Laura P B Elbers
Laura P B Elbers
Department of Internal Medicine, Medical Center Slotervaart, Amsterdam, the Netherlands
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Marije Wijnberge
Marije Wijnberge
Department of Internal Medicine, Medical Center Slotervaart, Amsterdam, the Netherlands
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, the Netherlands
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Joost C M Meijers
Joost C M Meijers
Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Department of Plasma Proteins, Sanquin Research, Amsterdam, the Netherlands
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Department of Plasma Proteins, Sanquin Research, Amsterdam, the Netherlands
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Dennis C W Poland
Dennis C W Poland
Clinical Chemistry Laboratory, Medical Center Slotervaart, Amsterdam, the Netherlands
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Dees P M Brandjes
Dees P M Brandjes
Department of Internal Medicine, Medical Center Slotervaart, Amsterdam, the Netherlands
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Victor E A Gerdes
Victor E A Gerdes
Department of Internal Medicine, Medical Center Slotervaart, Amsterdam, the Netherlands
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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range; VIDD, vitamin D deficiency; SHPT, secondary hyperparathyroidism; PTH, parathyroid hormone; CRP, C-reactive protein. Coagulation and fibrinolytic parameters Parameters of coagulation, thrombin generation and fibrinolysis are shown in
Sheila Leone
Sheila Leone
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Lucia Recinella
Lucia Recinella
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Annalisa Chiavaroli
Annalisa Chiavaroli
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Claudio Ferrante
Claudio Ferrante
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Giustino Orlando
Giustino Orlando
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Michele Vacca
Michele Vacca
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Roberto Salvatori
Roberto Salvatori
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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Luigi Brunetti
Luigi Brunetti
Department of Pharmacy, G. d’Annunzio University, Chieti, Italy
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Xin He
Xin He
Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Qin Yan
Qin Yan
Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Chazhen Liu
Chazhen Liu
Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Zhengyuan Wang
Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Ping Liao
Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Tong Liu
Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Zehuan Shi
Zehuan Shi
Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Qi Song
Qi Song
Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Xueying Cui
Xueying Cui
Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Wenjing Wang
Wenjing Wang
Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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Jiajie Zang
Jiajie Zang
Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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adulthood ( 2 , 5 , 6 ). Thyroid hormones can regulate metabolism associated with basal metabolic rate and body composition ( 7 , 8 ). In general, the thyroid-stimulating hormone (TSH) is positively correlated with BMI, whereas total thyroxine (TT4) and
Ursula M M Costa
Ursula M M Costa
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Carla R P Oliveira
Carla R P Oliveira
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Roberto Salvatori
Roberto Salvatori
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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José A S Barreto-Filho
José A S Barreto-Filho
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Viviane C Campos
Viviane C Campos
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Francielle T Oliveira
Francielle T Oliveira
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Ivina E S Rocha
Ivina E S Rocha
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Joselina L M Oliveira
Joselina L M Oliveira
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Wersley A Silva
Wersley A Silva
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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Manuel H Aguiar-Oliveira
Manuel H Aguiar-Oliveira
Division of Cardiology, Division of Endocrinology, Division of Endocrinology, Federal University of Sergipe, Aracaju, SE 49060-100, Brazil
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unclear if this is due to GHD per se , or to confounding factors often found in acquired GHD (other pituitary hormone deficiencies, inadequate replacements and pituitary surgery or radiotherapy) (7, 8) . A model of isolated GHD (IGHD) would be preferable
Line Tang Møllehave
Line Tang Møllehave
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
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Marie Holm Eliasen
Marie Holm Eliasen
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
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Ieva Strēle
Ieva Strēle
The Institute of Occupational Safety and Environmental Health, Riga Stradiņš University, Riga, Latvia
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Allan Linneberg
Allan Linneberg
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Rodrigo Moreno-Reyes
Rodrigo Moreno-Reyes
Nuclear Medicine Department, Erasme Hospital, Brussels, Belgium
Université Libre de Bruxelles, Bruxelles, Belgium
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Université Libre de Bruxelles, Bruxelles, Belgium
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Ludmila B Ivanova
Ludmila B Ivanova
Faculty of Medicine, Sofia University St. Kl. Ohridski, Sofia, Bulgaria
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Zvonko Kusić
Zvonko Kusić
Croatian Academy of Sciences and Arts, Zagreb, Croatia
School of Medicine, Zagreb, Croatia
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School of Medicine, Zagreb, Croatia
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Iris Erlund
Iris Erlund
Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland
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Till Ittermann
Till Ittermann
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Endre V Nagy
Endre V Nagy
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Ingibjorg Gunnarsdottir
Ingibjorg Gunnarsdottir
Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland
Department of Clinical Nutrition, Landspitali-National University Hospital, Reykjavik, Iceland
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Department of Clinical Nutrition, Landspitali-National University Hospital, Reykjavik, Iceland
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Jonathan Eli Arbelle
Jonathan Eli Arbelle
Division of Medicine, Maccabi Healthcare Services, Tel Aviv, Israel
Goldman School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel
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Goldman School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel
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Aaron Milton Troen
Aaron Milton Troen
The Institute of Biochemistry Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel
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Valdis Pīrāgs
Valdis Pīrāgs
Internal Medicine, University of Latvia, Riga, Latvia
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Lisbeth Dahl
Lisbeth Dahl
Seafood, Nutrition and Environmental State, Institute of Marine Research (IMR), Bergen, Norway
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Alicja Hubalewska-Dydejczyk
Alicja Hubalewska-Dydejczyk
Chair and Department of Endocrinology, Jagiellonian University, Medical College, Cracow, Poland
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Malgorzata Trofimiuk-Müldner
Malgorzata Trofimiuk-Müldner
Chair and Department of Endocrinology, Jagiellonian University, Medical College, Cracow, Poland
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João Jacome de Castro
João Jacome de Castro
Endocrine Department, Armed Forces Hospital, Lisbon, Portugal
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Mafalda Marcelino
Mafalda Marcelino
Endocrine Department, Armed Forces Hospital, Lisbon, Portugal
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Simona Gaberšček
Simona Gaberšček
Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Katja Zaltel
Katja Zaltel
Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Manuel Puig-Domingo
Manuel Puig-Domingo
Department of Endocrinology and Nutrition, Germans Trias Research Institute and Hospital, Badalona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
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Universitat Autònoma de Barcelona, Barcelona, Spain
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Lluis Vila
Lluis Vila
Endocrinology and Nutrition Service, Hospital Moisés Broggi, Sant Juan Despi, Barcelona, Spain
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Sofia Manousou
Sofia Manousou
Sahlgrenska Academy, Institute of Medicine, Gothenburg, Sweden
Frölunda Specialist Hospital, Västra Frölunda, Sweden
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Frölunda Specialist Hospital, Västra Frölunda, Sweden
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Helena Filipsson Nyström
Helena Filipsson Nyström
Department of Endocrinology, Specialist Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg Centre of Molecular and Translational Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg Centre of Molecular and Translational Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Michael Bruce Zimmermann
Michael Bruce Zimmermann
Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
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Karen R Mullan
Karen R Mullan
Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK
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Jayne Valerie Woodside
Jayne Valerie Woodside
Centre for Public Health, Queen’s University Belfast, Belfast, UK
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Henry Völzke
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Betina Heinsbæk Thuesen
Betina Heinsbæk Thuesen
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
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. Iodine deficiency is associated with adverse outcomes ranging from severe mental retardation and stunting to goiter/thyroid nodules and hyperthyroidism ( 8 ). However, the window of adequate iodine intake is narrow, hence, iodine excess may increase the
Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Biagio Cangiano
Biagio Cangiano
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Marco Bonomi
Marco Bonomi
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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X-linked Mild isolated CeH in males with normal TSH circulating levels, blunted TSH response to TRH Multiple pituitary hormone deficiencies IGSF1 300137 X-linked Mild CeH with normal TSH circulating levels and blunted response
Shota Dzemaili
Shota Dzemaili
University of Lausanne, Institute of Higher Education and Research in Healthcare, Lausanne, Switzerland
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Jitske Tiemensma
Jitske Tiemensma
University of California Merced, Psychological Science, Merced, CA, USA
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Richard Quinton
Richard Quinton
Department of Endocrinology, Institute for Human Genetics, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, United Kingdom
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Nelly Pitteloud
Nelly Pitteloud
Endocrinology, Diabetes & Metabolism Service of the Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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Diane Morin
Diane Morin
University of Lausanne, Institute of Higher Education and Research in Healthcare, Lausanne, Switzerland
Faculty of Nursing Science, Laval University, Québec City, Canada
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Faculty of Nursing Science, Laval University, Québec City, Canada
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Andrew A Dwyer
Andrew A Dwyer
University of Lausanne, Institute of Higher Education and Research in Healthcare, Lausanne, Switzerland
Endocrinology, Diabetes & Metabolism Service of the Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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Endocrinology, Diabetes & Metabolism Service of the Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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Mirjana Doknic
Mirjana Doknic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Marko Stojanovic
Marko Stojanovic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Ivan Soldatovic
Ivan Soldatovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Medical Statistics and Informatics, Belgrade, Serbia
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Institute of Medical Statistics and Informatics, Belgrade, Serbia
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Tatjana Milenkovic
Tatjana Milenkovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Vera Zdravkovic
Vera Zdravkovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
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University Children’s Clinic, Belgrade, Serbia
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Maja Jesic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
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University Children’s Clinic, Belgrade, Serbia
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Sladjana Todorovic
Sladjana Todorovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Katarina Mitrovic
Katarina Mitrovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Rade Vukovic
Rade Vukovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Dragana Miljic
Dragana Miljic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Dragan Savic
Dragan Savic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Mihajlo Milicevic
Mihajlo Milicevic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Aleksandar Stanimirovic
Aleksandar Stanimirovic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Vojislav Bogosavljevic
Vojislav Bogosavljevic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Sandra Pekic
Sandra Pekic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Emilija Manojlovic-Gacic
Emilija Manojlovic-Gacic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Aleksandar Djukic
Aleksandar Djukic
Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
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Danica Grujicic
Danica Grujicic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Milan Petakov
Milan Petakov
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Introduction Patients with childhood-onset GH deficiency (COGHD) represent a heterogeneous group in terms of etiology of growth hormone deficiency (GHD), time of GHD onset and recombinant human GH (rhGH) replacement commencement, duration
H A Booij
H A Booij
Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands
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W D C Gaykema
W D C Gaykema
Roessingh Rehabilitation Center, Enschede, the Netherlands
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K A J Kuijpers
K A J Kuijpers
Roessingh Rehabilitation Center, Enschede, the Netherlands
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M J M Pouwels
M J M Pouwels
Department of Endocrinology, Medisch Spectrum Twente, Enschede, the Netherlands
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H M den Hertog
H M den Hertog
Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands
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injury due to stroke as well. PD and stroke Literature on the prevalence of PD in stroke is scarce, especially for the subacute and chronic phase. The most commonly found endocrine disturbance is growth hormone deficiency (GHD) ( Table 1 ). This
Christine Poitou
Christine Poitou
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris, France
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Anthony Holland
Anthony Holland
Department of Psychiatry, University of Cambridge, UK
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Charlotte Höybye
Charlotte Höybye
Department of Endocrinology and Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
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Laura C G de Graaff
Laura C G de Graaff
Center for Adults with Rare Genetic Syndromes, Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Sandrine Bottius
Sandrine Bottius
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris, France
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Berit Otterlei
Berit Otterlei
Landsforeningen for Prader-Willis Syndrom Hiltonåsen, Slependen, Norway
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Maithé Tauber
Maithé Tauber
Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service d’Endocrinologie, Obésités, Maladies Osseuses, Génétique et Gynécologie Médicale, Hôpital des Enfants, Toulouse, France
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prevented Growth hormone deficiency almost 100% in children and 50% in adults, SGA in 20% Hypogonadism mixed > 60% (adult > 90%) Cryptorchidism more than 90% Premature or agressive adrenarche 30% Hypothyroïdism 20
