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(prolactinoma, 9; acromegaly, 1; non-functioning tumor, 8) being 1 case operated 2 months after PTx by non-functioning while other waited surgery for acromegaly performed more 1 year after PTx. A pancreatectomy by pancreatic NET had been performed previously in
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Sheppard MC Hawkins MM Bates AS Stewart PM. ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly . Journal of Clinical Endocrinology and Metabolism
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, elevated androgen levels, alopecia, acromegaly, hypothyroidism, hyperthyroidism, liver cirrhosis, and use of oral contraceptive or anti-epileptic drugs were excluded. Measurements The following data were recorded at baseline: smoking, alcohol
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following: past or existent malignancies; endocrine disorders including diabetes mellitus, acromegaly, Cushing syndrome; metabolic syndrome; any active use of glucocorticoids; active inflammatory or infectious disease; past gastric surgery, kidney, or liver
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transfected with sequence encoding the W76X nonsense variant found in the first MEN4 patient, affected by PHPT and acromegaly (7) . Notably, both the S125X and the W76X mutations have previously been detected in a somatic setting in a small intestine NET (SI
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