Filter

Refine by collections

Refine by date

—
  • Print
  • Save

Search Results

You are looking at 61 - 70 of 279 items for :

Clear All
Sílvia Santos Monteiro Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal

Search for other papers by Sílvia Santos Monteiro in
Google Scholar
PubMed Close
,
Tiago Silva Santos Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal

Search for other papers by Tiago Silva Santos in
Google Scholar
PubMed Close
,
Ana Martins Lopes Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal

Search for other papers by Ana Martins Lopes in
Google Scholar
PubMed Close
,
José Carlos Oliveira Department of Clinical Pathology, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal

Search for other papers by José Carlos Oliveira in
Google Scholar
PubMed Close
,
Cláudia Freitas Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal

Search for other papers by Cláudia Freitas in
Google Scholar
PubMed Close
, and
André Couto Carvalho Division of Endocrinology, Diabetes and Metabolism. Department of Medicine, Centro Hospitalar Universitário do Porto, Largo Professor Abel Salazar Porto, Portugal

Search for other papers by André Couto Carvalho in
Google Scholar
PubMed Close

has not been fully established, and may be defined as a thyroid-stimulating hormone (TSH) level above the upper limit of the reference range, under a daily LT4 dose of ≥1.9 µg/kg ( 4 ). Actually, some patients still exhibit refractory hypothyroidism

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0355
Volume/Issue:
Volume 11: Issue 12
Open access
Josi Vidart Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

Search for other papers by Josi Vidart in
Google Scholar
PubMed Close
,
Paula Jaskulski Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Search for other papers by Paula Jaskulski in
Google Scholar
PubMed Close
,
Ana Laura Kunzler Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Search for other papers by Ana Laura Kunzler in
Google Scholar
PubMed Close
,
Rafael Aguiar Marschner Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Search for other papers by Rafael Aguiar Marschner in
Google Scholar
PubMed Close
,
André Ferreira de Azeredo da Silva Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Search for other papers by André Ferreira de Azeredo da Silva in
Google Scholar
PubMed Close
, and
Simone Magagnin Wajner Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Search for other papers by Simone Magagnin Wajner in
Google Scholar
PubMed Close

(T4), and elevated plasma levels of the inactive hormone reverse T3 (rT3) in the presence of normal thyrotropin (TSH) levels ( 1 ). The pathophysiology of NTIS is multifactorial. In the early phase, the peripheral TH metabolism is impaired, with

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0504
Volume/Issue:
Volume 11: Issue 2
Open access
Ling Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, People's Hospital of Liaoning Province, Shenyang, People’s Republic of China

Search for other papers by Ling Shan in
Google Scholar
PubMed Close
,
Yingying Zhou Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

Search for other papers by Yingying Zhou in
Google Scholar
PubMed Close
,
Shiqiao Peng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

Search for other papers by Shiqiao Peng in
Google Scholar
PubMed Close
,
Xinyi Wang Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Laboratory Medical, The First Hospital of China Medical University, Shenyang, People’s Republic of China

Search for other papers by Xinyi Wang in
Google Scholar
PubMed Close
,
Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

Search for other papers by Zhongyan Shan in
Google Scholar
PubMed Close
, and
Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

Search for other papers by Weiping Teng in
Google Scholar
PubMed Close

Introduction Subclinical hypothyroidism (SCH), characterized by elevated levels of thyroid-stimulating hormone (TSH) with total thyroxine (TT4) within the normal reference range, is the most common type of thyroid disorder in pregnancy ( 1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0185
Volume/Issue:
Volume 8: Issue 6
Open access
Xin He Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Xin He in
Google Scholar
PubMed Close
,
Qin Yan Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Qin Yan in
Google Scholar
PubMed Close
,
Chazhen Liu Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Chazhen Liu in
Google Scholar
PubMed Close
,
Zhengyuan Wang Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Zhengyuan Wang in
Google Scholar
PubMed Close
,
Ping Liao Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Ping Liao in
Google Scholar
PubMed Close
,
Tong Liu Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Tong Liu in
Google Scholar
PubMed Close
,
Zehuan Shi Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Zehuan Shi in
Google Scholar
PubMed Close
,
Qi Song Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Qi Song in
Google Scholar
PubMed Close
,
Xueying Cui Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Xueying Cui in
Google Scholar
PubMed Close
,
Wenjing Wang Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Wenjing Wang in
Google Scholar
PubMed Close
, and
Jiajie Zang Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

Search for other papers by Jiajie Zang in
Google Scholar
PubMed Close

adulthood ( 2 , 5 , 6 ). Thyroid hormones can regulate metabolism associated with basal metabolic rate and body composition ( 7 , 8 ). In general, the thyroid-stimulating hormone (TSH) is positively correlated with BMI, whereas total thyroxine (TT4) and

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0599
Volume/Issue:
Volume 11: Issue 4
Open access
Kusum Lata Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Kusum Lata in
Google Scholar
PubMed Close
,
Pinaki Dutta Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Pinaki Dutta in
Google Scholar
PubMed Close
,
Subbiah Sridhar Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Subbiah Sridhar in
Google Scholar
PubMed Close
,
Minakshi Rohilla Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Minakshi Rohilla in
Google Scholar
PubMed Close
,
Anand Srinivasan Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Anand Srinivasan in
Google Scholar
PubMed Close
,
G R V Prashad Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by G R V Prashad in
Google Scholar
PubMed Close
,
Viral N Shah Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Viral N Shah in
Google Scholar
PubMed Close
, and
Anil Bhansali Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Search for other papers by Anil Bhansali in
Google Scholar
PubMed Close

vacutainers at the initial visit. Each blood sample was analysed for TSH, free tri-iodothyronine (FT 3 ), free T 4 (FT 4 ) and anti-TPO by electro-chemiluminescence immunoassay (ELECSYS-2010, Roche–Hitachi Diagnostics). The reference range for the above

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0012
Volume/Issue:
Volume 2: Issue 2
Open access
Nella Augusta Greggio Endocrinology and Adolescence Unit, Department of Woman and Child Health, University of Padova, Padova, Italy

Search for other papers by Nella Augusta Greggio in
Google Scholar
PubMed Close
,
Elisa Rossi CINECA – Interuniversity Consortium (Health Service), Bologna, Italy

Search for other papers by Elisa Rossi in
Google Scholar
PubMed Close
,
Silvia Calabria CORE srl – Collaborative Outcome Research, Bologna, Italy

Search for other papers by Silvia Calabria in
Google Scholar
PubMed Close
,
Alice Meneghin Endocrinology and Adolescence Unit, Department of Woman and Child Health, University of Padova, Padova, Italy

Search for other papers by Alice Meneghin in
Google Scholar
PubMed Close
,
Joaquin Gutierrez de Rubalcava Endocrinology and Adolescence Unit, Department of Woman and Child Health, University of Padova, Padova, Italy

Search for other papers by Joaquin Gutierrez de Rubalcava in
Google Scholar
PubMed Close
,
Carlo Piccinni CORE srl – Collaborative Outcome Research, Bologna, Italy

Search for other papers by Carlo Piccinni in
Google Scholar
PubMed Close
, and
Antonella Pedrini CORE srl – Collaborative Outcome Research, Bologna, Italy

Search for other papers by Antonella Pedrini in
Google Scholar
PubMed Close

Introduction Subclinical hypothyroidism (SH) is a biochemical condition defined as serum thyroid-stimulating hormone (TSH) exceeding the limit of its reference range by age, while the concentration of serum free thyroxin (FT4) remains within

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0066
Volume/Issue:
Volume 6: Issue 6
Open access
Marcus Heldmann Department of Neurology, University of Lübeck, Lübeck, Germany
Department of Psychology II, University of Lübeck, Lübeck, Germany

Search for other papers by Marcus Heldmann in
Google Scholar
PubMed Close
,
Krishna Chatterjee Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK

Search for other papers by Krishna Chatterjee in
Google Scholar
PubMed Close
,
Carla Moran Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK

Search for other papers by Carla Moran in
Google Scholar
PubMed Close
,
Berenike Rogge Department of Neurology, University of Lübeck, Lübeck, Germany

Search for other papers by Berenike Rogge in
Google Scholar
PubMed Close
,
Julia Steinhardt Department of Neurology, University of Lübeck, Lübeck, Germany

Search for other papers by Julia Steinhardt in
Google Scholar
PubMed Close
,
Tobias Wagner-Altendorf Department of Neurology, University of Lübeck, Lübeck, Germany

Search for other papers by Tobias Wagner-Altendorf in
Google Scholar
PubMed Close
,
Martin Göttlich Department of Neurology, University of Lübeck, Lübeck, Germany

Search for other papers by Martin Göttlich in
Google Scholar
PubMed Close
,
Hannes Schacht Department of Neuroradiology, University of Lübeck, Lübeck, Germany

Search for other papers by Hannes Schacht in
Google Scholar
PubMed Close
,
Peter Schramm Department of Neuroradiology, University of Lübeck, Lübeck, Germany

Search for other papers by Peter Schramm in
Google Scholar
PubMed Close
,
Georg Brabant Department of Internal Medicine I, University of Lübeck, Lübeck, Germany
Department of Endocrinology, The Christie, University of Manchester, Manchester, UK

Search for other papers by Georg Brabant in
Google Scholar
PubMed Close
,
Thomas F Münte Department of Neurology, University of Lübeck, Lübeck, Germany
Department of Psychology II, University of Lübeck, Lübeck, Germany

Search for other papers by Thomas F Münte in
Google Scholar
PubMed Close
, and
Anna Cirkel Department of Neurology, University of Lübeck, Lübeck, Germany

Search for other papers by Anna Cirkel in
Google Scholar
PubMed Close

determination of TSH, which is generally normal, or slightly elevated in some cases. However, free thyroxine (fT4) is universally elevated ( 4 ). In RTHβ, the sensitivity of the hypothalamic–pituitary axis to thyroid hormone is reduced, due to altered signalling

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-21-0473
Volume/Issue:
Volume 11: Issue 1
Open access
Qian Yang Q Yang, Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China

Search for other papers by Qian Yang in
Google Scholar
PubMed Close
,
Qiannan Zhang Q Zhang, shanghai, China

Search for other papers by Qiannan Zhang in
Google Scholar
PubMed Close
,
Fanfan Pan F Pan, Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Shanghai, 200240, China

Search for other papers by Fanfan Pan in
Google Scholar
PubMed Close
, and
Bingbing Zha B Zha, shanghai, 200240, China

Search for other papers by Bingbing Zha in
Google Scholar
PubMed Close

Background: Signal transducer and activator of transcription 6 (STAT6) is an important nuclear transcription factor. Previous study demonstrated that blockading STAT6 can ameliorate thyroid function by reducing serum T3 and T4. Sodium/iodide symporter (NIS) is a key protein that mediates active iodine uptake and plays an important role in regulating thyroid function. This study explored the interaction between STAT6 and NIS.

Methods: Immunohistochemical staining was performed for detecting the expression of NIS in different tissues. Reverse transcription-polymerase chain reaction (RT-PCR) was performed for evaluating the mRNA level of NIS when Nthy-ori 3-1cells were incubated with IL4, TSH (Thyroid stimulating hormone) or monoclonal TSAb (thyroid-specific stimulatory autoantibody) for 24h. Quantitative RT-PCR,Western blot and immunofluorescence analysis were performed for detecting NIS expression after inhibiting STAT6 phosphorylation by AS1517499. Finally, we used Luciferase reporter assays to explore the ability of STAT6 to regulate the promoter activity of the NIS-coding gene.

Results: NIS was highly expressed in thyroid epithelial cells of EAGD mice or Graves' disease (GD) patients and TSAb increased the expression of NIS. We show that STAT6 phosphorylation inhibitor can attenuate the effect of TSAb on increasing NIS protein and mRNA levels. Finally, we confirm that transcription factor STAT6 can mediate NIS transcription and co-activator P100 protein can enhance STAT6-dependent transcriptional activation.

Conclusion: In Graves' disease, TSAb induces STAT6 signaling to upregulate NIS expression and STAT6 blockade ameliorates thyroid function via downregulation of the sodium/iodide symporter. Our study furthers understanding of the effects of STAT6 on thyroid function and reveals new avenues for GD treatment.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-24-0428
Volume/Issue:
Accepted Manuscripts
Open access
Isabel M Abreu Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal

Search for other papers by Isabel M Abreu in
Google Scholar
PubMed Close
,
Eva Lau Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar S. João, Alameda Professor Hernâni Monteiro, Porto, Portugal
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

Search for other papers by Eva Lau in
Google Scholar
PubMed Close
,
Bernardo de Sousa Pinto Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal

Search for other papers by Bernardo de Sousa Pinto in
Google Scholar
PubMed Close
, and
Davide Carvalho Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar S. João, Alameda Professor Hernâni Monteiro, Porto, Portugal
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

Search for other papers by Davide Carvalho in
Google Scholar
PubMed Close

Introduction Subclinical hypothyroidism (SCH) is diagnosed biochemically when both serum-free thyroxine (FT4) and free triiodothyronine (FT3) are within the normal range, whereas the serum thyroid-stimulating hormone (TSH) is elevated ( 1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0028
Volume/Issue:
Volume 6: Issue 3
Open access
Signe Kirkegaard Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

Search for other papers by Signe Kirkegaard in
Google Scholar
PubMed Close
,
Nanna Maria Uldall Torp Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

Search for other papers by Nanna Maria Uldall Torp in
Google Scholar
PubMed Close
,
Stig Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark

Search for other papers by Stig Andersen in
Google Scholar
PubMed Close
, and
Stine Linding Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

Search for other papers by Stine Linding Andersen in
Google Scholar
PubMed Close

hypothyroidism seen as part of Hashimoto’s thyroiditis (HT) ( 2 ). In GD, antibodies against the thyroid-stimulating hormone (TSH) receptor (TRAb) stimulate the thyroid gland to an increased production of thyroid hormone that causes the biochemical

Article Type:
Review Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-23-0431
Volume/Issue:
Volume 13: Issue 2
Open access