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the large short-chain dehydrogenase/reductase (SDR) family of enzymes that are NAD + or NADP + dependent oxidoreductases, typically 250–350 amino acids in length ( 3 ). SDR enzymes have a wide range of substrates including steroids, aromatic
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), respectively. Increased levels of ACTH are not only unable to compensate for the deficient cortisol synthesis, but their trophic effects also produce adrenal gland enlargement ( 2 ). Pathologically, CAH is mainly caused by an inborn error of steroid synthesis
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the test groups with highest fatty acid concentrations. Steroid hormone estimation Concentrations of 17β-estradiol (E2) and progesterone (P4) in the conditioned media were determined by competitive 3H radioimmunoassay (RIA) with rabbit
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Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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levels). Women using hormonal preparations and medications affecting glucose metabolism and steroid synthesis were excluded from the study. Alternatively, a washout period of 2 months was required for women using hormonal preparations before participating
Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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. The participants who had received steroids any time after the discharge were further excluded from the follow-up visits. In the final analysis, 90 patients were available for follow-up at 12 months ( Fig. 1 ). They were assessed for clinical
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Estradiol (E2) and dihydrotestosterone (DHT). Finally, T concentration depends on the clearance rate, determined by, conversion of T to its metabolites, conjugation capacity, as well as urinary excretion. The ability of excreting T and other steroids in the
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knowledgebase. The results revealed several significantly altered metabolic pathways ( P < 0.05) in the plasma of DCM patients. The metabolic pathways that showed significant differences in DCM plasma included steroid hormone biosynthesis, purine metabolism
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which primary adrenal insufficiency (PAI) and steroid-resistant nephrotic syndrome (SRNS) necessitating renal transplantation predominate ( 1 , 2 , 3 , 4 ). Additional clinical features including ichthyosis, progressive neurological disease, primary
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(panhypophysitis)) AND ((steroid) OR (glucocorticoid) OR (corticoids) OR (predniso*) OR (corticoster*) OR (methylprednisolone) OR (conservatively) OR (conservative))’ as keywords with ‘humans’ and ‘English’ language filters. We further manually reviewed the
School of Women’s & Children’s Health, Discipline of Obstetrics and Gynaecology, University of New South Wales, Sydney, Australia
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). The key ovarian factors believed responsible are the steroids, oestradiol and progesterone, and the protein hormones, inhibin A and B. However, their respective roles are not clearly understood. In a previous study (( 2 ), and ( 3 ) designated in