectively). Only two bone fractures were registered at presentation: a vertebral fracture in a 25-year-old man and a distal radius
Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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, arrhythmia, and thyroid nodules. Data on obstructive sleep apnea (OSA), coronary artery disease (CAD), heart failure, colonic polyps, bone mass (by dual-energy X-ray absorptiometry), and spinal fractures were not routinely collected as screening information
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, osteoporosis, pathological fracture, pancreatitis, etc.), laboratory blood analyses within 1 week prior to surgery (PTH, calcium, 25-hydroxyvitamin D (25(OH)D), albumin, phosphorus, potassium, alkaline phosphatase (AKP), creatinine (Cr), blood urea nitrogen
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). In postmenopausal women, periostin serum levels have been associated with increased fracture risk, independently of bone mineral density, suggesting an effect on the organic rather than the mineral component of the bone ( 46 , 47 ). In addition
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Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
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Department of Renal Medicine, St George Hospital, Sydney, NSW, Australia
Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia
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in their CVOTs, HF or kidney RCTs, making it unlikely that there is any drug class risk. Bone fractures Bone fractures are a common and serious condition in older adults. Treatment of adults PPAR gamma agonists (e.g. pioglitazone) is
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on bone health. Högler et al . ( 46 ) reviewed the evidence relating to the impact of GH deficiency on bone and, in particular, reviewed all the available fracture studies. The fracture prevalence and incidence studies demonstrated evidence of