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Introduction Maternal obesity and excessive weight gain during pregnancy is a condition that increases the risk of several complications for both the mother and the growing fetus, with a risk that the fetus will suffer from a suboptimal
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Introduction Central hypothyroidism (CeH) is a rare and heterogenous hypothyroid condition resulting from an insufficient stimulation of an otherwise normal thyroid gland by the hypophyseal thyrotropin hormone (TSH). This loss of central
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of the organism to survival ( 1 ). Some common endocrine diseases including obesity, polycystic ovary syndrome (PCOS), poorly controlled diabetes mellitus (DM), chronic alcoholism, and psychiatric disorders may also coincide with HPA axis activation
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Y Geng Y Zhang Q Huang G Ma Q , et al . DEHP induces obesity and hypothyroidism through both central and peripheral pathways in C3H/He mice . Obesity 2016 368 – 378 . ( https://doi.org/10.1002/oby.21359 ) 16 Schmidt JS Schaedlich
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany
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hypothalamus, where it stimulates appetite-modulating neurons in the arcuate ( 2 ). Clinical studies showed that circulating asprosin levels positively correlated with obesity and type 2 diabetes ( 3 , 4 ). Pre-clinical studies addressing the therapeutic
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France
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Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France
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Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France
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therapeutic targets for the treatment of diabetes and obesity ( 7 , 8 ). 26RFa (also referred to as QRFP) is a hypothalamic neuropeptide discovered concurrently by us and others ( 9 , 10 , 11 ). Subsequently, 26RFa has been characterized in all the
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and decrease energy expenditure, whereas they have the opposite effect in males. This central sexual dimorphic effect of androgens probably contributes to abdominal obesity, insulin resistance and T2DM in hyperandrogenic and hypogonadic conditions in
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Fernandois D Velasco I Rodriguez-Vazquez E Roa J Vazquez MJ Ruiz-Pino F Rubio M Pineda R Central ceramide signaling mediates obesity-induced precocious puberty . Cell Metabolism 2020 32 951 .e8 – 966.e8 . ( https://doi.org/10.1016/j.cmet.2020
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Introduction Central precocious puberty (CPP) is defined as the premature activation of the hypothalamic–pituitary–gonadal axis (HPG) with the onset of breast development before 8 years of age in girls and an increase in testicular size in
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associated oxidative stress are linked to the development of obesity-associated metabolic disturbances, including T2DM ( 5 ), metabolic syndrome ( 6 ), central adiposity and cardiovascular disease ( 7 ). Iron has been shown to be accumulated in the liver and