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Julie M Silverstein

, as was demonstrated by the results of a meta-analysis study in acromegaly (16) . However, with the advent of more sensitive assays to detect GH and IGF1 levels, more stringent definitions of biochemical control in patients with acromegaly have been

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Julia Kubiak, Per Medbøe Thorsby, Elena Kamycheva and Rolf Jorde

processes ( 1 ). Low serum 25(OH)D levels have additionally been related to numerous diseases, including cardiovascular disease (CVD) and their risk factors ( 2 ). Thus, a meta-analysis of 19 prospective studies focusing on the relation between vitamin D

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Dorte Glintborg, Katrine Hass Rubin, Mads Nybo, Bo Abrahamsen and Marianne Andersen

antibodies ( 8 ). A recent meta-analysis reported an odds ratio (OR) of 3.3 (95% CI 2.3–4.6) for autoimmune thyroid disease in women with PCOS ( 9 ). The risk of overt hypothyroidism in PCOS is less described than the risk of autoimmune thyroiditis. In a

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Ann-Kristin Picke, Graeme Campbell, Nicola Napoli, Lorenz C Hofbauer and Martina Rauner

type I C-terminal telopeptide (CTX) are reported to have either increased or decreased in T2DM cohorts (reviewed in 60 ). A meta-analysis of 66 studies however revealed an overall low bone turnover with low levels of CTX in diabetic patients ( 13 ). In

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Charlotte Janus, Dorte Vistisen, Hanan Amadid, Daniel R Witte, Torsten Lauritzen, Søren Brage, Anne-Louise Bjerregaard, Torben Hansen, Jens J Holst, Marit E Jørgensen, Oluf Pedersen, Kristine Færch and Signe S Torekov

sedentary lifestyle, which constitutes an independent health risk ( 2 ). In high-income countries, the second most important preventable cause of premature death is physical inactivity, next to smoking ( 2 , 3 ). A recent meta-analysis of data from studies

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Dorte Glintborg, Magda Lambaa Altinok, Pernille Ravn, Kurt Bjerregaard Stage, Kurt Højlund and Marianne Andersen

(<2500 g) ( 13 ). Included men were insulin resistant and had high cortisol levels ( 13 ). In women, low birth weight increased the risk of elevated adrenal activity and development of PCOS ( 14 ). A meta-analysis found improved glycemic control in

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Mubashir Mulla and Klaus-Martin Schulte

’ values. A recent meta-analysis by Wu et al . (40) looked at the accuracy of US in the detection of metastatic LN. They provide ‘pooled sensitivity’ figures of 0.72 and 0.63 for patient- and region-based LND respectively. This pooled sensitivity is

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Hyun-Ah Kim, Jihye Choi, Chan Sub Park, Min-Ki Seong, Sung-Eun Hong, Jae-Sung Kim, In-Chul Park, Jin Kyung Lee, Woo Chul Noh and the ASTRRA trial investigators

age at prediction of menstruation resumption was validated in univariate analysis only ( P  = 0.009). This might be explained by the requirement for all patients enrolled at ASTRRA to be ≤45 years. According to a recent meta-analysis, younger age (<40

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M A Webb, H Mani, S J Robertson, H L Waller, D R Webb, C L Edwardson, D H Bodicoat, T Yates, K Khunti and M J Davies

that PA reduces expression of CD14+ and CD16 positive monocytes cells which are potent producers of inflammatory cytokines ( 29 ). Whilst a plethora of reports have shown an increased risk of CVD and T2DM with PCOS, meta-analysis has not detected an

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Peter D Mark, Mikkel Andreassen, Claus L Petersen, Andreas Kjaer and Jens Faber

Metabolism, Herlev University Hospital, 54O4, are thanked for their great help in collecting data. References 1 Faber J Galløe AM . Changes in bone mass during prolonged subclinical hyperthyroidism due to l -thyroxine treatment: a meta-analysis