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Sanjeet Kumar Jaiswal Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Vijaya Sarathi Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India

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Saba Samad Memon Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Robin Garg Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Gaurav Malhotra Department of Nuclear Medicine, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

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Priyanka Verma Department of Nuclear Medicine, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

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Ravikumar Shah Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Manjeet Kaur Sehemby Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Virendra A Patil Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Swati Jadhav Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Anurag Ranjan Lila Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Nalini S Shah Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Tushar R Bandgar Department of Endocrinology, Seth G.S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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in DDD a well as PFNMN. The major limitations of our study are the small sample size and retrospective nature; thus MIB1-index, chromogranin A, and 68Ga-DOTATATE-PET/CT values were not available at several time points of follow up. Another major

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Qi Zhang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongshan Wang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yanhong Xie Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Suming Huang Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Ke Chen Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Botian Ye Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yupeng Yang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Jie Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongyong He Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Fenglin Liu Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Zhenbin Shen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Weidong Chen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Kuntang Shen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Yihong Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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in gNENs (Prof Ji and Dr Xie) reviewed and confirmed the pathologic characteristics including tumor differentiation, Ki67 index, mitotic count, immunohistochemical results (CD56, chromogranin A (CgA), and synaptophysin (Syn)), and percentage of NEN

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Emmi Naskali Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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Katja Dettmer Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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Peter J Oefner Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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Pedro A B Pereira Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland

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Kai Krohn Clinical Research Institute HUCH Ltd, Biomedicum Helsinki 1, Helsinki, Finland

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Petri Auvinen Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland

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Annamari Ranki Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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Nicolas Kluger Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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chromogranin A and 5-HT ( 9 , 10 , 12 ). We previously observed that severe constipation symptoms were associated with the lack of 5-HT expression in the intestinal tract ( 9 ) and Scarpa and coworkers reported that 5-HT serum levels were significantly lower

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Xu Han Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xuefeng Xu Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongyun Ma Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Dansong Wang Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Tiantao Kuang Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenchuan Wu Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Bin Song Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Gang Li Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Gang Jin Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Wenhui Lou Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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. ( https://doi.org/10.1038/modpathol.2010.166 ) 22 Kim T Tao-Cheng JH Eiden LE Loh YP . Chromogranin A, an ‘on/off’ switch controlling dense-core secretory granule biogenesis. Cell 2001 106 499 – 509 . ( https://doi.org/10.1016/S0092

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E T Aristizabal Prada Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

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C J Auernhammer Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

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and decreases secretion of neuroendocrine markers as neuron-specific enolase, synaptophysin, chromogranin A, represses tryptophan hydroxylase 1 expression and decreases serotonin and 5-hydroxytryptamine secretion ( 166 , 169 ). Ascl1 has been

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