Katarzyna Wyskida
Katarzyna Wyskida
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland
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Grzegorz Franik
Grzegorz Franik
Department of Gynecological Endocrinology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland
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Tomasz Wikarek
Tomasz Wikarek
Department of Gynecology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland
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Aleksander Owczarek
Aleksander Owczarek
Department of Statistics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland
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Alham Delroba
Alham Delroba
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland
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Jerzy Chudek
Jerzy Chudek
Pathophysiology Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland
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Jerzy Sikora
Jerzy Sikora
Department of Perinatology and Gynecology, Medical University of Silesia, Katowice, Poland
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Magdalena Olszanecka-Glinianowicz
Magdalena Olszanecka-Glinianowicz
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland
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previously published studies, which revealed a reduction in adipocyte insulin receptor binding ( 22 ) and a decrease in insulin sensitivity in the luteal phase in comparison to the follicular phase of the menstrual cycle ( 23 ). Additionally, the hypothetical
Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Celine Corbisier de Meaultsart
Celine Corbisier de Meaultsart
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
Oregon Health and Science University, Portland, Oregon, USA
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Jim Scurry
Jim Scurry
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Nicole M Verrills
Nicole M Verrills
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Ang II, AGTR1 and VEGF peptides and proteins as well as adipocyte-derived leucine aminopeptidase (A-LAP), which hydrolyses Ang II ( 11 ), were prognostic, with increased expression of A-LAP, which degrades Ang II, predicting better outcomes. However
Jie Shi
Jie Shi
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Zhen Yang
Zhen Yang
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Yixin Niu
Yixin Niu
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Weiwei Zhang
Weiwei Zhang
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Ning Lin
Ning Lin
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Xiaoyong Li
Xiaoyong Li
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Hongmei Zhang
Hongmei Zhang
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Hongxia Gu
Hongxia Gu
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Jie Wen
Jie Wen
Department of Endocrinology and Metabolism, Institute of Endocrinology and Diabetes, Huashan Hospital, Fudan University, Shanghai, China
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Guang Ning
Guang Ning
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Li Qin
Li Qin
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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Qing Su
Qing Su
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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-fat deposition exhibited a more favorable metabolic profile including lower triglycerides and LDL-c ( 26 ), and thigh adipocytes were resistant to epinephrine-stimulated lipolysis, presumably due to an increase in alpha-adrenergic receptors ( 29 ). Therefore, the
J Chycki
J Chycki
Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland
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A Zajac
A Zajac
Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland
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M Michalczyk
M Michalczyk
Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland
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A Maszczyk
A Maszczyk
Department of Methodology and Statistics, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland
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J Langfort
J Langfort
Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland
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Introduction Somatotypes, which to some extent express genetic determinism, are significantly associated with the level of physical fitness ( 1 , 2 ), and as a consequence with the content of adipose tissue ( 1 ). Adipocytes are highly
Carlijn A Hoekx
Carlijn A Hoekx
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Borja Martinez-Tellez
Borja Martinez-Tellez
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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Maaike E Straat
Maaike E Straat
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Magdalena M A Verkleij
Magdalena M A Verkleij
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Mirjam Kemmeren
Mirjam Kemmeren
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Sander Kooijman
Sander Kooijman
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Martin Uhrbom
Martin Uhrbom
Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca Gothenburg, Sweden
Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden
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Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden
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Saskia C A de Jager
Saskia C A de Jager
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
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Patrick C N Rensen
Patrick C N Rensen
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Mariëtte R Boon
Mariëtte R Boon
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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secreted by activated brown adipocytes, promotes thermogenesis through both UCP1-dependent and UCP1-independent mechanisms ( 18 , 19 ). Additionally, FGF21 is secreted by the liver in a process dependent on the action of peroxisome proliferator
V Kenan Çelik
V Kenan Çelik
Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey
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Sercan Kapancık
Sercan Kapancık
Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey
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Turgut Kaçan
Turgut Kaçan
Department of Medical Oncology, High Specialized Education and Research Hospital, Bursa, Turkey
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Selen Baloglu Kaçan
Selen Baloglu Kaçan
Department of Internal Medicine, Afyonkarahisar State Hospital, Afyon, Turkey
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Serkan Kapancık
Serkan Kapancık
Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey
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Hasan Kılıçgün
Hasan Kılıçgün
Department of Nutrition and Dietetics, Health Science Faculty, University of Erzincan, Erzincan, Turkey
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Olefsky JM. Comparison of the effects of insulin and insulin-like agents on different aspects of adipocyte metabolism. Hormone and Metabolic Research 1979 11 209 – 213 . ( doi:10.1055/s-0028-1092709 ) 10.1055/s-0028-1092709 24 Richelsen B
Liselot Koelman
Liselot Koelman
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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Robin Reichmann
Robin Reichmann
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany
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Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany
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Claudia Börnhorst
Claudia Börnhorst
Department of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany
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Matthias B Schulze
Matthias B Schulze
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
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Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
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Cornelia Weikert
Cornelia Weikert
Department of Food Safety, German Federal Institute for Risk Assessment, Berlin, Germany
Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany
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Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany
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Ronald Biemann
Ronald Biemann
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
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Berend Isermann
Berend Isermann
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
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Andreas Fritsche
Andreas Fritsche
Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany
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Krasimira Aleksandrova
Krasimira Aleksandrova
Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany
Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
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Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
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chemoattractant activity on various immune cells, including macrophages, dendritic cells, and natural killer cells with key roles in both innate and adaptive immunity ( 2 ). It was further rediscovered as an adipokine that is expressed in the adipocytes and was
Sandra Pereira
Sandra Pereira
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Jessy Moore
Jessy Moore
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Jia-Xu Li
Jia-Xu Li
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Wen Qin Yu
Wen Qin Yu
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Husam Ghanim
Husam Ghanim
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Filip Vlavcheski
Filip Vlavcheski
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Yemisi Deborah Joseph
Yemisi Deborah Joseph
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Paresh Dandona
Paresh Dandona
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Allen Volchuk
Allen Volchuk
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Carolyn L Cummins
Carolyn L Cummins
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Evangelia Tsiani
Evangelia Tsiani
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Adria Giacca
Adria Giacca
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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markers of p38 MAPK activation in the liver. Interestingly, in human adipocytes, FGF21 stimulates the insulin signaling pathway at the level of Akt ( 27 ). Hence, in our study, the improvement in in vivo hepatic insulin sensitivity and in hepatic Akt
Philippe Jean-Luc Gradidge
Philippe Jean-Luc Gradidge
Centre for Exercise Science and Sports Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Nicole G Jaff
Nicole G Jaff
Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Shane A Norris
Shane A Norris
SAMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Global Health Research Institute, School of Human Development and Health, University of Southampton, Southampton, UK
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Global Health Research Institute, School of Human Development and Health, University of Southampton, Southampton, UK
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Marketa Toman
Marketa Toman
Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Nigel J Crowther
Nigel J Crowther
Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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fat mass causes adiponectin levels to rise, are not known. The physiological purpose of these opposing influences on adiponectin secretion is also not fully understood. Studies have shown that a number of factors do affect adipocyte secretion of
Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China
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Lin Zhang
Lin Zhang
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China
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Jing Fu
Jing Fu
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China
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Qiu Wang
Qiu Wang
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China
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significantly associated with PRL levels. Adipocytes of rodents and humans expressed PRL receptors ( 10 , 28 ). Previous studies found that increased PRL levels were involved in healthy expansion of adipose tissue in both rodents and humans, especially during
