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Yanling Cai Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Yan Yang Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Xiao Pang Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Suping Li Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Introduction Thyroid cancer (TC) is the most common endocrine tumor, and its global incidence is increasing annually; however, the global incidence among females is 10.1 per 100,000, which is three times higher than the incidence among males

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Kim Magaly Pabst Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Robert Seifert Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

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Nader Hirmas Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Martina Broecker-Preuss Department of Medicine, Ruhr-University Bochum, University Hospital, Knappschaftskrankenhaus Bochum, Bochum, Germany

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Manuel Weber Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Wolfgang Peter Fendler Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Timo Bartel Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Sarah Theurer German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Ken Herrmann Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Rainer Görges Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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over a period of >10 years. Conclusion U-hsTg measurement in patients with differentiated thyroid cancer within 24 months after completing radioiodine therapy showed higher predictive power than s-Tg measurement for RFS for a time period >10

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Mahmoud Al-Masri Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Tawfiq Al-Shobaki Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Hani Al-Najjar Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Rafal Iskanderian Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Enas Younis Department of Internal Medicine, Endocrine, King Hussein Cancer Center, Amman, Jordan

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Niveen Abdallah Department of Cell Therapy & Applied Genomics, King Hussein Cancer Center, Amman, Jordan

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Abdelghani Tbakhi Department of Cell Therapy & Applied Genomics, King Hussein Cancer Center, Amman, Jordan

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Hussam Haddad Department of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan

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Mohammad Al-Masri School of Medicine, University of Jordan, Amman, Jordan

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Zeinab Obeid Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Awad Jarrar Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Introduction Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer accounting for approximately 85–88% of cases. The incidence of PTC is rapidly increasing, in contrast to other subtypes ( 1 ). The increase in the

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Thomas Crezee Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

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Mirela Petrulea Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

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Doina Piciu Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Martin Jaeger Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
Department of Nuclear Medicine and Endocrine Tumors, Institute of Oncology ‘Prof. Dr. Ion Chiricuta’, Cluj-Napoca, Romania

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Jan W A Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Theo S Plantinga Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
Department of Nuclear Medicine and Endocrine Tumors, Institute of Oncology ‘Prof. Dr. Ion Chiricuta’, Cluj-Napoca, Romania

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Carmen E Georgescu Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Endocrinology Clinic, Cluj County Emergency Hospital, Cluj-Napoca, Romania

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Romana Netea-Maier Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
Department of Nuclear Medicine and Endocrine Tumors, Institute of Oncology ‘Prof. Dr. Ion Chiricuta’, Cluj-Napoca, Romania

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Background In recent years, the incidence of non-medullary thyroid cancer (NMTC) has steadily increased ( 1 , 2 , 3 , 4 ). Although most NMTC patients have a favorable prognosis, 20–30% of patients with locally advanced or metastatic

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Jes Sloth Mathiesen Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Jens Peter Kroustrup Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Peter Vestergaard Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Kirstine Stochholm Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Center for Rare Diseases, Aarhus University Hospital, Aarhus N, Denmark

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Per Løgstrup Poulsen Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Sten Schytte Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Stefano Christian Londero Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Henrik Baymler Pedersen Department of ORL Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark

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Christoffer Holst Hahn Department of ORL Head & Neck Surgery, Copenhagen University Hospital, Copenhagen, Denmark

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Bjarki Ditlev Djurhuus Department of ORL Head & Neck Surgery, Zealand University Hospital, Køge, Denmark

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Jens Bentzen Department of Oncology, Herlev Hospital, Herlev, Denmark

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Sören Möller Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark

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Mette Gaustadnes Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Maria Rossing Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Finn Cilius Nielsen Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Kim Brixen Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Anja Lisbeth Frederiksen Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

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Christian Godballe Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark

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the Danish Thyroid Cancer Group (DATHYRCA)
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/17801). Methods The MTC cohort was based on the Danish Cancer Registry, the Danish Pathology Register and the Danish Thyroid Cancer Database, which have prospectively collected data since 1943, 1968 and 1996, respectively. The first year, in which registration

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Hanrong Zhang H Zhang, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Junxin Chen J Chen, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Xin Chen X Chen, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Chuimian Zeng C Zeng, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Pengyuan Zhang P Zhang, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Jiewen Jin J Jin, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Haipeng Xiao H Xiao, Endocrinology, The first affiliated hospital of Sun Yat-sen University, Guangzhou, China

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Yanbing Li Y Li, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guanzhou, China

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Hongyu Guan H Guan, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Hai Li H Li, Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Background: Transforming growth factor beta receptor III (TGFBR3) has been shown to play a tumor suppressive role in a variety of cancers. However, its role in papillary thyroid cancer (PTC) remains unknown.

Method: TGFBR3 expression levels in PTC were analyzed utilizing TCGA and GEO database. Edu, wounding healing and Transwell assays were used to evaluate cell proliferation, migration and invasion. Transcriptome sequencing, qRT-PCR and Western blotting were used to detect the underlying mechanism of TGFBR3 in PTC progression.

Result: This study demonstrated that TGFBR3 expression was significantly down-regulated in PTC compared to normal thyroid tissues. Low expression of TGFBR3 was associated with poor prognosis of patients with PTC. Furthermore, TGFBR3 expression positively correlated with thyroid differentiation score. In investigating the biological impact of TGFBR3 over-expression in PTC cell lines, we found that the proliferation, migration and invasion of PTC cells were significantly inhibited in response to TGFBR3 overexpression. Moreover, we also demonstrated that overexpression of TGFBR3 inhibited PI3K/AKT pathway and epithelial mesenchymal transformation processes. Lastly, TGFBR3 expression was found to be involved in tumor immune infiltration, highlighting its potential influence on immune dynamics within the tumor microenvironment in PTC.

Conclusion: TGFBR3 plays a tumor suppressive role in PTC progression by inhibiting PI3K/AKT pathway and EMT.

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Weiwei Liang W Liang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Junxin Chen J Chen, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guang Zhou, China

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Hai Li H Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Pengyuan Zhang P Zhang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Hongyu Guan H Guan, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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Yanbing Li Y Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guanzhou, China

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Background: Collagen type VIII α 1 chain (COL8A1), a collagen type VIII protein, has been suggested to exert various functions in progression of multiple cancers. However, the effect of COL8A1 in papillary thyroid cancer (PTC) has not been elucidated.

Methods: The Cancer Genome Atlas (TCGA) databases were applied to investigate the COL8A1 expression and its clinical significance in PTC. The COL8A1 expression level was further validated using Gene Expression Omnibus (GEO) data and clinical paired PTC tissues. Additionally, Kaplan-Meier curve was used to analyze the prognosis. The cell migrative and invasive abilities were evaluated by wound healing assay and Transwell assay. CCK8 assays were used to evaluate proliferation of PTC cells. Western blotting was conducted to explore the potential mechanisms involved in the pro-tumor role of COL8A1. The correlation between immune cell infiltration and COL8A1 was analyzed using Tumor Immune Estimation Resource (TIMER) database and the single-sample GSEA (ssGSEA) method.

Results: We found that COL8A1 was upregulated in PTC (P<0.05). High COL8A1 expression level was significantly associated with advanced T stage (P<0.01), N stage (P<0.001) and poor prognosis (P=0.0142) in PTC. Furthermore, cell migration and invasion were significantly reduced following COL8A1 knockdown (P<0.001). Mechanistic studies demonstrated that the epithelial-to-mesenchymal transition (EMT) related proteins (FN1, MMP9, MMP7, ZEB2 and Twist1) and phosphorylation of AKT and ERK were obviously down-regulated after COL8A1 knockdown (P<0.01). Moreover, COL8A1 expression was correlated with immune cell infiltration.

Conclusion: Our study demonstrates that COL8A1 may function as an oncogene and a potential prognostic biomarker for PTC patients.

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Norra Kwong Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Ellen Marqusee Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Michael S Gordon Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA
Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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P Reed Larsen Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Jeffrey R Garber Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA
Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Matthew I Kim Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Erik K Alexander Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Introduction Well-differentiated thyroid cancer is common, easily identified, and often curable. While the incidence of thyroid cancer has nearly tripled in the past three decades, mortality rates have remained stable (1, 2, 3) . This underscores

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Teresa Kraus Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Natalia Shengelia-de Lange Division of Nuclear Medicine, Tbilisi State Medical University, Tbilisi, Georgia

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Holger Einspieler Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Marcus Hacker Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Alexander Haug Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Elisabeth Kretschmer-Chott Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Georgios Karanikas Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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this article). There was no statistically significant difference between the TNM staging in patients from Vienna and Tbilisi. The distribution of histotype showed 345 patients with papillary thyroid cancer (PTC) (93%) and 25 patients with follicular

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Rui M B Maciel Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Cleber P Camacho Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Lígia V M Assumpção Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil

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Natassia E Bufalo Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil

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André L Carvalho Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil

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Gisah A de Carvalho Faculdade de Medicina, Universidade Federal do Paraná, Curitiba, Paraná, Brazil

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Luciana A Castroneves Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil

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Francisco M de Castro Jr Universidade Federal do Ceará, Fortaleza, Ceará, Brazil

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Lucieli Ceolin Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Janete M Cerutti Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Rossana Corbo Instituto Nacional do Câncer, Rio de Janeiro, Rio de Janeiro, Brazil

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Tânia M B L Ferraz Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil

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Carla V Ferreira Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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M Inez C França Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil
Hospital Santa Rita de Cássia, Vitória, Espírito Santo, Brazil

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Henrique C R Galvão Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil

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Fausto Germano-Neto Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Hans Graf Faculdade de Medicina, Universidade Federal do Paraná, Curitiba, Paraná, Brazil

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Alexander A L Jorge Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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Ilda S Kunii Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Márcio W Lauria Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Vera L G Leal Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, Rio de Janeiro, Brazil

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Susan C Lindsey Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Delmar M Lourenço Jr Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil

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Léa M Z Maciel Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

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Patrícia K R Magalhães Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

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João R M Martins Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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M Cecília Martins-Costa Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil
Universidade de Fortaleza, Fortaleza, Ceará, Brazil

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Gláucia M F S Mazeto Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil

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Anelise I Impellizzeri Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Célia R Nogueira Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil

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Edenir I Palmero Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil
Faculdade de Ciências da Saúde de Barretos Dr. Paulo Prata, Barretos, São Paulo, Brazil

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Cencita H C N Pessoa Instituto Nacional do Câncer, Rio de Janeiro, Rio de Janeiro, Brazil

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Bibiana Prada Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil

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Débora R Siqueira Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Maria Sharmila A Sousa Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
Escola Fiocruz de Governo, Fundação Oswaldo Cruz and Ministério da Saúde, Brasília, Distrito Federal, Brazil

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Rodrigo A Toledo Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Vall d’Hebron Institute of Oncology (VHIO), CIBERONC, Barcelona, Spain

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Flávia O F Valente Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Fernanda Vaisman Instituto Nacional do Câncer, Rio de Janeiro, Rio de Janeiro, Brazil

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Laura S Ward Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil

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Shana S Weber Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Rita V Weiss Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, Rio de Janeiro, Brazil

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Ji H Yang Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Magnus R Dias-da-Silva Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Ana O Hoff Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil
Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo, Brazil

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Sergio P A Toledo Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil
Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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Ana L Maia Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Brazilian centers involved in the diagnosis and treatment of thyroid cancer. Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported

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