A Daniel Bird
A Daniel Bird
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
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Spencer Greatorex
Spencer Greatorex
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
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David Reser
David Reser
Department of Physiology, Monash University, Melbourne, Victoria, Australia
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Gareth G Lavery
Gareth G Lavery
Institute of Metabolism and Systems Research, 2nd Floor IBR Tower, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Timothy J Cole
Timothy J Cole
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
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the large short-chain dehydrogenase/reductase (SDR) family of enzymes that are NAD + or NADP + dependent oxidoreductases, typically 250–350 amino acids in length ( 3 ). SDR enzymes have a wide range of substrates including steroids, aromatic
Qiuli Liu
Qiuli Liu
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Lin-ang Wang
Lin-ang Wang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Jian Su
Jian Su
Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medical, Nanjing, People’s Republic of China
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Dali Tong
Dali Tong
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Weihua Lan
Weihua Lan
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Luofu Wang
Luofu Wang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Gaolei Liu
Gaolei Liu
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Jun Zhang
Jun Zhang
Department of Obstetrics, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China
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Victor Wei Zhang
Victor Wei Zhang
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
AmCare Genomics Lab, Guangzhou, People’s Republic of China
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AmCare Genomics Lab, Guangzhou, People’s Republic of China
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Dianzheng Zhang
Dianzheng Zhang
Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA
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Rongrong Chen
Rongrong Chen
Geneplus-Beijing Institute, Beijing, People’s Republic of China
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Qingyi Zhu
Qingyi Zhu
Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medical, Nanjing, People’s Republic of China
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Jun Jiang
Jun Jiang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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), respectively. Increased levels of ACTH are not only unable to compensate for the deficient cortisol synthesis, but their trophic effects also produce adrenal gland enlargement ( 2 ). Pathologically, CAH is mainly caused by an inborn error of steroid synthesis
Arpna Sharma
Arpna Sharma
Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
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Vijay Simha Baddela
Vijay Simha Baddela
Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
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Frank Becker
Frank Becker
Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
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Dirk Dannenberger
Dirk Dannenberger
Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
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Torsten Viergutz
Torsten Viergutz
Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
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Jens Vanselow
Jens Vanselow
Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
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the test groups with highest fatty acid concentrations. Steroid hormone estimation Concentrations of 17β-estradiol (E2) and progesterone (P4) in the conditioned media were determined by competitive 3H radioimmunoassay (RIA) with rabbit
Shilpa Lingaiah
Shilpa Lingaiah
Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland
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Laure Morin-Papunen
Laure Morin-Papunen
Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland
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Terhi Piltonen
Terhi Piltonen
Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland
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Inger Sundström-Poromaa
Inger Sundström-Poromaa
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
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Elisabet Stener-Victorin
Elisabet Stener-Victorin
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Juha S Tapanainen
Juha S Tapanainen
Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland
Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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levels). Women using hormonal preparations and medications affecting glucose metabolism and steroid synthesis were excluded from the study. Alternatively, a washout period of 2 months was required for women using hormonal preparations before participating
Saroj Kumar Sahoo
Saroj Kumar Sahoo
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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Jayakrishnan C Menon
Jayakrishnan C Menon
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Nidhi Tripathy
Nidhi Tripathy
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Monalisa Nayak
Monalisa Nayak
Department of Liver Intensive Care Unit, King’s College Hospital, London, UK
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Subhash Yadav
Subhash Yadav
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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. The participants who had received steroids any time after the discharge were further excluded from the follow-up visits. In the final analysis, 90 patients were available for follow-up at 12 months ( Fig. 1 ). They were assessed for clinical
Annette Mouritsen
Annette Mouritsen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Alexander Siegfried Busch
Alexander Siegfried Busch
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Lise Aksglaede
Lise Aksglaede
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Ewa Rajpert-De Meyts
Ewa Rajpert-De Meyts
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Estradiol (E2) and dihydrotestosterone (DHT). Finally, T concentration depends on the clearance rate, determined by, conversion of T to its metabolites, conjugation capacity, as well as urinary excretion. The ability of excreting T and other steroids in the
Run-Qing Xiong
Run-Qing Xiong
Department of Ultrasonic Imaging, Xiamen Medical College Affiliated Second Hospital, Fujian, China
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Yan-Ping Li
Yan-Ping Li
Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Fujian, China
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Lu-Ping Lin
Lu-Ping Lin
Department of Endocrinology, Xiamen Medical College Affiliated Second Hospital, Fujian, China
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Jeng-Yuan Yao
Jeng-Yuan Yao
Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Fujian, China
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knowledgebase. The results revealed several significantly altered metabolic pathways ( P < 0.05) in the plasma of DCM patients. The metabolic pathways that showed significant differences in DCM plasma included steroid hormone biosynthesis, purine metabolism
Avinaash Maharaj
Avinaash Maharaj
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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Ruth Kwong
Ruth Kwong
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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Jack Williams
Jack Williams
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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Christopher Smith
Christopher Smith
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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Helen Storr
Helen Storr
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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Ruth Krone
Ruth Krone
Birmingham Children’s Hospital, Birmingham, UK
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Debora Braslavsky
Debora Braslavsky
Centro de Investigaciones Endocrinológicas ‘Dr. Cesar Bergadá’ (CEDIE) – CONICET – FEI – División de Endocrinología, Hospital de Niños ‘Ricardo Gutiérrez’, Buenos Aires, Argentina
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Maria Clemente
Maria Clemente
Paediatric Endocrinology, Growth and Development Research Unit, Vall d’Hebron Research Institute (VHIR), Hospital Vall d’Hebron, CIBERER, Instituto de Salud Carlos III, Barcelona, Spain
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Nanik Ram
Nanik Ram
Department of Endocrinology, The Aga Khan University Hospital, Karachi, Pakistan
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Indraneel Banerjee
Indraneel Banerjee
Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Manchester, UK
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Semra Çetinkaya
Semra Çetinkaya
Health Sciences University, Dr. Sami Ulus Obstetrics and Gynaecology, Children’s Health and Disease Education and Research Hospital, Ankara, Turkey
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Federica Buonocore
Federica Buonocore
Genetics and Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
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Tülay Güran
Tülay Güran
Department of Paediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul, Turkey
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John C Achermann
John C Achermann
Genetics and Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
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Louise Metherell
Louise Metherell
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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Rathi Prasad
Rathi Prasad
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, London, UK
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which primary adrenal insufficiency (PAI) and steroid-resistant nephrotic syndrome (SRNS) necessitating renal transplantation predominate ( 1 , 2 , 3 , 4 ). Additional clinical features including ichthyosis, progressive neurological disease, primary
Brijesh Krishnappa
Brijesh Krishnappa
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Ravikumar Shah
Ravikumar Shah
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Saba Samad Memon
Saba Samad Memon
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Chakra Diwaker
Chakra Diwaker
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Anurag R Lila
Anurag R Lila
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Virendra A Patil
Virendra A Patil
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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Tushar R Bandgar
Tushar R Bandgar
Department of Endocrinology, K E M Hospital and Seth G S Medical College, Mumbai, India
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(panhypophysitis)) AND ((steroid) OR (glucocorticoid) OR (corticoids) OR (predniso*) OR (corticoster*) OR (methylprednisolone) OR (conservatively) OR (conservative))’ as keywords with ‘humans’ and ‘English’ language filters. We further manually reviewed the
David Mark Robertson
David Mark Robertson
Department of Molecular and Translational Sciences, Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australia
School of Women’s & Children’s Health, Discipline of Obstetrics and Gynaecology, University of New South Wales, Sydney, Australia
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School of Women’s & Children’s Health, Discipline of Obstetrics and Gynaecology, University of New South Wales, Sydney, Australia
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Chel Hee Lee
Chel Hee Lee
Clinical Research Support Unit, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
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Angela Baerwald
Angela Baerwald
Department of Obstetrics, Gynecology & Reproductive Sciences, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
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). The key ovarian factors believed responsible are the steroids, oestradiol and progesterone, and the protein hormones, inhibin A and B. However, their respective roles are not clearly understood. In a previous study (( 2 ), and ( 3 ) designated in
