Nekoo Panahi
Nekoo Panahi
Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Sahar Saeedi Moghaddam
Sahar Saeedi Moghaddam
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Kiel Institute for the World Economy, Kiel, Germany
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Kiel Institute for the World Economy, Kiel, Germany
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Noushin Fahimfar
Noushin Fahimfar
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran
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Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran
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Negar Rezaei
Negar Rezaei
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Mahnaz Sanjari
Mahnaz Sanjari
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Mohammad-Mahdi Rashidi
Mohammad-Mahdi Rashidi
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Parnian Shobeiri
Parnian Shobeiri
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Bagher Larijani
Bagher Larijani
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Afshin Ostovar
Afshin Ostovar
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
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Background Osteoporosis is a degenerative age-related disease characterized by reduced bone mass and deteriorated bone microstructure and predispose individuals to fragility fractures ( 1 ). Bone strength is determined by its quantity and
Rong Xu
Rong Xu
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Difei Lian
Difei Lian
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yan Xie
Yan Xie
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Lin Mu
Lin Mu
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yali Wu
Yali Wu
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Zhilei Chen
Zhilei Chen
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Baoyu Zhang
Baoyu Zhang
Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Introduction Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone mineral density (BMD) and bone mass and destruction of bone microarchitecture, leading to increased bone fragility and increased risk of fracture ( 1
Qianqian Pang
Qianqian Pang
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Musculoskeletal Research Laboratory and Bone Quality and Health Assessment Centre, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, Hong Kong
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Musculoskeletal Research Laboratory and Bone Quality and Health Assessment Centre, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, Hong Kong
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Yuping Xu
Yuping Xu
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Department of Endocrinology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Department of Endocrinology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Xuan Qi
Xuan Qi
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Yan Jiang
Yan Jiang
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Ou Wang
Ou Wang
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Mei Li
Mei Li
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xiaoping Xing
Xiaoping Xing
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Ling Qin
Ling Qin
Musculoskeletal Research Laboratory and Bone Quality and Health Assessment Centre, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, Hong Kong
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Weibo Xia
Weibo Xia
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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manifestations of bones and joints found in patients with homozygous mutations in the HPGD , usually appear earlier than those in the SLCO2A1 , suggesting the clinical heterogeneity between the two subtypes of PHO. It is widely acknowledged that PGE 2 plays
Jennifer Walsh
Jennifer Walsh
The Mellanby Centre for Bone Research, The Medical School, The University of Sheffield, Sheffield, UK
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Neil Gittoes
Neil Gittoes
Centre for Endocrinology, Diabetes and Metabolism, University Hospitals Birmingham & University of Birmingham, Birmingham Health Partners, Birmingham, UK
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Peter Selby
Peter Selby
Department of Medicine, Manchester Royal Infirmary, Manchester, UK
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the Society for Endocrinology Clinical Committee
the Society for Endocrinology Clinical Committee
The Society for Endocrinology, 22 Apex Court, Woodlands, Bradley Stoke, Bristol, UK
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Introduction Under physiological conditions, serum calcium concentration is tightly regulated. Abnormalities of parathyroid function, bone resorption, renal calcium reabsorption or dihydroxylation of vitamin D may cause regulatory mechanisms
Elizaveta Mamedova
Elizaveta Mamedova
Department of Neuroendocrinology and Bone Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Natalya Mokrysheva
Natalya Mokrysheva
Department of Parathyroid Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Evgeny Vasilyev
Evgeny Vasilyev
Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Center, Moscow, Russian Federation
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Vasily Petrov
Vasily Petrov
Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Center, Moscow, Russian Federation
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Ekaterina Pigarova
Ekaterina Pigarova
Department of Neuroendocrinology and Bone Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Sergey Kuznetsov
Sergey Kuznetsov
Department of Surgery, Endocrinology Research Center, Moscow, Russian Federation
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Nikolay Kuznetsov
Nikolay Kuznetsov
Department of Surgery, Endocrinology Research Center, Moscow, Russian Federation
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Liudmila Rozhinskaya
Liudmila Rozhinskaya
Department of Neuroendocrinology and Bone Diseases, Endocrinology Research Center, Moscow, Russian Federation
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Galina Melnichenko
Galina Melnichenko
I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Institute of Clinical Endocrinology, Endocrinology Research Center, Moscow, Russian Federation
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Institute of Clinical Endocrinology, Endocrinology Research Center, Moscow, Russian Federation
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Ivan Dedov
Ivan Dedov
Endocrinology Research Center, Moscow, Russian Federation
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Anatoly Tiulpakov
Anatoly Tiulpakov
Department and Laboratory of Inherited Endocrine Disorders, Endocrinology Research Center, Moscow, Russian Federation
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). The majority of studies on special features of PHPT in young patients demonstrate that in comparison with elderly patients the former have greater morbidity (i.e. symptomatic hypercalcemia, nephrolithiasis, severe bone involvement and nonspecific
Janko Sattler
Janko Sattler
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Jinwen Tu
Jinwen Tu
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Shihani Stoner
Shihani Stoner
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
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Jingbao Li
Jingbao Li
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Frank Buttgereit
Frank Buttgereit
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Markus J Seibel
Markus J Seibel
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Hong Zhou
Hong Zhou
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
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Mark S Cooper
Mark S Cooper
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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patients . New England Journal of Medicine 2003 348 727 – 734 . ( https://doi.org/10.1056/NEJMra020529 ) 2 Raza K Hardy R Cooper MS . The 11beta-hydroxysteroid dehydrogenase enzymes – arbiters of the effects of glucocorticoids in synovium and bone
Nancy Martini
Nancy Martini
Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral (LIOMM-UNLP-CICPBA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
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Lucas Streckwall
Lucas Streckwall
Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral (LIOMM-UNLP-CICPBA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
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Antonio Desmond McCarthy
Antonio Desmond McCarthy
Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral (LIOMM-UNLP-CICPBA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
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post-menopausal women and/or aged individuals, particularly if they present with conditions such as diabetes mellitus, chronic renal disease or metabolic syndrome, the arterial wall can acquire a considerable load of calcifications, while bone mineral
Sylvia Thiele
Sylvia Thiele
Department of Medicine III, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Anke Hannemann
Anke Hannemann
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
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Maria Winzer
Maria Winzer
Department of Medicine III, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Ulrike Baschant
Ulrike Baschant
Department of Medicine III, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Heike Weidner
Heike Weidner
Department of Medicine III, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Matthias Nauck
Matthias Nauck
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
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Rajesh V Thakker
Rajesh V Thakker
Academic Endocrine Unit, Radcliffe Department of Medicine University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford, UK
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Martin Bornhäuser
Martin Bornhäuser
Department of Medicine I, Technische Universität Dresden, Dresden, Germany
DFG Research Center and Cluster of Excellence for Regenerative Therapies, Technical University, Dresden, Germany
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DFG Research Center and Cluster of Excellence for Regenerative Therapies, Technical University, Dresden, Germany
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Lorenz C Hofbauer
Lorenz C Hofbauer
Department of Medicine III, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
DFG Research Center and Cluster of Excellence for Regenerative Therapies, Technical University, Dresden, Germany
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Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
DFG Research Center and Cluster of Excellence for Regenerative Therapies, Technical University, Dresden, Germany
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Martina Rauner
Martina Rauner
Department of Medicine III, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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bone mass and strength, resulting in increased osteoporotic fracture probability ( 1 ). Chronic GC therapy leads to decreased bone mineral density, and up to 50% of treated patients experience vertebral fractures ( 2 ). The complex pathogenesis of
Alexander A L Jorge
Alexander A L Jorge
Unidade de Endocrinologia-Genetica, LIM/25, Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Sao Paulo, Brazil
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Thomas Edouard
Thomas Edouard
Endocrine, Bone Diseases, and Genetics Unit, Children’s Hospital, Toulouse University Hospital, RESTORE INSERM UMR1301, Toulouse, France
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Mohamad Maghnie
Mohamad Maghnie
Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Alberto Pietropoli
Alberto Pietropoli
Novo Nordisk Health Care AG, Global Medical Affairs Biopharm, Zürich, Switzerland
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Nicky Kelepouris
Nicky Kelepouris
Novo Nordisk Inc., Clinical, Medical and Regulatory Biopharm-RED, Plainsboro, New Jersey, USA
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Alicia Romano
Alicia Romano
Department of Pediatrics, New York Medical College, Valhalla, New York, USA
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Martin Zenker
Martin Zenker
Institute of Human Genetics & Department of Pediatrics, University Hospital, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
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Reiko Horikawa
Reiko Horikawa
Department of Endocrine and Metabolism, National Center for Child Health and Development, Tokyo, Japan
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addition, puberty is often delayed and is accompanied by a delay in bone age ( 1 , 9 , 11 ). It is estimated that over 50% of females and almost 40% of males with NS have an adult height below the third percentile ( 1 ). Abnormalities of growth hormone
Eva Novoa
Eva Novoa
Department of Otorhinolaryngology, Clinic of Endocrinology, Head and Neck Surgery
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Marcel Gärtner
Marcel Gärtner
Department of Otorhinolaryngology, Clinic of Endocrinology, Head and Neck Surgery
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Christoph Henzen
Christoph Henzen
Department of Otorhinolaryngology, Clinic of Endocrinology, Head and Neck Surgery
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aimed to assess the possible systemic effects of IT-Dex injections on the HPA axis and bone metabolism, particularly on osteoblast function, as highly sensitive cells to exogenous glucocorticoids, in a prospective cohort study of patients receiving IT
