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Roxanne C S van Adrichem Department of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, Rotterdam, The Netherlands

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Aart Jan van der Lely Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Martin Huisman Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Piet Kramer Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Richard A Feelders Department of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, Rotterdam, The Netherlands

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Patric J D Delhanty Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, Rotterdam, The Netherlands

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following: past or existent malignancies; endocrine disorders including diabetes mellitus, acromegaly, Cushing syndrome; metabolic syndrome; any active use of glucocorticoids; active inflammatory or infectious disease; past gastric surgery, kidney, or liver

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Elena Pardi Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Stefano Mariotti Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Natalia S Pellegata Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Katiuscia Benfini Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Simona Borsari Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Federica Saponaro Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Liborio Torregrossa Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Antonello Cappai Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Chiara Satta Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Marco Mastinu Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Claudio Marcocci Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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Filomena Cetani Endocrine Unit 2, Endocrinology Unit, Institute of Pathology, Department of Surgical, Department of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Pisa, Italy

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transfected with sequence encoding the W76X nonsense variant found in the first MEN4 patient, affected by PHPT and acromegaly (7) . Notably, both the S125X and the W76X mutations have previously been detected in a somatic setting in a small intestine NET (SI

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Marcus Quinkler Endocrinology in Charlottenburg, Berlin, Germany

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Bertil Ekman Departments of Endocrinology and Medical and Health Sciences, Linköping University, Linköping, Sweden

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Claudio Marelli Shire International GmbH, Zug, Switzerland

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Sharif Uddin Shire, Lexington, Massachusetts, USA

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Pierre Zelissen Department of Internal Medicine and Endocrinology, University Medical Center Utrecht, Utrecht, the Netherlands

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Robert D Murray Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James’s University Hospital, Leeds, UK

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on behalf of the EU-AIR Investigators
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Sheppard MC Hawkins MM Bates AS Stewart PM. ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly . Journal of Clinical Endocrinology and Metabolism

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Giovanni Tulipano Unit of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

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directions . CNS Oncology 2015 411 – 429 . ( https://doi.org/10.2217/cns.15.21 ) 94 Giustina A Mazziotti G Torri V Spinello M Floriani I Melmed S. Metanalysis on the effects of octreotide on tumor mass in acromegaly . PLoS ONE 2012 e

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Ida Staby Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Jesper Krogh Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Marianne Klose Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Jonas Baekdal Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark

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Lars Poulsgaard Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Jacob Bertram Springborg Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Mikkel Andreassen Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark

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/oligomenorrhoea for premenopausal women. A diagnosis of Cushing’s disease or acromegaly was established according to the standard criteria. We did not report on GH deficiency or anti-diuretic hormone insufficiency because only a few patients were examined with GH

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Charlotte Höybye Patient Area Endocrinology and Nephrology, Infection and Inflammation Theme, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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Laia Faseh Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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Christos Himonakos Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Department of Medicine, Karlstad Hospital, Karlstad, Sweden

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Tomasz Pielak NUTOPI Sp. z o. o., Poznan, Poland

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Jesper Eugen-Olsen Clinical Research Centre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

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interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency . Clinical Endocrinology 2007 67 909 – 916 . ( https://doi.org/10.1111/j.1365-2265.2007.02986.x ) 17727678 10.1111/j.1365-2265.2007.02986.x 29 Leonsson

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Eva Jakobsson Ung Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ann-Charlotte Olofsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ida Björkman Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden

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Tobias Hallén Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden

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Daniel S Olsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Oskar Ragnarsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Thomas Skoglund Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden

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Sofie Jakobsson Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden

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Gudmundur Johannsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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a 2  Other lesions in the pituitary b 4  Invasiveness (para sellar) 10 Surgical treatment  Primary surgery, TS/TC 16/0  Re-surgery, TS/TC 2/1 a One patient with acromegaly and one with Cushing

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María L Bacigalupo Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Verónica G Piazza Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Nadia S Cicconi Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Pablo Carabias Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Andrzej Bartke Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA

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Yimin Fang Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA

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Ana I Sotelo Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Gabriel A Rabinovich Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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María F Troncoso Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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Johanna G Miquet Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

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R Grottoli S Losa M Cannavo S , et al . Acromegaly is associated with increased cancer risk: a survey in Italy . Endocrine-Related Cancer 2017 24 . ( https://doi.org/10.1530/ERC-16-0553 ) 10 Bugni JM Poole TM Drinkwater NR

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Ali Abbara Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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Sophie Clarke Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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Pei Chia Eng Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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James Milburn Imperial College Healthcare NHS Trust, London, UK

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Devavrata Joshi Imperial College Healthcare NHS Trust, London, UK

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Alexander N Comninos Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK
Imperial College Healthcare NHS Trust, London, UK

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Rozana Ramli Imperial College Healthcare NHS Trust, London, UK

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Amrish Mehta Imperial College Healthcare NHS Trust, London, UK

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Brynmor Jones Imperial College Healthcare NHS Trust, London, UK

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Florian Wernig Imperial College Healthcare NHS Trust, London, UK

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Ramesh Nair Imperial College Healthcare NHS Trust, London, UK

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Nigel Mendoza Imperial College Healthcare NHS Trust, London, UK

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Amir H Sam Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK
Imperial College Healthcare NHS Trust, London, UK

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Emma Hatfield Imperial College Healthcare NHS Trust, London, UK

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Karim Meeran Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK
Imperial College Healthcare NHS Trust, London, UK

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Waljit S Dhillo Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK
Imperial College Healthcare NHS Trust, London, UK

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Niamh M Martin Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK
Imperial College Healthcare NHS Trust, London, UK

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acromegaly patient with pituitary macroadenoma . Endocrinology, Diabetes and Metabolism Case Reports 2017 17-0044. ( https://doi.org/10.1530/EDM-17-0044 ) 30 Verbalis JG Goldsmith SR Greenberg A Korzelius C Schrier RW Sterns RH Thompson CJ. Diagnosis

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Mark R Postma Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Pia Burman Department of Endocrinology, Skane University Hospital Malmö, University of Lund, Lund, Sweden

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André P van Beek Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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patients with a previous diagnosis of Cushing’s disease, acromegaly and craniopharyngioma because these conditions are known to affect body composition, cardiovascular risk factors and quality of life. For similar reasons of confounding bias, females

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