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María L Bacigalupo Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Verónica G Piazza Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Nadia S Cicconi Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Pablo Carabias Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Andrzej Bartke Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA

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Yimin Fang Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA

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Ana I Sotelo Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Gabriel A Rabinovich Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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María F Troncoso Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Johanna G Miquet Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Kondoh N Hada A Ryo A Shuda M Arai M Matsubara O Kimura F Wakatsuki T Yamamoto M . Activation of galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0292
Volume/Issue:
Volume 8: Issue 8
Open access
Xu Chen Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China

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Yi Tang Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China

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Shen Chen Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Wenhua Ling Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China

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Qing Wang Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China

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. ( https://doi.org/10.1093/nar/gks1193 ) 7 Ahrens M Ammerpohl O von Schonfels W Kolarova J Bens S Itzel T Teufel A Herrmann A Brosch M Hinrichsen H DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0353
Volume/Issue:
Volume 10: Issue 10
Open access
Irasema Mendieta Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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Rosa Elvira Nuñez-Anita Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás Hidalgo, Morelia, Michoacán, Mexico

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Gilberto Pérez-Sánchez Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico

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Lenin Pavón Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico

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Alfredo Rodríguez-Cruz Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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Guadalupe García-Alcocer Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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Laura Cristina Berumen Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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al. in LNCaP cells ( 12 ). In lung cancers, it has been demonstrated that REST1 is highly expressed in NSCLC cells but transcriptionally repressed in SCLC cells. The inactivation of REST1 via methylation is directly related to the expression of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0145
Volume/Issue:
Volume 7: Issue 5
Open access
Dan Liang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Li-Yong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells . Journal of Neuro-Oncology 2011 101 419 – 428 . ( https://doi.org/10.1007/s11060-010-0275-9 ) 7 Al-Mahfoudh R

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-23-0168
Volume/Issue:
Volume 12: Issue 8
Open access
Anela Blažević Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Anand M Iyer Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Marie-Louise F van Velthuysen Department of Pathology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Johannes Hofland Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Peter M van Koestveld Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Gaston J H Franssen Department of Surgery, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Richard A Feelders Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Marina Zajec Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Theo M Luider Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Wouter W de Herder Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Leo J Hofland Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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environmental and epigenetic events ( 18 ). Downregulation of MAO-A by epigenetic methylation and histone acetylation has been demonstrated in cholangiocarcinoma and hepatocellular carcinoma and was associated with increased invasiveness, low tumor

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0020
Volume/Issue:
Volume 11: Issue 4
Open access
Camila Aparecida Moma Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Icléia Siqueira Barreto Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Ligia Vera Montali Assumpção Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Denise Engelbrecht Zantut-Wittmann Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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( 7 ). The main driver mutations appear in the BRAF and RAS genes, leading to deregulation in MAPK pathway signaling, resulting in distinct clinicopathological characteristics and different gene expression and DNA methylation profiles ( 8

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0135
Volume/Issue:
Volume 13: Issue 8
Open access
Souad Daamouch Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Sylvia Thiele Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Lorenz Hofbauer Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Martina Rauner Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Communications 2022 13 807 . ( https://doi.org/10.1038/s41467-022-28266-z ) 45 Reppe S Lien TG Hsu YH Gautvik VT Olstad OK Yu R Bakke HG Lyle R Kringen MK Glad IK , et al . Distinct DNA methylation profiles in bone and blood of

Article Type:
Research Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-23-0251
Volume/Issue:
Volume 12: Issue 11
Open access
Richard W Carroll Endocrine, Diabetes, and Research Centre, Wellington Regional Hospital, New Zealand

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Brian Corley Endocrine, Diabetes, and Research Centre, Wellington Regional Hospital, New Zealand
Department of Medicine, University of Otago, Wellington, New Zealand

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Joe Feltham Department of Radiology, Wellington Regional Hospital, New Zealand

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Patricia Whitfield Endocrine, Diabetes, and Research Centre, Wellington Regional Hospital, New Zealand
Department of Medicine, University of Otago, Wellington, New Zealand

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William Park University of Otago, Wellington, New Zealand

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Rowena Howard Diabetes and Endocrinology Service, Hutt Hospital, New Zealand

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Melissa Yssel Department of Biochemistry & Endocrinology, Awanui Labs, New Zealand

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Ian Phillips Department of Biochemistry, Awanui Labs, Dunedin, New Zealand

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Simon Harper Department of Surgery & Anaesethesia, University of Otago, Wellington, New Zealand
Department of General Surgery, Wellington Regional Hospital, New Zealand

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Jun Yang Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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dopamine-β-monooxygenase action on dopamine ( 27 ). Norepinephrine is converted by methylation to epinephrine, a reaction catalyzed by the enzyme phenylethanolamine N -methyltransferase (PNMT). As this enzyme is expressed primarily in the adrenal medulla

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-23-0300
Volume/Issue:
Volume 13: Issue 2
Open access
André Marques-Pinto Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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Davide Carvalho Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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gametogenesis and foetal development (see below). The epigenome refers to changes made in gene expression by altering DNA structure through DNA methylation and microRNA, among other mechanisms, without changing the actual genomic sequence (80) . BPA, phthalates

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-13-0036
Volume/Issue:
Volume 2: Issue 3
Open access
Jean-Benoît Corcuff Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France

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Laurence Chardon Department of Biochemistry, Edouard Herriot Hospital, Lyon, France

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Ines El Hajji Ridah Biomnis, Lyon, France

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Julie Brossaud Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France

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adrenaline. Dopamine, noradrenaline and adrenaline are inactivated by methylation forming metanephrines that can be sulphated or further metabolised by monoamine oxidases in homovanillic and vanillylmandelic acids (HVA and VMA, respectively

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0071
Volume/Issue:
Volume 6: Issue 6
Open access