Yao Ye
Yao Ye
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Aurelia Vattai
Aurelia Vattai
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Nina Ditsch
Nina Ditsch
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Christina Kuhn
Christina Kuhn
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Martina Rahmeh
Martina Rahmeh
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Sven Mahner
Sven Mahner
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Myriam Ripphahn
Myriam Ripphahn
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Roland Immler
Roland Immler
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Markus Sperandio
Markus Sperandio
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Udo Jeschke
Udo Jeschke
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Viktoria von Schönfeldt
Viktoria von Schönfeldt
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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1% of all women worldwide ( 2 ), and only a minority can be explained by particular causative factors, including genetic abnormalities, structural abnormalities, infection, endocrine abnormalities, immune dysfunction and thrombophilic disorders ( 1
Bharat Kumar
Bharat Kumar
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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Madhukar Mittal
Madhukar Mittal
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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Maya Gopalakrishnan
Maya Gopalakrishnan
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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Mahendra K Garg
Mahendra K Garg
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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Sanjeev Misra
Sanjeev Misra
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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milieu, causing intracellular and extracellular dehydration, inducing electrolyte abnormalities, and depressing immune function ( 13 , 14 , 15 , 16 ). There are reports of association of plasma glucose at admission with morbidity and mortality with
Weiwei Liang
Weiwei Liang
W Liang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Junxin Chen
Junxin Chen
J Chen, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guang Zhou, China
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Hai Li
Hai Li
H Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Pengyuan Zhang
Pengyuan Zhang
P Zhang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Hongyu Guan
Hongyu Guan
H Guan, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Yanbing Li
Yanbing Li
Y Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guanzhou, China
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Background: Collagen type VIII α 1 chain (COL8A1), a collagen type VIII protein, has been suggested to exert various functions in progression of multiple cancers. However, the effect of COL8A1 in papillary thyroid cancer (PTC) has not been elucidated.
Methods: The Cancer Genome Atlas (TCGA) databases were applied to investigate the COL8A1 expression and its clinical significance in PTC. The COL8A1 expression level was further validated using Gene Expression Omnibus (GEO) data and clinical paired PTC tissues. Additionally, Kaplan-Meier curve was used to analyze the prognosis. The cell migrative and invasive abilities were evaluated by wound healing assay and Transwell assay. CCK8 assays were used to evaluate proliferation of PTC cells. Western blotting was conducted to explore the potential mechanisms involved in the pro-tumor role of COL8A1. The correlation between immune cell infiltration and COL8A1 was analyzed using Tumor Immune Estimation Resource (TIMER) database and the single-sample GSEA (ssGSEA) method.
Results: We found that COL8A1 was upregulated in PTC (P<0.05). High COL8A1 expression level was significantly associated with advanced T stage (P<0.01), N stage (P<0.001) and poor prognosis (P=0.0142) in PTC. Furthermore, cell migration and invasion were significantly reduced following COL8A1 knockdown (P<0.001). Mechanistic studies demonstrated that the epithelial-to-mesenchymal transition (EMT) related proteins (FN1, MMP9, MMP7, ZEB2 and Twist1) and phosphorylation of AKT and ERK were obviously down-regulated after COL8A1 knockdown (P<0.01). Moreover, COL8A1 expression was correlated with immune cell infiltration.
Conclusion: Our study demonstrates that COL8A1 may function as an oncogene and a potential prognostic biomarker for PTC patients.
Deborah Cosentini
Deborah Cosentini
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Salvatore Grisanti
Salvatore Grisanti
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Alberto Dalla Volta
Alberto Dalla Volta
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Marta Laganà
Marta Laganà
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Chiara Fiorentini
Chiara Fiorentini
Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
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Paola Perotti
Paola Perotti
Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Italy
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Sandra Sigala
Sandra Sigala
Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
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Alfredo Berruti
Alfredo Berruti
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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effective second-line therapies are available for patients with disease progression to EDP and mitotane ( 3 ). The concept that immune system modulation can lead to a long-lasting control of tumor growth is well known since decades. However, the interest
Natacha Driessens
Natacha Driessens
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Madhu Prasai
Madhu Prasai
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Orsalia Alexopoulou
Orsalia Alexopoulou
Department of Endocrinology, Cliniques Universitaires Saint Luc, Brussels, Belgium
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Christophe De Block
Christophe De Block
Department of Endocrinology-Diabetology-Metabolism, Universitair Ziekenhuis Antwerpen & University of Antwerp, Drie Eikenstraat, Edegem, Belgium
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Eva Van Caenegem
Eva Van Caenegem
Department of Endocrinology, Academisch Ziekenhuis Sint-Jan Brugge – Oostende AV, Ruddershove, Brugge, Belgium
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Guy T’Sjoen
Guy T’Sjoen
Department of Endocrinology, Ghent Universitary Hospital, C. Heymanslaan, Gent, Belgium
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Frank Nobels
Frank Nobels
Department of Endocrinology, Onze-Lieve Vrouw Ziekenhuis, Moorselbaan, Aalst, Belgium
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Christophe Ghys
Christophe Ghys
Department of Endocrinology, Universitair Ziekenhuis Brussel, Laarbeeklaan, Brussels, Belgium
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Laurent Vroonen
Laurent Vroonen
Department of Endocrinology, Cliniques Universitaires de Liège, Avenue de l’hôpital, Liège, Belgium
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Corinne Jonas
Corinne Jonas
Department of Endocrinology, CHU UCL Namur - Godinne, Avenue Docteur Gaston Thérasse, Yvoir, Belgium
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Bernard Corvilain
Bernard Corvilain
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Dominique Maiter
Dominique Maiter
Department of Endocrinology, Cliniques Universitaires Saint Luc, Brussels, Belgium
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Introduction Primary adrenal insufficiency (PAI) is a rare disease, most commonly of auto-immune origin. There is a global variation in prevalence from 80 to 145 per million in Europe, with the highest case numbers reported in Scandinavian
Xiaoya Zheng
Xiaoya Zheng
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Heng Xiao
Heng Xiao
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jian Long
Jian Long
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qiang Wei
Qiang Wei
Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China
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Liping Liu
Liping Liu
Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Liping Zan
Liping Zan
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Wei Ren
Wei Ren
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Introduction Programmed cell death protein-1 (PD-1) blockade therapies are widely used for the treatment of hepatocellular carcinoma (HCC) ( 1 ). In addition to their antitumor effects, anti-PD-1 antibodies have been reported to cause immune
Aaron Lerner
Aaron Lerner
B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
AESKU.KIPP Institute, Wendelsheim, Germany
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AESKU.KIPP Institute, Wendelsheim, Germany
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Patricia Jeremias
Patricia Jeremias
AESKU.KIPP Institute, Wendelsheim, Germany
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Torsten Matthias
Torsten Matthias
AESKU.KIPP Institute, Wendelsheim, Germany
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. Recent studies have shown that it may be beneficial to screen ATD for CD as well ( 8 , 9 ). Intestinal pathology in thyroid diseases Only a single layer of epithelial cells separates the luminal contents from effector immune cells in the lamina
Stavroula A Paschou
Stavroula A Paschou
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Nektaria Papadopoulou-Marketou
Nektaria Papadopoulou-Marketou
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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George P Chrousos
George P Chrousos
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Christina Kanaka-Gantenbein
Christina Kanaka-Gantenbein
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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1. Viruses (rubella, enteroviruses) 2. Diet (cow’s milk, cereals, omega-3 fatty acids, vitamin D) 3. Gut microbiota D. Immunologic factors 1. Immune tolerance (central, peripheral, Tregs) 2. Cellular immunity
Stefano Mangiola
Stefano Mangiola
Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Ryan Stuchbery
Ryan Stuchbery
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
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Patrick McCoy
Patrick McCoy
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Ken Chow
Ken Chow
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Natalie Kurganovs
Natalie Kurganovs
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Ontario Institute for Cancer Research, Toronto, Canada
Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
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Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Ontario Institute for Cancer Research, Toronto, Canada
Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
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Michael Kerger
Michael Kerger
Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
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Anthony Papenfuss
Anthony Papenfuss
Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia
Department of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia
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Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia
Department of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia
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Christopher M Hovens
Christopher M Hovens
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Niall M Corcoran
Niall M Corcoran
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia
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Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia
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potential to influence prostate hormonal and immune homeostasis ( 22 ). Here for the first time, based on a unique cohort of patients with 6-month profound androgen suppression and receptor blockade, we performed an integrative study of the molecular and
Zhengrong Jiang
Zhengrong Jiang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Linghong Huang
Linghong Huang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Lijun Chen
Lijun Chen
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Jingxiong Zhou
Jingxiong Zhou
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Bo Liang
Bo Liang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Xuefeng Bai
Xuefeng Bai
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Lizhen Wu
Lizhen Wu
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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Huibin Huang
Huibin Huang
Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
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insight into the relationship between circRNAs and GD is still required. Cytokines are a group of small molecules secreted by a variety of tissue cells (mainly immune cells), which play a central role in initiating immune cascades through their receptors
