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Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch and Elisabeth Lerchbaum

, evidence is accumulating that vitamin D deficiency is also a risk marker for insulin resistance ( 3 ), cardiovascular disease ( 4 ), infectious and autoimmune diseases ( 1 ), cancer ( 5 ), increased mortality ( 2 ) as well as decreased fertility ( 6

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Lars Peter Sørensen, Tina Parkner, Esben Søndergaard, Bo Martin Bibby, Holger Jon Møller and Søren Nielsen

Introduction Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes mellitus (T2DM), but the adverse metabolic consequences of obesity vary between individuals (1) . The mechanisms underlying obesity

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Silan Zheng, Meifeng Tong, Lianqin Dong, Chunmin Du, Xin Zheng, Liying Wang, Peiying Huang, Wei Liu, Mingzhu Lin and Changqin Liu

accurately predict insulin resistance (IR), prediabetes, and type 2 diabetes mellitus (T2DM) ( 15 , 16 , 17 , 18 ). In the present study, we aimed to explore whether the new adiposity indices (LAP, VAI, and TyG) could predict the risk of HS quantified by

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Angela Köninger, Antonella Iannaccone, Ensar Hajder, Mirjam Frank, Boerge Schmidt, Ekkehard Schleussner, Rainer Kimmig, Alexandra Gellhaus and Hans Dieplinger

). PCOS is also associated with several comorbidities resulting in long-term sequelae ( 4 ) like insulin resistance (IR) ( 5 ), obesity ( 6 ) and metabolic syndrome ( 7 ). Although metabolic parameters are not included in the diagnostic criteria, they

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Michaela Keuper

substantiate the strong association between decreased mitochondrial content and oxygen consumption of WAT/adipocytes, which is in particular evident during metabolic complications such as insulin resistance, type 2 diabetes (T2DM) and cardiovascular diseases

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Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos and Manuel H Aguiar-Oliveira

hepatocellular carcinoma is higher than 10% in 5 years (6) . It is therefore important to define the causes of NAFLD. Adult-onset GH deficiency (AOGHD) constitutes a specific model of metabolic syndrome (7, 8) , with visceral obesity, insulin resistance

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Henrik H Thomsen, Holger J Møller, Christian Trolle, Kristian A Groth, Anne Skakkebæk, Anders Bojesen, Christian Høst and Claus H Gravholt

metabolic profile was altogether less favorable with regards to insulin resistance, obesity, diabetes, and hypertension (12) . The level of sCD163 was significantly higher in the KS group by 29% ( Fig. 1 ). There was no significant difference in levels

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Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva and Manuel H Aguiar-Oliveira

metabolic syndrome, with visceral obesity, insulin resistance, endothelial dysfunction, increased sympathetic activity, and a pro-inflammatory profile (3, 4, 5) . Although GH replacement therapy has been shown to reduce the risk profile (6) , it is still

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J Chycki, A Zajac, M Michalczyk, A Maszczyk and J Langfort

different exercise induced adaptations between athletic and obesity phenotypes. These results suggest that individuals with obesity phenotype are more susceptible to insulin resistance, what has been confirmed in obese individuals ( 28 ). Among known

Open access

Thomas Reinehr, Alberto Sánchez-Guijo, Nina Lass and Stefan A Wudy

), while obese men demonstrated decreased testosterone levels ( 4 ). Interestingly, obese women with increased androgens and obese men with low testosterone concentrations are more prone to metabolic disturbances such as insulin resistance, type 2 diabetes