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National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
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. ISS of known etiology (A) Disproportionate (1) Congenital: skeletal dysplasias (2) Acquired: secondary to malformations, radiotherapy, tumors, and other diseases (B) Proportionate of prenatal origin (newborn SGA
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influence during early development (i.e. preconceptional up to 1000 days of postnatal life) can program the unborn/newborn for metabolic dysfunctions later in life. Apart from environmental factors maternal diseases such as overweight or excessive weight
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combination of pneumococcal vaccine, universal screening of the newborn, early penicillin prophylaxis and hydroxyurea treatment has greatly extended the life span of these children as well as noted that their growth and pubertal maturation has increased but
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Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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age of the tissue, the cells are obtained from. Newborn samples show the highest secretion potential ( 141 ) 12–36 7 Cadaveric testes Primary Sertoli cell cultures Phenotypic characteristics and functionality of primary human Sertoli
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Jan van Goyen Medical Center, Department of Internal Medicine, Amsterdam, the Netherlands
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Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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phenotype such as a history of fractures before pregnancy and severely reduced BMD (Z-score < −2.0 s.d. ). This is especially critical in cases in which BMD does not recover in the months after pregnancy and/or weaning ( 79 ). Screening for an underlying