Department of Epidemiology St. Luke’s International University Graduate School of Public Health, Tokyo, Japan
Fujita Health University Toyoake, Japan
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Department of Epidemiology St. Luke’s International University Graduate School of Public Health, Tokyo, Japan
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Introduction Previous systematic reviews and meta-analyses have reported that diabetic patients have a higher risk of developing malignancies compared to nondiabetic patients ( 1 , 2 , 3 , 4 ). Based on these reports, diabetic patients may
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Introduction Pancreatic neuroendocrine tumors (PNETs), also known as islet cell tumors, are rare neoplasms arising from the endocrine pancreas, with a reported incidence of <1 per 100,000 persons per year ( 1 , 2 ). However, the incidence of
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Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester, UK
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Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester, UK
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Introduction Type 1 diabetes (T1D) affects 25,000 children and young adults in the United Kingdom ( 1 ). Intensive glycaemic control is crucial to avoid long-term complications ( 2 ) but only 18.4% are meeting the National Institute for Health
Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Biomedicine, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Introduction Patients with metabolic syndrome are at significant risk for developing type 2 diabetes mellitus and cardiovascular diseases ( 1 ). Arginine vasopressin (AVP) was suggested to play a causal role in the development of type 2
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumours. In addition, some patients may also develop adrenal
European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany
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therapies under investigation Atezolizumab Bevacizumab Cobimetinib Vemurafenib Paclitaxel Nab-Paclitaxel NCT03181100 Atezolizumab: PD-1L Bevacizumab: VEGFR Cobimetinib: MEK1, MEK2 Vemurafenib: BRAF V600E Paclitaxel: antimicrotubule agent Nab
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–Pyle (GP) ( 1 ) and calculation of predicted height by the method of Bayley–Pinneau (BP) ( 2 ) or the Tanner Whitehouse 2 (TW2) method ( 3 ). While bone age predicts with acceptable accuracy the adult height in healthy children ( 4 , 5 , 6 ), in
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2011 365 2389 – 2397 . ( doi:10.1056/NEJMcp1106636 ). 2 Turner JJ Christie PT Pearce SH Turnpenny PD Thakker RV . Diagnostic challenges due to phenocopies: lessons from multiple endocrine neoplasia type1 (MEN1) . Human Mutation 2010
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Introduction Diabetic nephropathy is a major microvascular complication of type 2 diabetes mellitus (DM), and in many countries of the world, it is the major cause of end-stage renal disease (ESRD) ( 1 , 2 , 3 ). Identification of high
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Department of Clinical and Toxicological Analyses, Natal, Rio Grande do Norte, Brazil
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Department of Nutrition, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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.98) Probably damaging (0.0768) 12.35 Deleterious (0.807) TRANK1 chr3:36887865 T>C p.T1645A - Nonsynonymous SNV Deleterious (0) Probably damaging (0.995) - 25.0 Deleterious (0.902) POMGNT2 chr3:43121810 C>T p.D372N rs