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Heleen I Jansen Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands

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Marijn M Bult Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands

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Peter H Bisschop Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands

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Anita Boelen Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Annemieke C Heijboer Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Jacquelien J Hillebrand Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands

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the immunometric ECLIA assay (Gen I) on the Cobas e601 platform (Roche, reference interval 0.5–5.0 mU/L). Multilevel internal quality controls (Randox Immuno L1 and L2) were measured daily. The laboratory participated in the Dutch external quality

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0538
Volume/Issue:
Volume 12: Issue 4
Open access
Waleed K W Al-Badri Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands

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Hinke Marijke Jellema Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands

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Arnaud R G G Potvin Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands

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Ruth M A van Nispen Amsterdam University Medical Center, Vrije Universiteit, Department of Ophthalmology, Amsterdam Public Health research institute, Amsterdam, the Netherlands

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Peter H Bisschop Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands

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Peerooz Saeed Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands

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eyelid retraction, diplopia, and even corneal ulceration and optic neuropathy ( 1 ). All these clinical manifestations make GO a vision-threatening and disfiguring illness, heavily affecting the quality of life (QoL) and mental well-being of patients. GO

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0259
Volume/Issue:
Volume 13: Issue 9
Open access
Lukas Engler Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Christian Adolf Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Daniel A Heinrich Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Anna-Katharine Brem Max-Planck-Institute of Psychiatry, Munich, Germany
Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

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Anna Riester Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Anna Franke Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Felix Beuschlein Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Martin Reincke Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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Axel Steiger Max-Planck-Institute of Psychiatry, Munich, Germany

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Heike Künzel Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany

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affected than males ( 1 ). These patients were also found to have a lower quality of life (QoL) even after treatment with either a mineralocorticoid receptor (MR) antagonist or adrenalectomy (ADX) ( 2 ). Cognitive deficits are prevalent in depression ( 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0043
Volume/Issue:
Volume 8: Issue 4
Open access
Guillem Cuatrecasas Endocrinology Department, Hospital Quiron-Teknon, CPEN S.L., Barcelona, Spain
Universitat Oberta Catalunya (UOC), Barcelona, Spain

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Hatice Kumru Institut Guttmann, Institut Universitari de Neurorehabilitació Adscrit a la UAB, Barcelona, Spain
Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain

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M Josep Coves Endocrinology Department, Hospital Quiron-Teknon, CPEN S.L., Barcelona, Spain

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Joan Vidal Institut Guttmann, Institut Universitari de Neurorehabilitació Adscrit a la UAB, Barcelona, Spain
Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain

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Cord Impact measurement) to evaluate the quality of live and functional recovery ( 19 ), modified Ashworth scales for spasticity ( 20 ) and neurophysiological tests (Motor (MEPs) and somatosensory evoked potentials (SEPs) to evaluate motor and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0296
Volume/Issue:
Volume 7: Issue 10
Open access
Darling M Rojas-Canales The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Michaela Waibel Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
The University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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Aurelien Forget Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia

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Daniella Penko The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Jodie Nitschke The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Fran J Harding Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia

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Bahman Delalat Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia

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Anton Blencowe Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Thomas Loudovaris Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia

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Shane T Grey The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Helen E Thomas Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
The University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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Thomas W H Kay Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
The University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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Chris J Drogemuller The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Nicolas H Voelcker Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

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Patrick T Coates The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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are required to measure blood glucose levels and inject insulin multiple times per day and often experience severe impairment of quality of life and potential long-term effects such as microvascular complications and organ damage ( 4 , 5 , 6 , 7

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0349
Volume/Issue:
Volume 7: Issue 3
Open access
S Westra Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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Y H M Krul-Poel Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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H J van Wijland Department of General Practice, DIAZON, Alkmaar, the Netherlands

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M M ter Wee Department of Epidemiology and Biostatistics, VU Medical Centre, Amsterdam, the Netherlands

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F Stam Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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P Lips Department of Internal Medicine, Endocrine Section, VU Medical Centre, Amsterdam, the Netherlands

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F Pouwer Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands

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S Simsek Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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prevalences of depression, fatigue and (neuropathic) pain were found resulting in a decreased quality of life ( 2 , 3 , 4 , 5 , 6 ). Depressive symptoms and fatigue in people with diabetes are related to an increased risk of developing diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0070
Volume/Issue:
Volume 5: Issue 6
Open access
Ann-Cathrin Koschker Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany

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Bodo Warrings Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany

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Caroline Morbach Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Florian Seyfried Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany

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Nicole Rickert Department of Radiology, University Hospital, University of Würzburg, Würzburg, Germany

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Pius Jung Division of Pneumology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Andreas Geier Division of Hepatology, Department of Internal Medicine II, University Hospital, University of Würzburg, Würzburg, Germany

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Ulrich Dischinger Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Maike Krauthausen Department of General Practice, University Hospital, University of Würzburg, Würzburg, Germany

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Martin J Herrmann Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany

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Christine Stier Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany

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Stefan Frantz Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Uwe Malzahn Center for Clinical Trials, University Hospital, University of Würzburg, Würzburg, Germany

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Stefan Störk Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Martin Fassnacht Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany

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the WAS Study Group
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the WAS Study Group

regulation, exercise capacity, hemodynamic parameters, cardiac remodeling, and the quality of life (QoL). However, the evidence base explaining the influence of weight loss surgery on the heart remains poorly defined and mainly relies on non

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-21-0338
Volume/Issue:
Volume 11: Issue 2
Open access
Ann-Kristin Picke Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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Graeme Campbell Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany

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Nicola Napoli Diabetes and Bone Network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy
Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA

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Lorenz C Hofbauer Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Martina Rauner Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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progenitor cells (EPC) is reduced in T2DM leading to vessel permeability. In addition, T2DM causes microhypoxia in bone niche, which in turn increases inflammation. (7) T2DM patients have an increased risk of falls and fractures due to reduced bone quality

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0456
Volume/Issue:
Volume 8: Issue 3
Open access
Hei Yi Vivian Pak Department of Neurosurgery, University Hospital of Wales, Cardiff, UK
Cardiff University School of Medicine, Cardiff, UK

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Andrew Lansdown Centre for Diabetes and Endocrinology, University Hospital of Wales, Cardiff, UK

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Peter Taylor Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK
Centre for Diabetes and Endocrinology, University Hospital of Wales, Cardiff, UK

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Dafydd Aled Rees Centre for Diabetes and Endocrinology, University Hospital of Wales, Cardiff, UK
Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK

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John Stephen Davies Centre for Diabetes and Endocrinology, University Hospital of Wales, Cardiff, UK

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Caroline Hayhurst Department of Neurosurgery, University Hospital of Wales, Cardiff, UK
Cardiff University School of Medicine, Cardiff, UK

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problems, with a significant impact on both quality of life and life expectancy ( 4 , 5 ). Additionally, the diagnostic delay often shapes patients’ attitudes to health care professionals, which impacts on the quality of communication and subsequent

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0335
Volume/Issue:
Volume 9: Issue 10
Open access
Rong Xu Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Difei Lian Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yan Xie Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Lin Mu Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yali Wu Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Zhilei Chen Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Baoyu Zhang Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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by inhibiting bone formation by osteoblasts while promoting bone resorption by osteoclasts, finally leading to joint deformity and seriously affecting the quality of life ( 5 , 7 , 9 , 10 ). Besides, it has been reported that UA can inhibit the

Article Type:
Review Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-23-0040
Volume/Issue:
Volume 12: Issue 11
Open access